Publication: Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza
Issued Date
2006-03-01
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-33646006363
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.69, No.3 (2006), 421-424
Suggested Citation
Sudarat Homhual, Nuntavan Bunyapraphatsara, Tamara Kondratyuk, Angkana Herunsalee, Wongsatit Chaukul, John M. Pezzuto, Harry H S Fong, Hong Jie Zhang Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza. Journal of Natural Products. Vol.69, No.3 (2006), 421-424. doi:10.1021/np058112x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22913
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Title
Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza
Abstract
Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC50 values of 7.8, 9.4, and 15.7 μM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFκB (nuclear factor-κB) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays. © 2006 American Chemical Society and American Society of Pharmacognosy.