Publication: Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza
| dc.contributor.author | Sudarat Homhual | en_US |
| dc.contributor.author | Nuntavan Bunyapraphatsara | en_US |
| dc.contributor.author | Tamara Kondratyuk | en_US |
| dc.contributor.author | Angkana Herunsalee | en_US |
| dc.contributor.author | Wongsatit Chaukul | en_US |
| dc.contributor.author | John M. Pezzuto | en_US |
| dc.contributor.author | Harry H S Fong | en_US |
| dc.contributor.author | Hong Jie Zhang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Purdue University | en_US |
| dc.contributor.other | Thailand Ministry of Public Health | en_US |
| dc.contributor.other | University of Illinois at Chicago | en_US |
| dc.date.accessioned | 2018-08-20T06:48:29Z | |
| dc.date.available | 2018-08-20T06:48:29Z | |
| dc.date.issued | 2006-03-01 | en_US |
| dc.description.abstract | Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC50 values of 7.8, 9.4, and 15.7 μM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFκB (nuclear factor-κB) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays. © 2006 American Chemical Society and American Society of Pharmacognosy. | en_US |
| dc.identifier.citation | Journal of Natural Products. Vol.69, No.3 (2006), 421-424 | en_US |
| dc.identifier.doi | 10.1021/np058112x | en_US |
| dc.identifier.issn | 01633864 | en_US |
| dc.identifier.other | 2-s2.0-33646006363 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/22913 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33646006363&origin=inward | en_US |
| dc.subject | Agricultural and Biological Sciences | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33646006363&origin=inward | en_US |