Browsing by Author "Witoon Youngsa-ad"

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    Diterpenoids from the roots of Croton oblongifolius
    (2007-11-01) Witoon Youngsa-ad; Nattaya Ngamrojanavanich; Chulabhorn Mahidol; Somsak Ruchirawat; Hunsa Prawat; Prasat Kittakoop; Chulabhorn Research Institute; Chulalongkorn University; Chulabhorn Graduate Institute; The Institute of Science and Technology for Research and Development, Mahidol University
    Two new clerodane diterpenes, methyl 15,16-epoxy-3,13(16),14-ent- clerodatrien-18,19-olide-17-carboxylate (1) and dimethyl 15,16-epoxy-12-oxo-3, 13(16),14-ent-clerodatriene-17,18-dicarboxylate (2), together with seven known compounds (3-9), were isolated from the roots of Croton oblongifolius. The isolated compounds showed only mild cytotoxic activity against HuCCA-1, KB, HeLa, MDA-MB231, and T47D cell lines with IC50 values ranging from 10 to 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.