Browsing by Type "Note"

Filter results by typing the first few letters
Now showing 1 - 20 of 315
  • No Thumbnail Available
    PublicationMetadata only
    (2786) Proposal to change the conserved type of Ipomoea, nom. cons. (Convolvulaceae)
    (2020-12-01) Lauren A. Eserman; Marc S.M. Sosef; Rosângela Simão-Bianchini; Timothy M.A. Utteridge; Juliana C.J. Barbosa; Maria Teresa Buril; Lars W. Chatrou; Keith Clay; Geadelande Delgado; Thibaut E. Desquilbet; Priscila P.A. Ferreira; José R. Grande Allende; Alexis L. Hernández; Guillermo Huerta-Ramos; Robert L. Jarret; Roberta K. Kojima; Sven Landrein; Juliana A.A.M. Lourenço; Ine De Man; Richard E. Miller; Sushant More; André L.C. Moreira; Ithe Mwanga-Mwanga; Stella Nhanala; Mayara Pastore; Fernanda S. Petrongari; Ponprom Pisuttimarn; Pimwadee Pornpongrungrueng; Joanna Rifkin; Francisco D.S. Santos; Vinod B. Shimpale; Simone S. Silva; John R. Stinchcombe; Paweena Traiperm; Liziane V. Vasconcelos; Ming Li Wang; Arthur Villordon; Jun Yang; G. Craig Yencho; Bettina Heider; Ana Rita G. Simões; UNAM Campus Morelia; The New College, Kolhapur; Centro Internacional de la Papa, Peru; Universiteit Gent; Universidade de Brasília; Chinese Academy of Sciences; Tulane University; Khon Kaen University; Botanic Garden Meise; University of Toronto; Universidade Federal da Bahia; Mahidol University; Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences; Museu Paraense Emilio Goeldi; NC State University; Universidad De Los Andes, Merida; USDA Agricultural Research Service, Washington DC; Universidade Federal do Para; Instituto de Botânica de Sao Paulo; Universidade Federal Rural de Pernambuco; Royal Botanic Gardens, Kew; Secretaria do Meio Ambiente e Infraestrutura do Rio Grande do Sul; Lycée Descartes; Manuel Negrete Pte. #9; Parle Tilak Vidyalaya Association's Sathaye College; Centre de Recherche en Sciences Naturelles CRSN/Lwiro DS/Bukavu; Louisiana State University Agricultural Center; Flower Diversity Institute; Instituto de Investigação Agrária de Moçambique (IIAM); Atlanta Botanical Garden
  • No Thumbnail Available
    PublicationMetadata only
    A 29-year-old man with progressive short term memory loss
    (2014-01-01) Jantima Tanboon; Thaweesak Aurboonyawat; Orasa Chawalparit; Mahidol University
  • No Thumbnail Available
    PublicationMetadata only
    A 76 -year-old man with anemia, bone pain, and progressive dyspnea
    (2014-01-01) Thitiporn Suwatanapongched; Prapaporn Pornsuriyasak; Wasana Kanoksil; Thotsaporn Morasert; Warapat Virayavanich; Mahidol University
  • No Thumbnail Available
    ItemMetadata only
    A Case of Extensive Mass on the Scalp with Alopecia
    (2022-01-01) Pomsoong C.; Mahidol University
  • No Thumbnail Available
    ItemMetadata only
    A Concise Synthesis towards Antimalarial Quinazolinedione TCMDC-125133 and Its Anti-Proliferative Activity against MCF-7
    (2022-06-01) Charoensutthivarakul S.; Lohawittayanan D.; Kanjanasirirat P.; Jearawuttanakul K.; Seemakhan S.; Borwornpinyo S.; Phanchana M.; Mahidol University
    Quinazolinedione is one of the most notable pharmacophores in drug discovery due to its broad spectrum of biological activities including antimalarial, anticancer, anti-inflammatory, and others. TCMDC-125133, whose structure features a quinazolinedione core, exhibits promising antimalarial activity and low toxicity as described in the GlaxoSmithKline (GSK) report. Herein, a concise four-step synthesis towards quinazolinedione TCMDC-125133 is described using low cost goods and greener alternatives where possible. All synthesized compounds were characterized using polarimetry, IR, NMR, and mass spectrometry. The in-house synthesized TCMDC-125133 was evaluated for its antimalarial activity against P. falciparum 3D7 and antiproliferative activity against MCF-7 cell line.
  • No Thumbnail Available
    ItemMetadata only
    A hill tribe community advisory board in Northern Thailand: lessons learned one year on
    (2024-12-01) Perrone C.; Kanthawang N.; Cheah P.Y.; Perrone C.; Mahidol University
    Northern Thailand and its neighbouring regions are home to several minority ethnic groups known as hill tribes, each with their own language and customs. Hill tribe communities live mostly in remote agricultural communities, face barriers in accessing health, and have a lower socio-economic status compared to the main Thai ethnic group. Due to their increased risk of infectious diseases, they are often participants in our research projects. To make sure our work is in line with the interests of hill tribe communities and respects their beliefs and customs, we set up a hill tribe community advisory board. We consult the members before, during, and after our projects are carried out. This manuscript recounts how we set up the community advisory board and our reflections following one year of activities. Our experience strongly supports engaging with community advisory boards when working with minority ethnic groups in lower and middle-income settings. In particular, we found that over time, as researchers and members familiarise with one another and their respective environments, exchanges gain meaning and benefits increase, stressing the advantages of long-term collaborations over short or project-based ones.
  • No Thumbnail Available
    PublicationMetadata only
    An abundance of population-specific monomorphic SNPs may or may not be meaningful: A commentary on differences in allele frequencies of familial hypercholesterolemia SNPs in the Malaysian population
    (2012-07-01) Wanna Thongnoppakhun; Anunchai Assawamakin; Sissades Tongsima; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology
  • No Thumbnail Available
    PublicationMetadata only
    Acetazolamide aggravated diabetic ketoacidosis severity in a boy post-transplantation thalassaemia with intracranial hypertension
    (2020-01-01) Natee Sakornyutthadej; Pat Mahachoklertwattana; Nattachai Anantasit; Suradej Hongeng; Preamrudee Poomthavorn; Faculty of Medicine, Ramathibodi Hospital, Mahidol University
  • No Thumbnail Available
    PublicationMetadata only
    Achieving affordable critical care in low-income and middle-income countries
    (2019-06-01) Hugo C. Turner; Nguyen Van Hao; Sophie Yacoub; Van Minh Tu Hoang; David A. Clifton; Guy E. Thwaites; Arjen M. Dondorp; C. Louise Thwaites; Nguyen Van Vinh Chau; University of Oxford; UCL; Mahidol University; Nuffield Department of Clinical Medicine; Oxford University Clinical Research Unit
  • No Thumbnail Available
    ItemMetadata only
    Achieving COVID-19 herd immunity in Bangladesh
    (2023-06-01) Mary R.M.; Alam F.; Miranda A.V.; Lucero-Prisno D.E.; Bulbul M.M.I.; Mary R.M.; Mahidol University
    Achieving herd immunity against COVID-19 through vaccination is a global target, including in lower resource settings. Despite the challenges and limitations, Bangladesh has achieved its target of vaccinating 70% of its population, with good vaccine coverage among refugees, remote population, and women. This can be attributed to the evidence-informed adaptability and collaborative approaches of the program. Yet some challenges remain, including dependence on donors and the need to ramp up vaccination among the underserved communities. This article discusses the factors contributing to the achievements of the COVID-19 vaccination program of Bangladesh and the remaining challenges that should be addressed by the government to ensure the sustainability of the program and inform future vaccination efforts.
  • No Thumbnail Available
    PublicationMetadata only
    The Affordable Medicines Facility - Malaria: Killing it slowly
    (2012-12-01) Kenneth J. Arrow; Patricia M. Danzon; Hellen Gelband; Dean Jamison; Ramanan Laxminarayan; Anne Mills; Germano Mwabu; Claire Panosian; Richard Peto; Nicholas J. White; Stanford University; University of Pennsylvania, Wharton School; Center for Disease Dynamics, Economics and Policy; University of Washington, Seattle; London School of Hygiene & Tropical Medicine; University of Nairobi; David Geffen School of Medicine at UCLA; University of Oxford; Mahidol University
  • No Thumbnail Available
    ItemMetadata only
    African Medicines Agency: How it will change the landscape of medicines in Africa
    (2023-06-01) Ogbodum M.U.; Shomuyiwa D.O.; Lucero-Prisno D.E.; Gutu C.T.; Bouali H.; Bangura B.N.; Fofana M.; Musa M.B.; Daoud H.A.; Owusu-Mensah P.; Fiagan D.D.C.; Danquah C.A.; Samai M.; Ogbodum M.U.; Mahidol University
    The African continent, with a population of about 1.2 billion, faces limited access to safe, high-quality and effective medicine, resulting in a disproportionate disease burden. However, the scarcity of pharmaceuticals has been a significant problem for decades. The need to scale up local production of medicines in Africa is apparent, as over 70% of drugs available in the continent are imported. Africa's pharmaceutical manufacturing industry capacity is subpar due to inadequate production equipment and substandard operations. Inadequate pharmaceutical supplies encouraged the circulation of fake drugs, and the COVID-19 pandemic highlighted the dangers of the continent's reliance on foreign supplies. Africa's porous borders create ease for drug counterfeiting, with little likelihood of detection once in the supply chain. The African Medicines Agency (AMA) was founded to model the European Medicines Agency to enhance regional drug production, regulation and patient access. The African Union's AMA is a specialized health organization tasked with enhancing regulatory harmonization of medicines, particularly in pharmaceutical production, to increase access to high-quality medications across the continent. Africa's healthcare industry, particularly domestic pharmaceutical manufacturing, will be a significant economic engine for the continent over the next 5 years. The establishment of AMA is a call to action for governments and regulators to enable Africa to manufacture 60% of the vaccines needed on the continent by 2040.
  • No Thumbnail Available
    ItemMetadata only
    Afterword
    (2024-01-01) Forstenzer J.; Demissie F.; Boontinand V.; Forstenzer J.; Mahidol University
  • No Thumbnail Available
    PublicationMetadata only
    Age, exposure and immunity
    (2018-08-21) Michael White; James Watson; Mahidol University; Nuffield Department of Clinical Medicine; Institut Pasteur, Paris
    © 2018, White et al. The acquisition of immunity to malaria by an individual depends on their age and the number of infectious mosquito bites they have received.
  • No Thumbnail Available
    PublicationMetadata only
    Anaesthesia/analgesia for manual removal of retained placenta
    (2020-06-12) Kiattisak Kongwattanakul; Nonthida Rojanapithayakorn; Malinee Laopaiboon; Pisake Lumbiganon; Khon Kaen University; Faculty of Medicine, Siriraj Hospital, Mahidol University
    Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: As a retained placenta is a potential life-threatening obstetrical complication, effective and timely management is important. The estimated mortality rates from a retained placenta in developing countries range from 3% to 9%. One possible factor contributing to the high mortality rates is a delay in initiating manual removal of the placenta. Effective anaesthesia or analgesia during this procedure will provide adequate uterine relaxation and pain control, enabling it to be carried out effectively. Objectives: To assess the effectiveness and safety of general, regional, and local anaesthesia or analgesia during manual removal of a retained placenta. Search methods: We searched Cochrane Pregnancy and Childbirth’s Trials Register, ClinicalTrials.gov and the World Health Organization's International Clinical Trials Registry Platform to 30 September 2019, and reference lists of retrieved studies. Selection criteria: We sought randomised controlled trials (RCTs), quasi-randomised controlled trials, and cluster-randomised trials that compared different methods of preoperative or intraoperative anaesthetic or analgesic, administered during the manual removal of a retained placenta. Data collection and analysis: Two review authors independently assessed the study reports for inclusion, and risk of bias, extracted data and checked them for accuracy. We followed standard Cochrane methodology. Main results: We identified only one randomised controlled trial (N = 30 women) that evaluated the effect of paracervical block on women undergoing manual removal of a retained placenta compared with intravenous pethidine and diazepam. The study was conducted in a hospital in Papua New Guinea. The study was at high risk of bias of performance bias and detection bias, low risk of attrition bias, and an unclear risk of selection bias, reporting bias, and other bias. The included study did not measure this review's primary outcomes of pain intensity and adverse events. The study reported that there were no women, in either group, who experienced an estimated postpartum blood loss of more than 500 mL. We are uncertain about the providers' satisfaction with the procedure, defined as their perception of achieving good pain relief during the procedure (risk ratio (RR) 1.50, 95% confidence interval (CI) 0.71 to 3.16, one study, 30 women; very low quality evidence). We are also uncertain about the women's satisfaction with the procedure, defined as their perception of achieving good pain relief during the procedure (RR 0.82, 95% CI 0.49 to 1.37; one study, 30 women; very low quality evidence). The included study did not report on any of our other outcomes of interest. Authors' conclusions: There is insufficient evidence from one small study to evaluate the effectiveness and safety of anaesthesia or analgesia during the manual removal of a retained placenta. The quality of the available evidence was very low. We downgraded based on issues of limitations in study design (risk of bias) and imprecision (single study with small sample size, few or no events, and wide confidence intervals). There is a need for well-designed, multi-centre, randomised, controlled trials to evaluate the effectiveness and safety of different types of anaesthesia and analgesia during manual removal of a retained placenta. These studies could report on the important outcomes outlined in this review.
  • No Thumbnail Available
    PublicationMetadata only
    Analysis of N-glycan profile of Arabidopsis alg3 cell cultur
    (2021-01-01) Ratna Sariyatun; Hiroyuki Kajiura; Juthamard Limkul; Ryo Misaki; Kazuhito Fujiyama; Osaka University; Mahidol University
    N-Glycosylation is essential for protein stability, activity and characteristics, and is often needed to deliver pharmaceutical glycoproteins to target cells. A paucimannosidic structure, Man3GlcNAc2 (M3), has been reported to enable cellular uptake of glycoproteins through the mannose receptor (MR) in humans, and such uptake has been exploited for the treatment of certain diseases. However, M3 is generally produced at a very low level in plants. In this study, a cell culture was established from an Arabidopsis alg3 mutant plant lacking asparagine-linked glycosylation 3 (ALG3) enzyme activity. Arabidopsis alg3 cell culture produced glycoproteins with predominantly M3 and GlcNAc-terminal structures, while the amount of plant-specific N-glycans was very low. Pharmaceutical glycoproteins with these characteristics would be valuable for cellular delivery through the MR, and safe for human therapy.
  • No Thumbnail Available
    PublicationMetadata only
    Anatomy and physiology of the digestive system of the oarfish Regalecus russellii (Lampridiformes: Regalecidae)
    (2017-11-01) Tyson R. Roberts; Smithsonian Tropical Research Institute; Mahidol University
  • No Thumbnail Available
    ItemMetadata only
    Another antimalarial mass drug administration?
    (2025-01-01) von Seidlein L.; von Seidlein L.; Mahidol University
  • No Thumbnail Available
    ItemMetadata only
  • No Thumbnail Available
    ItemMetadata only
    Application of buccal mucosal graft to establish a new urination passage in male cats with penile traumatic injury
    (2022-01-01) Yala W.; Suranunt P.; Fujisawa Y.; Yippaditr W.; Mahidol University
    Two male cats were presented with penile part of urethra injury due to dog attacks to the perineum and genitalia area. Chronic wound around a remained penile part of urethra due to the dog bite and perineal area was evident due to urine irritation. The buccal mucosa was harvested and subsequently placed on the granulation tissue of the wound to reconstruct the urinary passage. The buccal mucosal graft completely attached to the skin and urethra without any complications. From the follow-up at 3 months, the cats were able to urinate normally and the skin irritation from urine was resolved. In summary, the buccal mucosa is a good graft source and is suitable for the reconstruction of the urinary passage in severe and complicated cases of penile part of urethra injury in male cats.