Scopus 2019
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Publication Metadata only Association Between Pretreatment Dietary Preference and Weight Loss after Radiation Therapy in Head and Neck Cancer Patients: A Pilot Study(2019-02-17) Kanoknun Vittayakasemsont; Chonsanee Klaitong; Kulachatr Phukosi; Visith Chavasit; Tanadej Sinthusek; Dunyaporn Trachootham; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University; Maha Vajiralongkorn Thanyaburi Hospital© 2019, © 2019 Taylor & Francis Group, LLC. Weight loss is common in cancer patients underwent radiation therapy. However, the impact of pretreatment behavior on postradiation nutritional status was unknown. This prospective observational study was conducted in 31 Thai head and neck cancer patients to investigate the association between pretreatment dietary preference and weight change after radiotherapy. Pretreatment preferences on sweet, salty, sour, bitter, umami, spicy, and fatty food were evaluated using a validated questionnaire, TASTE26. Body weights were monitored at baseline, 1,000–2,000, 2,800–3,400, 4,000–4,400, and 5,000–7,000 cGy of radiations and 2 month-follow up after radiotherapy. The energy intakes were analyzed by using 3 day-dietary record and INMUCAL software. Spicy food preference was the only factor found positively correlated with weight loss after radiation (r = 0.64, P = 0.007). Consistently, strong spicy lovers had more pronounced reduction of energy intake and body weight, and higher needs of tube feeding than those of mild or moderate lovers (P < 0.05). This study suggested that stronger preference on spicy food may be associated with less energy intake and more severe weight loss after radiation therapy. A large-scale study is warranted to confirm such findings. Then, preradiation screening for spicy preference may be useful to predict weight loss during radiation therapy.Publication Metadata only Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry(2019-03-01) Chanchal Chandramouli; Tiew Hwa Katherine Teng; Wan Ting Tay; Jonathan Yap; Michael R. MacDonald; Jasper Tromp; Limin Yan; Bambang Siswanto; Eugenio B. Reyes; Tachapong Ngarmukos; Cheuk Man Yu; Chung Lieh Hung; Inder Anand; A. Mark Richards; Lieng Hsi Ling; Judith G. Regensteiner; Carolyn S.P. Lam; A. Mark Richards; Carolyn S.P. Lam; Inder Anand; Chung Lieh Hung; Lieng Hsi Ling; Houng Bang Liew; Calambur Narasimhan; Sang Weon Park; Eugenio Reyes; Bambang B. Siswanto; Wataru Shimizu; Shu Zhang; Manila Doctors Hospital; Care Hospital Hyderabad; Universitas Indonesia; Mackay Memorial Hospital Taiwan; University of Colorado School of Medicine; Nippon Medical School; University of Otago; National University of Singapore; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; VA Medical Center; Changi General Hospital; University of Minnesota Medical School; University of Groningen, University Medical Center Groningen; National Heart Centre, Singapore; Chinese University of Hong Kong; Queen Elizabeth Hospital; Cardiovascular Research Institute; Fuwai Cardiovascular Hospital; Sejong General Hospital© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m 2 , P interaction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, P interaction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (P interaction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P < 0.001), in both DM and non-DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; P interaction = 0.005). Conclusions: Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.Publication Metadata only Teacher's quality of life in Yala province, Thailand(2019-03-01) Jesadaporn Pupantragul; Jutatip Sillabutra; Chukiat Viwatwongkasem; Prasong Kitidamrongsuk; Mahidol University© 2019 IEEE. Teachers are the key persons in successful of the educational system. The strengths and quality of the educational system are upon the quality of teachers and their performance. This study aims to determine the quality of life among teacher in Yala province. The quality of life (QoL) in Yala province is depicted by Quantum GIS (QGIS). The results show that teachers in primary educational service area 1 and 2 had a moderate level of QoL, and teachers in primary educational service area 3 had a good level of QoL. Teachers in all of the primary educational service area had a moderate level in the physical domain and environment domain. According to QoL in the psychological domain, teachers in primary educational service area 1 and 3 had a good level and those in primary educational service area 2 had a moderate level. Teachers in primary educational service area 3 were classified to a good level in social relationship. However, a moderate level of quality of life was found in primary educational service area 1 and 2. This study provides information about QoL among teachers in three different areas according to the primary educational services area. The information can be used for development planning to improve QoL among teacher in specific area of Yala.Publication Metadata only Permeability-surface area product of the penumbra as a predictor of outcome after endovascular treatment of anterior circulation acute ischemic stroke(2019-01-01) Dittapong Songsaeng; Athip Sangrungruang; Chulaluck Boonma; Timo Krings; University of Toronto Faculty of Medicine; Faculty of Medicine, Siriraj Hospital, Mahidol University© The Foundation Acta Radiologica 2019. Background: Permeability-surface product is a predictor of blood–brain barrier disruption, a condition that may be related to higher likelihoods of hemorrhagic transformations in acute stroke. Purpose: To investigate whether permeability-surface product can be used as a parameter for predicting outcome after mechanical thrombectomy in patients with anterior circulation acute ischemic stroke. Material and Methods: We retrospectively identified patients with acute middle cerebral artery stroke who underwent successful mechanical thrombectomy between November 2009 and July 2015. Multiple parameters (including age) and CT perfusion-related parameters (including permeability-surface product) were compared between patients with favorable (modified Rankin Scale [mRS] = 0–2) and unfavorable (mRS > 2) outcome. Results: Thirty patients were included, 50% having favorable and 50% having unfavorable outcome. Younger age was significantly associated with favorable outcome (P < 0.03). Other baseline characteristics, such as size of CT perfusion core infarction, perfusion abnormality, and presentation of subcortical infarction were not significantly different between groups. No significant difference was observed between groups for permeability-surface product in the ipsilateral penumbra or for the ratio between permeability-surface product penumbra value and contralateral normal brain (permeability-surface product ratio). Conclusions: No significant difference was observed between patients with and without favorable outcome after mechanical thrombectomy for either permeability-surface product value or permeability-surface product ratio. Although permeability-surface product is a good predictor of blood–brain barrier disruption, this study revealed no evidence that either permeability-surface product value or permeability-surface product ratio is associated with future change in the penumbra.Publication Metadata only A retrospective molecular study of Cryptosporidium species and genotypes in HIV-infected patients from Thailand(2019-03-12) Anna Rosa Sannella; Yupin Suputtamongkol; Ekkarat Wongsawat; Simone M. Cacciò; Faculty of Medicine, Siriraj Hospital, Mahidol University; Istituto Superiore Di Sanita© 2019 The Author(s). Background: Opportunistic infections represent a serious health problem for HIV-infected people. Among enteric infections, cryptosporidiosis, a severe and life-threatening diarrheal disease, is of particular importance in low economic settings where access to anti-retroviral therapy is limited. Understanding transmission routes is crucial in establishing preventive measures, and requires the use of informative genotyping methods. In this study, we performed a retrospective analysis of Cryptosporidium species in 166 stool samples collected from 155 HIV-infected patients during 1999-2004 at the Siriraj Hospital in Bangkok, Thailand. Results: Microscopic examination of stools identified 104 of the 155 patients as positive for Cryptosporidium. Other common pathogens identified were microsporidia, Isospora, Giardia, Strongyloides and Opisthorchis. All samples were tested by amplification of a fragment of the 18S rDNA locus, and sequencing showed the presence of Cryptosporidium hominis (n = 42), C. meleagridis (n = 20), C. canis (n = 12), C. felis (n = 7), C. suis (n = 6) and C. parvum (n = 5). Genotyping at the glycoprotein 60 (gp60) locus revealed substantial variability in isolates of C. hominis and C. meleagridis. Among C. hominis isolates, subtype IeA11G3T3 was the most prevalent, but allelic family Id was the more diverse with four subtypes described, two of which were identified for the first time. Among C. meleagridis isolates, seven subtypes, two of which were new, were found in the allelic family IIIb, along with new subtypes in allelic families IIIe and IIIg. In the four C. parvum isolates, subtype IIoA16G1, a rare subtype previously reported in a Swedish patient who had traveled to Thailand, was identified. Conclusions: This study confirms the high susceptibility of HIV-infected individuals to infection with different Cryptosporidium species and subtypes, and further stresses the importance of surveillance for opportunistic intestinal protozoans.Publication Metadata only Physicochemical and rheological properties of flour and starch from Thai pigmented rice cultivars(2019-09-15) Nuttinee Tangsrianugul; Rungtiwa Wongsagonsup; Manop Suphantharika; Mahidol University© 2019 Elsevier B.V. Flour and starch from four Thai pigmented rice cultivars, i.e., Riceberry (RB), Hom Nil (HN), Niaw Dang (ND), and Kum Pleuak Khao (KP) were compared for their physicochemical and rheological properties. Amylose content of all rice starches decreased in the following order: RB (12.09%) > HN (8.14%) > KP (2.87%) ~ ND (2.77%). The HN starch had the lowest proportion of amylopectin short A chains, while the KP starch showed the highest. Pasting temperature, setback, and final viscosity increased, while breakdown and swelling power decreased with increasing amylose content for both flour and starch samples. The flours and starches from the RB and HN showed greater onset and peak temperatures and enthalpy change (ΔH) of gelatinization than those from the ND and KP. Moreover, the gelatinization temperatures of all starches were significantly lower, but ΔH was higher than their flour counterparts. Dynamic viscoelastic tests revealed weak-gel like behavior of all flour and starch gels as evidenced by their G′ > G″ and tan δ values were smaller than unity.Publication Metadata only Urinary levels of phthalates and DINCH metabolites in Korean and Thai pregnant women across three trimesters(2019-01-01) Gowoon Lee; Sungmin Kim; Younglim Kho; Sunmi Kim; Seonyeong Lee; Gyuyeon Choi; Jiwon Park; Suwalee Worakhunpiset; Hyo Bang Moon; Kamolnetr Okanurak; Malee Geounuppakul; Jirat Tangtitawong; Kasem Wetsutthanon; Daungprateep Trisurat; Kyungho Choi; Eulji University; Hanyang University; Soonchunhyang University, College of Medicine; Seoul National University; Mahidol University; Metropolitan and Wellness Institute of Health; Cheongdam Yeon & Nature Obestetrics & Gynecology; CentralBio Co., Ltd.; Maternal and Child Health consultant; Korea Environmental Industry & Technology Institute; Boromarajonani College of Nursing© 2019 Elsevier B.V. Phthalates are anti-androgenic chemicals and may cause long-lasting adverse effects on growing fetuses. Understanding their exposure profile during pregnancy, therefore, is of public health importance. Because both behavioral and physiological changes of pregnant women are expected to be substantial, the amount of phthalate exposure is expected to vary significantly over the course of pregnancy. Temporal trend of phthalate exposure during pregnancy, however, is largely unknown, especially in Asian women. The purpose of this study is to investigate the urinary concentrations of metabolites for major phthalates and alternative plasticizers over the course of pregnancy among Korean (n = 81) and Thai women (n = 102). Twenty-four metabolites from 15 plasticizers, such as dimethyl phthalate (DMP), diethyl phthalate (DEP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzyl butyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), dioctyl phthalate (DnOP), diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP), di(2-ethylhexyl) terephthalate (DEHTP), and di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), were measured in urine samples collected in each trimester from pregnant women. While the levels of several phthalate metabolites were significantly different by trimester among Korean women, those of Thai women were relatively consistent. Urinary metabolites of DEP and DnOP were higher in Thai pregnant women compared to Korean pregnant women. The detection frequencies of the DINCH metabolite were 67.4% and 44.9% among Korean and Thai pregnant women, respectively. However, the ratio of DINCH to DEHP metabolites was significantly higher in Thai women. According to risk assessment, 11.9% of Korean and 5.3% of Thai women were considered at risk due to phthalate exposure, and DEHP, DnBP and DiBP were identified as major risk drivers. Considering the vulnerability of growing fetuses, further studies are warranted to identify major sources of exposure to these plasticizers during pregnancy.Publication Metadata only Safety, Pharmacokinetics, and Mosquito-Lethal Effects of Ivermectin in Combination With Dihydroartemisinin-Piperaquine and Primaquine in Healthy Adult Thai Subjects(2019-01-01) Kevin C. Kobylinski; Podjanee Jittamala; Borimas Hanboonkunupakarn; Sasithon Pukrittayakamee; Kanchana Pantuwatana; Siriporn Phasomkusolsil; Silas A. Davidson; Markus Winterberg; Richard M. Hoglund; Mavuto Mukaka; Rob W. van der Pluijm; Arjen Dondorp; Nicholas P.J. Day; Nicholas J. White; Joel Tarning; Armed Forces Research Institute of Medical Sciences, Thailand; Walter Reed Army Institute of Research; Mahidol University; Nuffield Department of Clinical Medicine; Royal Institute of Thailand© 2019 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics, and mosquito-lethal effects of combinations of ivermectin, dihydroartemisinin-piperaquine, and primaquine were evaluated. Coadministration of ivermectin and dihydroartemisinin-piperaquine resulted in increased ivermectin concentrations with corresponding increases in mosquito-lethal effect across all subjects. Exposure to piperaquine was also increased when coadministered with ivermectin, but electrocardiograph QT-interval prolongation was not increased. One subject had transiently impaired liver function. Ivermectin mosquito-lethal effect was greater than predicted previously against the major Southeast Asian malaria vectors. Both Anopheles dirus and Anopheles minimus mosquito mortality was increased substantially (20-fold and 35-fold increase, respectively) when feeding on volunteer blood after ivermectin administration compared with in vitro ivermectin-spiked blood. This suggests the presence of ivermectin metabolites that impart mosquito-lethal effects. Further studies of this combined approach to accelerate malaria elimination are warranted.Publication Metadata only Rural-urban health disparities among older adults in South Africa(2019-01-01) Karl Peltzer; Nancy Phaswana-Mafuya; Supa Pengpid; North-West University; Human Sciences Research Council of South Africa; Mahidol University© 2019. The Authors. Background: There are limited studies assessing rural-urban disparities among older adults in Africa including South Africa. Aim: This study explores rural-urban health disparities among older adults in a population-based survey in South Africa. Setting: Data for this study emanated from the 2008 study on 'Global Ageing and Adult Health (SAGE) wave 1' (N = 3280) aged 50 years or older in South Africa. Methods: Associations between exposure variables and outcome variables (health status variables and chronic conditions) were examined through bivariate analyses and multivariable logistic regression. Results: Rural dwellers were more likely to be older, black African and had lower education and wealth than urban dwellers. Rural and urban dwellers reported a similar prevalence of self-rated health status, quality of life, severe functional disability, arthritis, asthma, lung disease, hypertension, obesity, underweight, stroke and/or angina, low vision, depression, anxiety and nocturnal sleep problems. Adjusting for socio-demographic and health risk behaviour variables, urban dwellers had a higher prevalence of diabetes (OR: 2.36, 95% CI: 1.37, 4.04), edentulism (OR: 2.79, 95% CI: 1.27, 6.09) and cognitive functioning (OR: 1.91, 95% CI: 1.27, 2.85) than rural dwellers. Conclusion: There are some rural-urban health disparities in South Africa, that is, urban dwellers had a higher prevalence of diabetes, edentulism and cognitive functioning than rural ones. Understanding these rural-urban health variations may help in developing better strategies to improve health across geolocality in South Africa.Publication Metadata only Implementing and Using New Information Technology in Hospital Logistics(2019-01-09) D. Kritchanchai; P. Engelseth; S. Srisakunwan; Høgskolen i Molde; Mahidol University© 2018 IEEE. Both public and private hospitals in Tailand seek to improve and increase service sufficiency as well as opportunities in an increasingly competitive healthcare services market in Thailand. One of these strategies is to adopt new technology into various functions in the hospital. This research aims to study IT implementation in the hospital supply chain. A qualitative survey of 20 community hospitals in Thailand is conducted providing information on IT -enabled development in Information Management, Data Standardization, Inventory Management, Purchasing Process and Transportation Management. The results show that most of the hospitals with poor performance tend to lack of functions responsible for new information technology implementation. When IT is applied effectively, results show that it brings about performance gains in inventory, purchasing and transportation functions of the studied hospitals.Publication Metadata only Adjuvant trastuzumab regimen for HER2-positive early-stage breast cancer: a systematic review and meta-analysis(2019-08-03) Anne Julienne Genuino; Usa Chaikledkaew; Due Ong The; Thanyanan Reungwetwattana; Ammarin Thakkinstian; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Objective: Breast cancer remains to be the globally leading female cancer. About 15% to 20% of breast cancers have human epidermal growth factor receptor 2 (HER2)-positive tumors–a more aggressive breast cancer subtype with shortened survival. In the light of new and updated trial data on trastuzumab therapy for HER2-positive early-stage breast cancer (EBC), we conducted a systematic review and meta-analysis to update the pooling of its relative treatment effects. Methods: Systematic search was performed through Pubmed and Scopus to identify studies comparing survival outcomes and risks of heart toxicity effects of adjuvant trastuzumab with chemotherapy versus chemotherapy alone for HER2-positive EBC patients. Results: Based on the eight included studies in the review, combining trastuzumab with chemotherapy continues to show lowered death and relapse risks by one-third. The decision to initiate trastuzumab, however, needs to be prudently deliberated as two to three times more cardiotoxicity risk was shown to be associated with its use. Conclusion: Administering adjuvant trastuzumab in a weekly cycle concurrently with anthracycline-taxane chemotherapy regimen appears to be a preferable option to optimize its favorable effect in improving DFS and to prevent significantly higher risk for cardiotoxic effects.Publication Metadata only Comparison of Complications and Revisions After Sacral 2 Alar Iliac Screw and Iliac Screw Fixation for Sacropelvic Fixation in Pediatric and Adult Populations: Systematic Review and Meta-Analysis(2019-12-01) Gun Keorochana; Alisara Arirachakaran; Kittipong Setrkraising; Jatupon Kongtharvonskul; Police General Hospital; Bumrungrad International Hospital; Faculty of Medicine, Ramathibodi Hospital, Mahidol University© 2019 Elsevier Inc. Objective: This systematic review and meta-analysis aims to assess and compare the postoperative outcomes of iliac screw (IS) fixation versus sacral 2 alar iliac (S2AI) screw fixation in the adult and pediatric populations. Methods: We searched all comparative studies that compared postoperative outcomes of IS and S2AI fixation techniques for pelvic fixation from the PubMed and Scopus databases up to June 23, 2019. Results: Eleven of 951 studies (N = 632 patients) were eligible; 8, 10, 5, 6, 3, 7, 2, and 2 studies were included in pooling of postoperative complications, revisions, implant failure, screw breakage, screw prominence, wound dehiscence, wound infection, visual analog scale (VAS), and ambulatory status (AS), respectively. The IS technique had a statistically significant higher chance of postoperative complications, revisions, implant failure, screw breakage, screw prominent, wound dehiscence, and wound infection by 1.89 (95% confidence interval [CI], 1.48–2.40), 1.91 (95% CI, 1.29–2.82), 2.28 (95% CI, 1.55–3.35), 3.96 (95% CI, 1.46–10.75), 6.83 (95% CI, 2.54–18.37), 4.62 (95% CI, 1.32–16.25), and 3.03 (95% CI, 1.62–5.66), respectively compared with the S2AI fixation technique. In subgroup analysis, the IS technique had a statistically significant higher chance of postoperative complications and revisions of 1.65 (95% CI, 1.25–2.16) and 1.71 (95% CI, 1.03–2.84) in pediatric populations and 2.32 (95% CI, 1.60–3.38) and 1.94 (95% CI, 1.00–3.73) in the adult populations compared with the S2AI fixation technique. IS screw fixation had a lower AS of −0.40 (95% CI, −0.76 to −0.15) than did S2AI fixation in the adult and pediatric populations. However, there was no difference in pain VAS between both groups. Conclusions: Sacropelvic fixation with IS screw fixation had more postoperative complications and revisions and lower AS than did S2AI fixation.Publication Metadata only Sequential open-label study of the safety, tolerability, and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults(2019-01-01) Borimas Hanboonkunupakarn; Rob W. Van Der Pluijm; Richard Hoglund; Sasithon Pukrittayakamee; Markus Winterberg; Mavuto Mukaka; Naomi Waithira; Kesinee Chotivanich; Pratap Singhasivanon; Nicholas J. White; Arjen M. Dondorp; Joel Tarning; Podjanee Jittamala; Mahidol University; Nuffield Department of Clinical Medicine; Royal Society of Thailand© 2019 Hanboonkunupakarn et al. Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. New antimalarial compounds will not be generally available soon. Combining three existing antimalarials in the form of triple ACTs, including dihydroartemisinin (DHA)-piperaquine + mefloquine, is a potential treatment option for multidrug-resistant Plasmodium falciparum malaria. In a sequential openlabel study, healthy Thai volunteers were treated with DHA-piperaquine (120 to 960 mg), mefloquine (500 mg), and DHA-piperaquine + mefloquine (120 to 960 mg + 500 mg), and serial symptom questionnaires, biochemistry, full blood counts, pharmacokinetic profiles, and electrocardiographic measurements were performed. Fifteen healthy subjects were enrolled. There was no difference in the incidence or severity of adverse events between the three treatment arms. The slight prolongation in QTc (QT interval corrected for heart rate) associated with DHA-piperaquine administration did not increase after administration of DHA-piperaquine - mefloquine. The addition of mefloquine had no significant effect on the pharmacokinetic properties of piperaquine. However, coadministration of mefloquine significantly reduced the exposures to dihydroartemisinin for area under the concentration-time curve (-22.6%; 90% confidence interval [CI], -33.1, -10.4; P=0.0039) and maximum concentration of drug in serum (-29.0%; 90% CI, -40.6, -15.1; P=0.0079). Mefloquine can be added safely to dihydroartemisinin-piperaquine in malaria treatment.Publication Metadata only Entry Strategy and Export Marketing in Emerging Markets: A Small Player Case(2019-03-01) Peachayanant Lorvoralak; Winai Wongsurawat; Mahidol University; Asian Institute of Technology Thailand© 2019 Lahore University of Management Sciences. The internationalization of dominant market leaders such as Haier (China), Tata Group (India) and CEMEX (Mexico) in emerging economies has attracted immense amounts of interest among academic researchers. A less-explored area is how non-dominant, second-movers venture into the international market. How do small players connect with foreign customers while operating in the shadows of the industry leader? What decisions are serendipitous and what actions are deliberate? What are the key environmental factors and internal decisions that propel a secondary player to place more chips in the international market? This case study addresses these questions using an example of a construction material manufacturer from Southeast Asia. It is suitable as a discussion starter in an international business class, especially for topics such as entry strategy, export marketing and the organization of international business.Publication Metadata only Inpatient prevalence, burden and comorbidity of Takayasu's arteritis: Nationwide inpatient sample 2013–2014(2019-08-01) Patompong Ungprasert; Karn Wijarnpreecha; Wisit Cheungpasitporn; Charat Thongprayoon; Paul T. Kroner; Faculty of Medicine, Siriraj Hospital, Mahidol University; Mayo Clinic; University of Mississippi Medical Center; Mayo Clinic in Jacksonville, Florida© 2018 Elsevier Inc. Objectives: To investigate the inpatient prevalence, characteristics and comorbidities of patients admitted with Takayasu's arteritis (TAK) in the United States (US). Methods: Patients with TAK were identified within the Nationwide Inpatient Sample (NIS) database of the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient characteristics, comorbidities, resource utilization and expenditures was collected. A propensity-matched cohort of individuals without TAK was also created from the same database to serve as comparators. Results: A total of 2840 patients with TAK were identified from the database, corresponding to an inpatient prevalence of 4.6 cases per 100,000 admissions. Compared to the propensity-matched cohort of individuals without TAK, patients with TAK were found to have significantly increased odds of stroke (adjusted odds ratio (aOR): 4.66, 95% CI: 2.10−10.31, p < 0.01), aortic aneurysm (aOR: 40.76, 95% CI: 9.13−181.7, p < 0.01), aortic valvulopathy (aOR: 4.92, 95% CI: 2.09−11.55, p < 0.01) and peripheral vascular disease (aOR: 4.41, 95% CI: 1.22−3.32, p < 0.01). However, the mortality was not significantly different (aOR: 1.44, 95% CI: 0.58−3.61, p = 0.43). After adjusting for confounders, patients with TAK displayed a mean additional $11,275 (95% CI, $4946−$17,603) for total hospital costs and a mean additional $45,305 (95% CI, $23,063−$67,546) for total hospitalization charges when compared to patients without TAK. Conclusions: The inpatient prevalence of TAK was higher than what would be expected from the overall incidence. The mean total hospital costs and total hospitalization charges for a patient admitted with TAK were higher than patients without TAK. Analysis of comorbidities found significantly higher odds of several vascular comorbidities compared with a propensity-matched cohort of individuals without TAK.Publication Metadata only Potential application of CRISPR-Cas12a fluorescence assay coupled with rapid nucleic acid amplification for detection of white spot syndrome virus in shrimp(2019-10-15) Thawatchai Chaijarasphong; Thanyawit Thammachai; Ornchuma Itsathitphaisarn; Kallaya Sritunyalucksana; Rungkarn Suebsing; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology© 2019 Elsevier B.V. White spot disease (WSD), caused by white spot syndrome virus (WSSV), is among the most severe diseases of cultivated shrimp. Here, the CRISPR-Cas12a system coupled with nucleic acid amplification was optimized for the detection of WSSV. The CRISPR-Cas12a system was used to specifically cleave the WSSV amplicons, simultaneously releasing a quenched reporter molecule resulting in fluorescence that could be detected with a simple UV transilluminator or a microplate reader. This specific cleavage accompanied by fluorescence simultaneously revealed the presence of the amplicon and confirmed its identity, preventing false positive test results from non-specific amplicons. When coupled with PCR or recombinase polymerase amplification (RPA), the Cas12a platform was capable of detecting as few as 200 copies WSSV per reaction and displayed no cross-reactivity with other shrimp DNA viruses. The method was also un-interfered by the presence of large amounts of unrelated background DNA. Moreover, the RPA-Cas12a protocol from start to finish could be performed at a constant temperature near 37 °C and required <1 h, without the need for complex equipment. Overall, our results demonstrated that the CRISPR-Cas12a method is robust, specific, confirmatory, user-friendly and potentially adaptable for in-field diagnosis of shrimp diseases.Publication Metadata only Predictive factors for survival outcomes of high- risk febrile neutropenic patients: A 3-year study at a single center in Thailand(2019-01-01) Wannaphorn Rotchanapanya; Weerapat Owattanapanich; Nonlawan Chueamuangphan; Faculty of Medicine, Siriraj Hospital, Mahidol University; Chiangrai Prachanukroh Hospital© 2019, Siriraj Medical Journal. Objective: This study aimed to identify the risk factors associated with mortality in febrile neutropenic patients. Materials and Methods: This 3-year, single center, retrospective, observational study was conducted at Chiangrai Prachanukroh Hospital, Chiangrai Province, Thailand. The inclusion criteria consisted of a patient age of over 15 years and a diagnosis of febrile neutropenia. Results: Most of the 303 febrile neutropenic inpatients had a Multinational Association for Supportive Care in Cancer (MASCC) risk score < 21. The median length of stay was 6 days (interquartile range: 4-11 days). During 30 days of admission, 24.8% of the patients succumbed. In a univariate analysis, patients receiving G-CSF, the postchemotherapy- related group, patients with MASCC score > 16, and patients admitted in private had significantly higher survival rate. In a multivariate analysis, a MASCC score ≤ 16 and non-chemotherapy-related groups were associated with an increased mortality risk. Conclusion: The 30-day survival rate of febrile neutropenic patients in Thailand is seventy-five percent. Low MASCC score and non-chemotherapy-related neutropenia are associated with a higher risk of unfavorable outcomes.Publication Metadata only The effect of botulinum toxin type A in different dilution on the contraction of fibroblast—In vitro study(2019-10-01) Rungsima Wanitphakdeedecha; Arisa Kaewkes; Chanida Ungaksornpairote; Saowalak Limsaengurai; Uraiwan Panich; Woraphong Manuskiatti; Faculty of Medicine, Siriraj Hospital, Mahidol University© 2019 The Authors. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc. Background: Botulinum toxin type A (BoNT-A) may directly remodel dermal tissues or induce a loss of normal morphology and cytoplasmic retraction and spread. Intradermal injection was claimed to produce a dermo-lifting effect, including midface lifting by using low concentration with variable dilution. Objective: To understand how intradermal BoNT-A achieves tissue lifting, we examined different type of BoNT-A and their effects on dermal fibroblast contraction. Methods: Normal human dermal fibroblasts were treated with onabotulinumtoxin (ONA), abobotulinumtoxin (ABO), prabotulinumtoxinA (PRABO), incobotulinumtoxinA (INCO), and letibotulinumtoxin A (LETI) in dilutions used in real-world practice. Fifty fibroblasts per dilution were photographed and measured the length to demonstrate their contraction every 2 hours from baseline (0 hours) to 12 hours post-treatment. Results: ONA did not significantly decrease fibroblast lengths, at any timepoint or dilution. At 1:7 dilution ratios, ABO decreased fibroblast lengths after 2 hours and significantly after 10-12 hours. At 1:7, 1:8, 1:9, and 1:10 dilution, PRABO decreased length, and most rapidly at 1:7 and 1:8. At 1:6, 1:8, 1:9, and 1:10 dilution, INCO decreased lengths almost immediately. At 1:6 dilution, INCO decreased lengths almost immediately. At 1:7 dilution, INCO decreased lengths after 2-4 hours, while at 1:8, 1:9, and 1:10 dilution, INCO decreased lenghts nearly imediately. LETI decreased lengths at all dilutions except 1:9, with near-immediate effects at 1:6, 1:7, 1:8, and 1:10. At 1:4 dilution, LETI decreased lengths from 1 hour. Conclusions: Different commercial preparations of BoNT-A toxins cause different fibroblast contractions in vitro. Product selection and dilution used may affect the clinical outcome of intradermal injection of BoNT-A for face lifting.Publication Metadata only Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract(2019-01-01) Savita Chewchinda; Nantakarn Leakaya; Hitoshi Sato; Vilasinee Hirunpanich Sato; Showa University; Mahidol University© 2019 Center for Food and Biomolecules, National Taiwan University Background and aim: Maclura cochinchinensis (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated. Experimental procedure: This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice. Results: In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000 mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and α-glucosidase inhibition (IC50:1.53 ± 0.03 μg/mL). Conclusion: This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.Publication Metadata only Effect of Poly(Vinyl Alcohol) on thermoelectric properties of sodium cobalt oxide(2019-01-01) Chutima Oopathumpa; Direk Boonthuma; Siwaporn Meejoo Smith; Rajamangala University of Technology Krungthep; Mahidol University© 2019 Trans Tech Publications, Switzerland. Organic polymer composites are relatively simple to process and are therefore used in thermoelectric materials. The organic polymers are used as an adhesive agent between thermoelectric material grains. Thermoelectric effects of poly(vinyl alcohol) (PVA) composited with sodium cobalt oxide (NaxCoO2) were studied in this work. PVA is a low cost and an excellent biocompatibility polymer. High electrical conductivity, high Seebeck coefficient and low thermal conductivity are required in thermoelectric materials. As PVA is an insulating material, the PVA in between NaxCoO2 grain boundaries has an effect on the low electrical conductivity of NaxCoO2 composite. This results in a decrease in thermoelectric efficiency. However, PVA has been utilized to increase the Seebeck coefficient and also enhance thermoelectric efficiency. In order to improve the electrical conductivity of NaxCoO2 composite, released PVA was produced by furnace heating at 500 °C to eliminate PVA from NaxCoO2/PVA sample. The general thermoelectric parameters including the Seebeck coefficient, electrical conductivity and power factor of NaxCoO2/PVA and composite and PVA removal sample were compared. X-ray diffraction patterns (XRD) and scanning electron microscope (SEM) images were used to identify the phase identification and morphology study, respectively. The results showed that the PVA removal sample had higher electrical conductivity than the NaxCoO2/PVA sample. However, NaxCoO2/PVA sample had higher thermoelectric performance than the PVA removal sample because the NaxCoO2/PVA sample showed higher Seebeck coefficient and power factor.