Journal: Journal of Applied Animal Science (JAAS)
18347
Issued Date
2013
Resource Type
Language
tha
eng
eng
Rights
มหาวิทยาลัยมหิดล
Rights Holder(s)
คณะสัตวแพทยศาสตร์ มหาวิทยาลัยมหิดล
Journal Volumes
JAAS Volume 1
(2551)
JAAS Volume 2
(2552)
JAAS Volume 3
(2553)
JAAS Volume 4
(2554)
JAAS Volume 5
(2555)
Title
Journal of Applied Animal Science (JAAS)
Other Contributor(s)
Abstract
The Journal of Applied Animal Science (JAAS), is a peered review journal which published 2 numbers (January-June, July-December) a year by Faculty ofVeterinary Science, Mahidol University, accepts manuscripts presenting information for publication with this philosophy in mind.Articles published in JAAS include a broad range of research topics in veterinary science, animal science, animal husbandry, animalproduction and fundamental aspects of genetics, nutrition, physiology, and preparation and utilization of animal products. Articles typically report research with cattle, companion animals, goats, horses, pigs, and sheep; however, studies involving other farm animals,aquatic and wildlife species, and laboratory animal species that address fundamental questions related to livestock and companion animal biology will be considered for publication.
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105 results
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Now showing 1 - 10 of 105
Publication Open Access Anthelminthic effects of artemisinin and its derivatives(2013) Tawewan Tansatit; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceQinghao (Artemisia annua, L.), a famous herb from China, has been used in traditional Chinese medicine. Artemisinin, an active substance is extracted from the leaves and flowers of Qinghao, with a unique sesquiterpene lactone endoperoxide structure showing an antimalarial activity. Derivatives of artemisinin, artesunate and artemether, are the most widely used as antimalarial drugs. Since artemisinin not only possess antimalarial properties, but also active against various parasitic infection. Ongoing research on these compounds has been emphasized on the potential impact for anthelmintic treatment. Artemisinin derivatives exhibited a broad spectrum property against various trematodes, nematode, and cestode both in vitro and in vivo studies. These helminthocidal properties of artemisinin derivatives presented here provide further data for clinical investigations in the field trial study. However, a better understanding of action of artemisinin derivatives and their biomolecule target may contribute a promising possibility for clinical utility in anthelmintic application. Toxicity of artemisinin derivatives was less and was demonstrated in experimental animals with neurotoxicity and anemia.Publication Open Access Effects of the three flavonoids; kaempferol, quercetin, and myricetin on Baby hamster kidney (BHK-21) cells and Human hepatocellular carcinoma cell (HepG2) cells proliferations and total Erk1/2 protein expression(2017) Sookruetai Boonmasawai; Arpron Leesombun; Kridsada Chaichoun; Jarupha Taowan; Ladawan Sariya; Orathai Thongjuy; Mahidol University. Faculty of Veterinary ScienceKaempferol, quercetin, and myricetin were regarded as the potential therapeutic flavonoids in several types of cancers. And the cancer cell proliferations that were directly induced by MAPK/Erk signaling pathway had been the important target of cancer treatment. Thus, this study was investigated the anti-proliferative effects of these three flavonoids together with total Erk1/2 protein expressions on Human hepatocellular carcinoma cell (HepG2) and Baby hamster kidney cells (BHK-2). The data showed the cytotoxic effects of 100 μM kaempferol, 5 μM myricetin and 50 μM quercetin on BHK-21 cells at 24h. After same incubation time, kaempferol (5 μM), myricetin (1 μM) and quercetin (1 μM) could significantly inhibit HepG2 cell proliferations. By western blot analysis, kaempferol and myricetin could not affect Total Erk1/2 proteins expression. But quercetin obviously suppressed total Erk1/2 protein expression in HepG2 cells at 24h. In conclusion, all three flavonoids had significant inhibitory effects on Hepatocellular carcinoma cells without cytotoxic effects on normal fibroblast. And inhibitory effects of quercetin in cancer cell proliferation related to total Erk1/2 protein reduction.Publication Open Access Subtilisin-like proprotein convertases (SPCs); host enzymes controlled viral protein processing and maturation(2014) Kridsada Chaichoun; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceThe cellular subtilisin-like proprotein convertases (SPCs) are responsible for virion maturation process which occurs in secretory vesicles, primes virion maturation and viral infectivity. Eight SPCs, SPC1 (furin/PACE), SPC2 (PC2), SPC3 (PC1/PC3), SPC4 (PACE4), SPC5 (PC4), SPC6 (PC5/PC6A) and SPC7 (LPC/PC7/PC8) and PCSK9, were identified. The consensus substrate sequence is -RX(K/R)R▼X- (X can be any amino acid, ▼ represents the cleavage site). The conformational change of viral proteins can be triggered by a low pH in the endosomes, as in the case of influenza virus, or by the interaction with a secondary receptor protein at the cell surface, as the case of HIV. In flaviviruses, the functional roles of charged residues locate to the SPC consensus sequence in cleavage site of prM protein and provide cleavability affect to virus replication. Changes in the prM-cleavage level were associated with altered proportions of extracellular virions and subviral particles. The hemagglutinin (HA) protein is a critical determinant of the pathogenicity of avian influenza viruses, with a clear link between HA cleavability and virulence. The highly pathogenic avian influenza virus, in which contain high numbers of basic amino acid sequence at the HA cleavage site, can be converted to low numbers of basic amino acid sequence of a typical avirulent virus. The processing by SPCs is an important control mechanism for the biological activity of viral surface proteins. The molecular mechanisms underlying the recognition of SPCs by viral glycoproteins were described, including recent findings demonstrating differential SPC-recognition of viral and cellular substrates. Proteolytic activation of envelope glycoproteins is necessary for entry of viruses into the host cell and, hence, for their ability to undergo multiple replication cycles. Proteolytic cleavage is the first step in the activation of virus fusion proteins and is followed by a conformational change resulting in the exposure of the fusion domain. The conformational change can be triggered by a low pH in the endosomes, or by the interaction with a secondary receptor protein at the cell surface.Publication Open Access New branching patterns of the subclavian arteries found in Thai native dogs(2019) Rachanchai Chawangwongsanukun; Damri Darawiroj; Tuempong Wongtawan; ราชันชัย ฉวางวงศานุกูล; ดำริ ดาราวิโรจน์; เติมพงศ์ วงศ์ตะวัน; Mahidol University. Faculty of Veterinary Science. Department of Preclinic and Applied Animal Science; Mahidol University. Faculty of Veterinary Science. Laboratory of Veterinary Biomedicine; Chulalongkorn University. Faculty of Veterinary Science. Department of AnatomyThe majority of dogs in Thailand are Thai native dogs, but their anatomy is rarely recorded. In this study, we aimed to investigate the anatomical variation of subclavian arteries of dogs in Thailand. We observed 43 cadavers of Thai native dogs compared to 15 cadavers of other breeds during teaching veterinary anatomy. Four new branching patterns of subclavian arteries were found and named as type Va, Vb/Vd, VIb, and VIIb/ VIId. Type V had had vertebral artery as the first branch, then costocervical and superficial cervical arteries arose together. Type Vb/Vd, the internal thoracic artery arose opposite either to the costocervical trunk or the superficial cervical artery while type Va the internal thoracic artery arose after the superficial cervical artery, but not opposite to the costocervical trunk. VIIb/VIId was described as vertebral artery is the first branch and then common trunk of costocervical and superficial cervical arteries, the internal thoracic artery arose opposite either to the costocervical trunk or the superficial cervical artery. These new patterns accounted for 5.9% of Thai native dogs in this study. From the new patterns, we created the new model that cover all possible branching patterns of the subclavian artery (26 variations). Notably, the highest frequency of branching patterns in Thai native dogs was type I (60.5%), specifically type Ib (33.7%), which was also the major pattern for both sides of subclavian arteries and both sexes of dogs. Type Ib was described as the vertebral artery was the first branch, then the costocervical trunk, later the superficial cervical and the internal thoracic arteries arose oppositely. This knowledge is useful for veterinary anatomical education, physiology, imaging diagnosis, and the surgical treatment for canine thorax, particularly in Thai dogs.Publication Open Access Cyclooxygenase enzymes expression in the kidney(2014) Namphung Suemanotham; Mahidol University. Faculty of Veterinary Science. Department of Clinical Science and Public HealthChronic kidney disease (CKD) is one of a common cause of death in both human and animals. Persistent proteinuria of renal origin and systemic hypertension are clinical and biological findings that are usually associated with more progressive kidney disease. In human medicine, renal cyclooxygenase (COX) enzymes (especially COX-2) have been involved in the progression of CKD as one of the biological mechanism that modulates hypertension and/or proteinuria via their products, prostanoids. Furthermore, COX-2 has been proposed to play a pathophysiological role in experimental models of progressive renal injury. However, inhibition of COX enzyme activity by non-steroidal anti-inflammatory drugs (NSAIDs), when used in clinical practice to provide pain relief and anti-inflammatory effects, can lead to renal adverse effects. This is because the prostanoids generated by renal COX enzymes have important physiological roles in the kidney.Publication Open Access ความหลากหลายของค้างคาวที่อาศัยอยู่ในถ้ำในพื้นที่จังหวัดกาญจนบุรี(2555) ปุญญพัฒน์ เศษวิสัย; ธนศักดิ์ ช่างบรรจง; ตติยนุช แช่มใส; ศิริพร ตั้งสุดใจ; สุขุมาล ฤทธิ์เต็ม; ทิฆเวท เวฬุวนารักษ์; สินีนาถ เจียมทวีบุญ; ไพศิลป์ เล็กเจริญ; กนิษฐา ตันเชียงสาย; กนกพร ไตรวิทยากร; สุรชิต แวงโสธรณ์; รวงรัตน์ พุทธรงควัตร; กฤษฎา ใจชื้น; มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์. ศูนย์เฝ้าระวังและติดตามโรคจากสัตว์ป่า สัตว์ต่างถิ่นและสัตว์อพยพ; มหาวิทยาลัยมหิดล. สถาบันชีววิทยาศาสตร์โมเลกุลThe study of diversity of cave dwelling bats was conducted in Kanchanaburi Province using harp traps between April 2010 and July 2012. A total of 1,166 individuals belonging to 13 species from 8 genera and 7 families were recorded. Hog-nosed Bat (Craseonycteris thonglongyai), Croslet Horseshoe Bat (Rhinolophus coelophyllus) and Thomas's Horseshoe Bat (Myotis siligorensis) were the three most abundant species captured in the areas. Malayan Slit-faced Bat (Nycteris tragata) is new records for cave in Western Thailand. The bat species diversity in the underground cave was higher than the above ground cave. Results of this study provide information for future management and conservation of bats.Publication Open Access การใช้วัสดุชีวภาพเพื่อช่วยในการสร้างกระดูกทดแทนในสุนัข(2553) พิงพล จรูญรัตน์; มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์Publication Unknown Quality and quantity of Asian elephant (Elephas maximus) peripheral blood mononuclear cells isolated by polymer of sucrose or colloidal silica solution gradient centrifugation(2008) Porntep Gittipongsiri; Somphon Makpun; Teeraphong Phansod; Dulyatad Gronsang; Roschong Boonyarittichaikij; Witthawat Wiriyarat; Mahidol University. Faculty of Veterinary SciencePeripheral blood mononuclear cells (PBMCs) are useful in cellular immunology, infectious disease diagnosis and molecular genetics research. This study was aimed to determine an appropriated procedure for PBMCs isolation from an Asian elephant (Elephas maximus) by using gradient centrifugations method. The efficacy of four different density solutions including polymer of sucrose solution (Ficoll-Hypaque mixture) of density 1.077 and colloidal silica solution (Percoll) of density 1.077, 1.078 and 1.079 g/cm3 were compared in elephant PBMC separation. Quality and quantity of isolated PBMCs were estimated by using five parameters including cell purity, cell recovery rate, cell viability, viability of PBMCs after 5 days cultivation and total cell count. The results showed that the total cell count was significantly different among 4 treatments, in which Percoll with density 1.079 g/cm3 yielded the highest PBMCs (average = 3.94 X 107 cells/cm3) and highest PBMCs recovery rate (average = 82.61%). However, the purity, viability and viability of PBMCs after 5 days cultivation were not significantly different (P<0.05). In conclusion, Percoll with a density of 1.079 g/cm3 is the most suitable density gradient treatment for Asian elephant PBMCs isolation in both quantity and quality aspects.Publication Open Access ความชุกทางซีรั่มของการติดเชื้อบรูเซลลาในโคเนื้อ อำเภอไทรโยค จังหวัดกาญจนบุรี(2557) วิษณุ วงษ์สว่าง; สุวรรณา แสนยุติธรรม; เชาวลิต นาคทอง; มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์The objective of this study is a seroprevalence of Brucella spp. infection in beef cattle in Sai-Yok district, Karnchanaburi province. The serological methods were carried out using Rose Bengal Test (RBT) and indirect Enzyme-Linked Immunosorbent Assay (indirect-ELISA) in 300 beef. Results showed that 4.33% in individual prevalence for brucellosis, 30.43% in farms prevalence, 4.7% in a male beef, 4.18% in a female beef, and a male beef is more probable than a female beef (OR = 1.130, 95% CI = 0.339-3.774, P-value = 0.842). In addition, the prevalence was found that 5.21% in older three years old beef group, 1.42% in younger three years old beef group. Moreover, an older beef (> 3 years old beef group) is brucellosis more probable than a young beef (< 3 years old beef group) (OR = 3.798, 95% CI = 0.485 - 29.737, P-value = 0.204).Publication Open Access ความรู้พื้นฐานเกี่ยวกับเซลล์ต้นกำเนิดมีเซนไคม์เพื่อใช้ทางสัตวแพทย์(2558) ปริญญา สามารถ; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาล. ภาควิชาวิทยาภูมิคุ้มกันA stem cell is an undifferentiated cell that has special properties for two reasons (1) the ability to increase the number self-renewal and (2) the ability to be differentiated into many cell types, and can be classified into two types (1) embryonic stem cells and (2) adult stem cells. Recent reports found that the differentiated cells can be reprogrammed to embryonic stem-like cells known as induced pluripotent stem cells. In the field of veterinary medicine, much attention has been paid to mesenchymal stem cells (MSCs), one type of adult stem cells. Many reports reveal the success for treating animals; however, there are small number of research have been performed in Thailand. The advantages of using MSCs are it can be easily isolated and cultured, avoiding ethical problems, having little effect on host immune defense, low costs and can be further applied clinically. The limitations of using MSCs are purification, proliferation and differentiation capability. Therefore, a basic science of mesenchymal stem cells is very important for the research question and developments. Thailand should focus on clinical application for build the confidence and enhance the standard of veterinary medicine in Thailand in order to compare with veterinary profession from developed countries, especially innovative new treatment by using mesenchymal stem cells.