Journal Issue: JAAS Vol. 14 No. 2
4
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2564
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tha
eng
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คณะสัตวแพทยศาสตร์ มหาวิทยาลัยมหิดล
Journal Volume
JAAS Volume 14
(2564)
Articles
Assessment of Two New Commercial Rapid Tests for Canine N-terminal Pro-B-type Natriuretic Peptide to Distinguish the Severity of Mitral Valve Disease in Dogs
(2021) ณัฐพล เรียงวิโรจน์กิจ; วลาสินี ศักดิ์คำดวง; Nattapon Riengvirodkij; Walasinee Sakcamduang
N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a potential cardiac biomarker released
primarily from ventricular myocytes. Previous studies in dogs suggest that the NT-proBNP assay can be used to
distinguish dogs with respiratory signs between congestive heart failure and primary respiratory illnesses.
The objective of this study is to determine and assess the clinical sensitivity and specificity of the two new NT-proBNP immunoassay tests for distinguishing dogs affected by myxomatous mitral valve disease (MMVD)
between with and without congestive heart failure (CHF), as well as between dogs with MMVD and normal dogs.
Thirty-seven dogs were enrolled in this study. Thirty-two dogs were measured by the NT-proBNP immunoassay
test (Bionote®), including 11 healthy dogs, 11 dogs with MMVD stage B2 (absence of CHF) and 10 dogs with
MMVD stage C (presence of CHF). Twenty-eight dogs were measured by the NT-proBNP rapid detection kit
(Dianotech®), including 6 healthy dogs, 7 dogs with MMVD stage B2 and 15 dogs with MMVD stage C.
The median NT-proBNP concentration in dogs with MMVD stage C was significantly higher than the
median NT-proBNP concentration in dogs with MMVD stage B2 and normal healthy dogs (p-value <0.001).
The Receiver operating characteristic (ROC) curve analysis showed that serum NT-proBNP concentration could
differentiate dogs with CHF signs (MMVD stage C) from dogs without CHF signs (normal healthy dogs and
MMVD stage B2. The area under the curve (AUC) was 0.932 and 0.928 for NT-proBNP Bionote® and Dianotech®
test, respectively. It also could discriminate dogs affected by MMVD with CHF (MMVD stage C2) from dogs
affected by MMVD without CHF (MMVD stage B2) with AUC of 0.818 and 0.867 for NT-proBNP Bionote® and
Dianotech® tests, respectively. In conclusion, the results suggested that serum NT-proBNP concentrations
tests from both companies could discriminate between dogs affected by CHF from those without CHF and normal
healthy dogs with reasonable accuracy.
Population Assessment of Crocodiles in Bueng Boraphet, Thailand
(2021) Parntep Ratanakorn; Tatiyanuch Chamsai; Poonyapat Sedwisai; Tat Sujittosakul; Thanaphum Lapjatuporn; Peerawat Wongluechai; Ekasit Tiyanun; Akalak Kunsorn; Somsook Puangdee; Thaweesak Chooma; Kadsirin Mattayasap; Phimchanok Srongmonkol; Jiradej Boonmak; Nareerat Sangkachai
This study aimed to estimate the number and distribution of crocodiles in Bueng Boraphet, Nakhon Sawan
Province, Thailand. The surveys were conducted between November 2017 and August 2018. The data was
obtained from nighttime spotlight and daylight visual surveys using motorboat along two line transects totaling
38 kilometers and covered an area about 7.6 square kilometers of Bueng Boraphet coastal area. Our results
revealed that the number of crocodiles was at least 17 individuals with density of 2.24 individuals per square
kilometers. The calculated population of crocodiles in the Bueng Boraphet was estimated to be about 17-37
individuals. In this study, most crocodiles were found in the first transect line located in the aquatic sanctuary
area where all fishery is strictly prohibited. It shows that human activities directly affect crocodile encounters and
these small numbers of crocodiles in Bueng Boraphet remain critically endangered. Therefore, the implementation
of protection action is a high-priority project that needs to be done first before further restocking can be
undertaken. Bueng Boraphet can be developed into national natural crocodile conservation, while eco-tourism
activities can be expanded in such area. Furthermore, population surveys should be carried out continuously
to determine population dynamics and develop a crocodile surveillance system. At the same time community
engagement should be initiated to support the system to sustainable conservation.
Case Report: Long-Term Management of Imidacloprid-Moxidectin in a Dog with Caval Syndrome
(2021) Panyakamol Chandrasakha; Rungrote Osathanon; Namphung Suemanotham
Caval syndrome is a condition from heavy heartworm infestations, causing intracardiac obstruction,
potentiating in multiple fatal complications, and poor prognosis. Early diagnosis is imperative for prompt
treatment and echocardiography has the benefit of aiding in exploring the cardiac structure and the worm
burden. According to The American Heartworm Society guideline (2020), it has established several treatment
regimens both medical and surgical. The purpose of this case report is to determine the clinical efficacy of
long-term macrocyclic lactone in the treatment of heartworm in a dog with caval syndrome. An 8-year-old
female French bulldog was presented with ascites. Numerous heartworms were detected intracardiac from an
echocardiography. A monthly application of 10% imidacloprid and 2.5% moxidectin with 4 weeks of 10 mg/kg
doxycycline had shown the efficacy in controlling heartworms of a dog with caval syndrome thus far, along with
an exercise restriction to prevent complication from pulmonary thromboembolism. Reassessment of this patient
was planned for a monthly health screening and a 3-month echocardiography for worms migration, thrombi, and
antigen testing. After 3 months, the worms were unable to detect from echocardiography and the dog was no
longer required abdominocentesis. The dog is currently living well and planned on giving a regular heartworm
prevention program after 12 months.
Surgical Ligation of Patent Ductus Arteriosus in an Adult Pomeranian
(2021) Kornrawee Tharavanij; Nattapon Riengvirodkij
Patent ductus arteriosus (PDA) is the most common congenital heart disease in dogs. The ductus arteriosus
extends from the main pulmonary artery to the descending aorta, shunting blood away from the nonfunctional
lungs in neonates. When it fails to constrict after birth, oxygenated blood can flow from the aorta to the pulmonary
artery. Most of untreated patients develop congestive heart failure at one year of age. The treatment options
include both minimally invasive and open surgical techniques. It is recommended that PDA be promptly closed
after diagnosis as immature dogs are the best candidates for surgery. An adult Pomeranian with PDA was
referred to Prasu-Arthorn Animal Hospital, Faculty of Veterinary Science, Mahidol University. An open surgical
ligation was performed at the animal hospital with the cooperation of a diplomate of the Thai Board of
Thoracic Surgery from the Faculty of Medicine Ramathibodi Hospital, Mahidol University. No intraoperative
complications occurred. Postoperative echocardiograms showed no residual flow, and there was a gradual
decrease in heart size three days to two months after surgery. The dog was more energetic and healthier.
Title
JAAS Vol. 14 No. 2
Author's Affiliation
มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์