Journal Issue: JAAS Vol. 7 No. 3
3
Issued Date
2557
Resource Type
Language
tha
eng
eng
File Type
application/pdf
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
คณะสัตวแพทยศาสตร์ มหาวิทยาลัยมหิดล
Journal Volume
JAAS Volume 7
(2557)
Articles
Cyclooxygenase enzymes expression in the kidney
(2014) Namphung Suemanotham; Mahidol University. Faculty of Veterinary Science. Department of Clinical Science and Public Health
Chronic kidney disease (CKD) is one of a common cause of death in both human and animals.
Persistent proteinuria of renal origin and systemic hypertension are clinical and biological findings that are
usually associated with more progressive kidney disease. In human medicine, renal cyclooxygenase (COX)
enzymes (especially COX-2) have been involved in the progression of CKD as one of the biological mechanism
that modulates hypertension and/or proteinuria via their products, prostanoids. Furthermore, COX-2 has been
proposed to play a pathophysiological role in experimental models of progressive renal injury. However,
inhibition of COX enzyme activity by non-steroidal anti-inflammatory drugs (NSAIDs), when used in clinical
practice to provide pain relief and anti-inflammatory effects, can lead to renal adverse effects. This is because
the prostanoids generated by renal COX enzymes have important physiological roles in the kidney.
Title
JAAS Vol. 7 No. 3
Author's Affiliation
มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์