Publication: Cyclooxygenase enzymes expression in the kidney
1
Issued Date
2014
Resource Type
Language
eng
ISSN
1906-2257
Rights
Mahidol University
Rights Holder(s)
Faculty of Veterinary Science Mahidol University
Bibliographic Citation
Journal of Applied Animal Science. Vol.7, No.3 (2014), 9-22
Suggested Citation
Namphung Suemanotham Cyclooxygenase enzymes expression in the kidney. Journal of Applied Animal Science. Vol.7, No.3 (2014), 9-22. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13340
Research Projects
Organizational Units
Authors
Journal Issue
JAAS Vol. 7 No. 3
(2557)
Thesis
Title
Cyclooxygenase enzymes expression in the kidney
Alternative Title(s)
การแสดงออกของเอนไซม์ Cyclooxygenase ในไต
Author(s)
Abstract
Chronic kidney disease (CKD) is one of a common cause of death in both human and animals.
Persistent proteinuria of renal origin and systemic hypertension are clinical and biological findings that are
usually associated with more progressive kidney disease. In human medicine, renal cyclooxygenase (COX)
enzymes (especially COX-2) have been involved in the progression of CKD as one of the biological mechanism
that modulates hypertension and/or proteinuria via their products, prostanoids. Furthermore, COX-2 has been
proposed to play a pathophysiological role in experimental models of progressive renal injury. However,
inhibition of COX enzyme activity by non-steroidal anti-inflammatory drugs (NSAIDs), when used in clinical
practice to provide pain relief and anti-inflammatory effects, can lead to renal adverse effects. This is because
the prostanoids generated by renal COX enzymes have important physiological roles in the kidney.