Publication: Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus
Issued Date
2018-01-01
ISSN
15221709
15209512
15209512
Other identifier(s)
2-s2.0-85057028025
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Sleep and Breathing. (2018)
Suggested Citation
Chutintorn Sriphrapradang, Sittichai Pinyopodjanard, Onnicha Suntornlohanakul, Hataikarn Nimitphong, Naricha Chirakalwasan, Sunee Saetang, Thunyarat Anothaisintawee, Nantaporn Siwasaranond, Areesa Manodpitipong, La Or Chailurkit, Sirimon Reutrakul Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus. Sleep and Breathing. (2018). doi:10.1007/s11325-018-1756-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47214
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus
Abstract
© 2018, Springer Nature Switzerland AG. Purpose: Hypothyroidism is associated with a high frequency of obstructive sleep apnea (OSA). However, the prevalence of OSA in hypothyroid patients is not different from the general population in many reports. The importance of thyroid function screening in sleep-disordered breathing is still controversial. This study aimed to explore the association between thyroid dysfunction and OSA in the adults with prediabetes or diabetes mellitus type 2, who have very high prevalence of OSA. Methods: OSA was assessed using an in-home monitoring device, WatchPAT200. OSA severity was measured using apnea-hypopnea index (AHI), oxygen desaturation index (ODI), minimum oxygen saturation (minO2), and time spent under oxygen saturation < 90% (T90). Patients with pre-existing thyroid dysfunction were excluded. Results: Participants included 70 men and 118 women with mean age 52.8 ± 10.9 years and body mass index 28.2 ± 4.9 kg/m 2 . One hundred forty participants (75%) had OSA, with a median AHI of 10.1 (interquartile range 4.8, 18.3). The percentage of positive thyroid autoantibody (thyroperoxidase and thyroglobulin antibody) was similar among the subjects with and without OSA. There was no correlation between the levels of thyroid function (TSH, FT3, FT4, TSH/FT3, and TSH/FT4 ratio) and the severity indices of OSA (AHI, ODI, minO2, and T90). Conclusions: These data do not support universal screening for thyroid dysfunction in OSA patients with diabetes or prediabetes.
