Scopus 2018
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Publication Metadata only Exploring one loop amplitude at four-points vertices by the OPP method(2018-12-19) Suppanat Supanyo; Udom Robkob; Mahidol University© Published under licence by IOP Publishing Ltd. We construct the general formula of one-loop amplitude at four-point vertices using Ossola, Papadopoulos, and Pittau (OPP) method. The incoming and outgoing particles are defined as arbitrary massless particles, and the intermediate state contains arbitrary particles inside. In this works, the amplitude is reconstructed via finding four-type rational coefficients. First, box coefficient is extracted using the four-cut technique with linear algebra. We found that triangle and bubble coefficients can be extracted using three-cut and two-cut technique with Cauchy residue theorem instead of with discrete Fourier sum like the original version of the OPP. Tadpole coefficient can be dropped out, because its scalar integral, which contains only UV divergence, is completely absorbed by renormalization.Publication Metadata only Significance of microscopic residual tumor in adenocarcinoma of stomach and esophagogastric junction after gastrectomy with d2 lymphadenectomy(2018-03-01) Thammawat Parakonthun; Narathip Parichardsombat; Hugo Salomon Rosero Paredes; Chainarong Phalanusittheph; Voraboot Taweerutchana; Atthaphorn Trakarnsanga; Jirawat Swangsri; Thawatchai Akaraviputh; Asada Methasate; Vitoon Chinswangwatanakul; Faculty of Medicine, Siriraj Hospital, Mahidol University; Hospital de Especialidades Eugenio Espejo© 2018, Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: Microscopic residual tumor (R1 resection) may have a significant negative impact on prognosis of patients with adenocarcinoma of stomach and esophagogastric junction. Results of R1 resection on survival and recurrence patterns have not yet been thoroughly investigated in Thailand. The aim of this study was to study the oncological outcomes of R1 resection after curative intended surgery. Methods: We retrospectively analyzed the medical records of patients who underwent curative intended surgery from 2005 to 2013 at Siriraj Hospital. Results: 162 patients underwent curative intended gastrectomy with radical lymphadenectomy. 122 (75.3%) patients received R0 resection (non-residual group), 40 (24.7%) patients had microscopic residual tumor (residual group). Microscopic residual tumor was associated with tumor size (p=0.008), tumor extension (p=0.028), pT-stage (p=0.012), pN-stage (p=0.012), and AJCC/TNM stage (p<0.001). Large tumor size (≥5 cm.) and number of metastatic lymph nodes (≥3 nodes) were the factors contributing to higher rate of microscopic residual tumor on multivariate analysis (p=0.024 and 0.039, respectively). Median overall survival of non-residual and residual groups were 34.6 and 16.4 months (p=0.065). Median disease-free survival of non-residual and residual groups were 13.2 and 10.2 months (p=0.099). Distant metastasis was the most common site of recurrence in both groups. R1 resection was associated with worse 5-year survival rate (17.5% vs 34.0%, p=0.049). Conclusion: Microscopic residual tumor was associated with larger tumor size and more number of metastatic lymph nodes. R1 resection resulted in worse prognosis. Distant metastasis was the most common site of recurrence, therefore, we might suggest systemic chemotherapy as an adjuvant treatment after curative intended surgery.Publication Metadata only Botulinum toxin for motor and phonic tics in Tourette's syndrome(2018-01-05) Sanjay Pandey; Prachaya Srivanitchapoom; Richard Kirubakaran; Brian D. Berman; Mahidol University; University of Colorado Health Sciences Center; G.B. Pant Hospital India; Christian Medical College, Vellore© 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Gilles de la Tourette syndrome, or Tourette's syndrome, is defined as the presence of both motor and vocal (phonic) tics for more than 12 months, that manifest before the age of 18 years, in the absence of secondary causes. Treatment of motor and phonic tics is difficult and challenging. Objectives: To determine the safety and effectiveness of botulinum toxin in treating motor and phonic tics in people with Tourette's syndrome, and to analyse the effect of botulinum toxin on premonitory urge and sensory tics. Search methods: We searched the Cochrane Movement Disorders Group Trials Register, CENTRAL, MEDLINE, and two trials registers to 25 October 2017. We reviewed reference lists of relevant articles for additional trials. Selection criteria: We considered all randomised, controlled, double-blind studies comparing botulinum toxin to placebo or other medications for the treatment of motor and phonic tics in Tourette's syndrome for this review. We sought both parallel group and cross-over studies of children or adults, at any dose, and for any duration. Data collection and analysis: We followed standard Cochrane methods to select studies, assess risk of bias, extract and analyse data. All authors independently abstracted data onto standardized forms; disagreements were resolved by mutual discussion. Main results: Only one randomised placebo-controlled, double-blind cross-over study met our selection criteria. In this study, 20 participants with motor tics were enrolled over a three-year recruitment period; 18 (14 of whom had a diagnosis of Tourette's syndrome) completed the study; in total, 21 focal motor tics were treated. Although we considered most bias domains to be at low risk of bias, the study recruited a small number of participants with relatively mild tics and provided limited data for our key outcomes. The effects of botulinum toxin injections on tic frequency, measured by videotape or rated subjectively, and on premonitory urge, are uncertain (very low-quality evidence). The quality of evidence for adverse events following botulinum toxin was very low. Nine people had muscle weakness following the injection, which could have led to unblinding of treatment group assignment. No data were available to evaluate whether botulinum injections led to immunoresistance to botulinum. Authors' conclusions: We are uncertain about botulinum toxin effects in the treatment of focal motor and phonic tics in select cases, as we assessed the quality of the evidence as very low. Additional randomised controlled studies are needed to demonstrate the benefits and harms of botulinum toxin therapy for the treatment of motor and phonic tics in patients with Tourette's syndrome.Publication Metadata only Ureterocystoplasty in a girl with bilateral ureterovesical junction obstructions and small bladder capacity: The first case report of Thailand(2018-07-01) Chaiyong Nualyong; Bansithi Chaiyaprasithi; Thawathai Mankongsrisuk; Santosh Shrestha; Kittipong Phinthusophon; Faculty of Medicine, Siriraj Hospital, Mahidol University; Western Regional Hospital© 2018, Siriraj Medical Journal. Objective: Ureterocystoplasty is one of the treatment options for small bladder capacity with hydroureter. To the best of our knowledge, there was no report of a patient who underwent this procedure in Thailand. Case presentation: A 4-year-old girl, who presented with obstructive anuria at birth was diagnosed with bilateral ureteropelvic junction obstruction and small bladder capacity. At the age of 2 years old, she underwent a teapot ureterocystoplasty with left to right transuretero-ureterostomy with right ureteral reimplantation. Postoperative complication was observed. The bladder capacity was evaluated and kidney ultrasonography was done during the follow up. There was no complication during the perioperative period. The bladder capacity was increased from 25 ml to 240 mL in 2 years postoperatively. Both kidneys also showed the decrease in degree of hydronephrosis. Conclusion: Ureterocystoplasty is a favorable treatment option for the patients with small bladder capacity and marked hydroureter. The procedure itself is not difficult to perform. Moreover, there are no mucous related complications and metabolic disturbances.Publication Metadata only Fever, rash, and red eyes in Thailand: A diagnostic challenge(2018-07-01) Hisham Ahmed Imad; Kamolthip Atsawawaranunt; Chollasap Sharma; Thitiya Poonam; Watcharapong Piyaphanee; Mahidol UniversityPublication Metadata only Expert opinion on the applicability of dyslipidemia guidelines in Asia and the middle east(2018-01-01) Mostafa Alshamiri; Mahmood Mohammed Ali Ghanaim; Philip Barter; Kuan Cheng Chang; Jian Jun Li; Bien J. Matawaran; Anwar Santoso; Sameh Shaheen; Ketut Suastika; Nuntakorn Thongtang; Ahmad K.M. Yusof; University of Santo Tomas, Manila; Dubai Hospital; Universitas Udayana; Universitas Indonesia; University of New South Wales (UNSW) Australia; Fuwai Hospital; Institut Jantung Negara Kuala Lumpur; Ain Shams University, Faculty of Medicine; King Saud University; Faculty of Medicine, Siriraj Hospital, Mahidol University; China Medical University Taichung© 2018 Alshamiri et al. Cardiovascular disease (CVD) is a growing burden across the world. In Asia and the Middle East, in particular, CVD is among the most prevalent and debilitating diseases. Dyslipidemia is an important factor in the development of atherosclerosis and associated cardiovascular events, and so effective management strategies are critical to reducing overall cardiovascular risk. Multiple dyslipidemia guidelines have been developed by international bodies such as the European Society of Cardiology/European Atherosclerosis Society and the American College of Cardiology/American Heart Association, which all have similarities in practice recommendations for the optimal management of dyslipidemia. However, they differ in certain aspects including pharmacological treatment, lifestyle modification and the target levels used for low-density lipoprotein cholesterol. The evidence behind these guidelines is generally based on data from Western populations, and their applicability to people in Asia and the Middle East is largely untested. As a result, practitioners within Asia and the Middle East continue to rely on international evidence despite population differences in lipid phenotypes and CVD risk factors. An expert panel was convened to review the international guidelines commonly used in Asia and the Middle East and determine their applicability to clinical practice in the region, with specific recommendations, or considerations, provided where current guideline recommendations differ from local practice. Herein, we describe the heterogeneous approaches and application of current guidelines used to manage dyslipidemia in Asia and the Middle East. We provide consensus management recommendations to cover different patient scenarios, including primary prevention, elderly, chronic kidney disease, type 2 diabetes, documented CVD, acute coronary syndromes and family history of ischemic heart disease. Moreover, we advocate for countries within the Asian and Middle East regions to continue to develop guidelines that are appropriate for the local population.Publication Metadata only A simple and practical amniocentesis model and the procedure success rate after training(2018-01-01) Pharuhas Chanprapaph; Nantivadee Mamuang; Sanitra Anuwutnavin; Faculty of Medicine, Siriraj Hospital, Mahidol University; Charoen Krung Pracharak Hospital© 2018, Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: To compare success rate of amniocentesis between model trained and non-model trained groups. Methods: Siriraj amniocentesis simulator was practiced by 5 inexperienced obstetric residents. Forty aspirations of red solution from the targeted balloons using spinal needle number 20-G under the ultrasound guidance were performed. Thereafter, each trainee was allowed to perform the real amniocentesis under an expert supervision within a 5-minute period. Amniocentesis success rate of previous 5 non-model trained residents was retrospectively reviewed and considered as the control group. Results: A comparison between each group was done to evaluate the success rate. There were 31 and 29 of amniocenteses performed by model trained and non-model trained groups, respectively. In comparison, the former had a nonsignificantly higher success rate (96.8% vs 82.2%; p > 0.05) with a significantly shorter operating time (34.27 ± 21.7 vs 73.38 ± 68.5 seconds; p < 0.05) than the latter. No obstetric adverse outcome was observed in both groups. Conclusion: The amniocentesis-training program with model is beneficial for the beginners to develop their skill prior to the real practice, especially shorter operating time. There was a trend of higher success rate in the modeltraining group.Publication Metadata only Protective effect of α-mangostin on high glucose induced endothelial cell apoptosis(2018-08-01) Kanjana Jittiporn; Primchanien Moongkarndi; Jutima Samer; Wisuda Suvitayavat; Naresuan University; Mahidol University© 2018, Walailak University. All rights reserved. α-mangostin is a phenolic compound from pericarp of mangosteen. It has prominent anti-oxidant properties. Oxidative stress has been shown to be a major factor that disrupts cell functions including endothelium. High glucose (HG) induced ROS production plays a key role in endothelial cell apoptosis. However, the effect of α-mangostin on HG induced apoptosis has not been studied yet. This study demonstrates the effect of α-mangostin in HG induced human umbilical vein endothelial cells (HUVECs) apoptosis. The non-toxic dose of α-mangostin was determined using a MTT assay. Intracellular reactive oxygen species (ROS) and cell apoptosis were evaluated using DCF-DA and TUNEL assays, respectively. The signaling of α-mangostin was elucidated by western blotting. α-mangostin significantly and, dose-dependently, decreased HG induced ROS formation. Also, α-mangostin significantly attenuated HG induced endothelial cell apoptosis. In addition, α-mangostin suppressed HG induced apoptosis via JNK and p38-MAPK. According to our results, α-mangostin attenuated HG induced endothelial cell apoptosis through inhibition of phosphorylation of JNK and p38-MAPK.Publication Metadata only A Comparative Study of Psychosocial Interventions for Internet Gaming Disorder Among Adolescents Aged 13–17 Years(2018-01-01) Chanvit Pornnoppadol; Woraphat Ratta-apha; Sirinda Chanpen; Supattra Wattananond; Nootchanet Dumrongrungruang; Kanthip Thongchoi; Suphaphorn Panchasilawut; Benyapa Wongyuen; Apakorn Chotivichit; Juntira Laothavorn; Asara Vasupanrajit; Faculty of Medicine, Siriraj Hospital, Mahidol University; Emory University© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The present study is a quasi-experimental, prospective study of interventions for internet gaming disorder (IGD). One hundred four parents and their adolescent children were enrolled and allocated to one of the four treatment groups; 7-day Siriraj Therapeutic Residential Camp (S-TRC) alone, 8-week Parent Management Training for Game Addiction (PMT-G) alone, combined S-TRC and PMT-G, and basic psychoeducation (control). The severity of IGD was measured by the Game Addiction Screening Test (GAST). The mean difference among groups in GAST scores was statistically significant, with P values of < 0.001, 0.002, and 0.005 at 1, 3, and 6 months post-intervention, respectively. All groups showed improvement over the control group. The percentage of adolescents who remained in the addicted or probably addicted groups was less than 50% in the S-TRC, PMT-G, and combined groups. In conclusion, both S-TRC and PMT-G were effective psychosocial interventions for IGD and were superior to basic psychoeducation alone.Publication Metadata only The first ethnic Asian case report of Paget’s disease with concomitant primary and secondary hyperparathyroidism(2018-04-01) Nantaporn Siwasaranond; Vorachai Sirikulchayanonta; Suphaneewan Jaovisidha; Hataikarn Nimitphong; Rangsit University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University© 2018, Medical Association of Thailand. All rights reserved. The authors report a case of Paget’s disease [PD] with concomitant primary hyperparathyroidism [PHPT] in a 63-year-old Thai female who presented with elevation of alkaline phosphatase [ALP] from the routine annual check-up. The plain film and bone scintigraphy revealed a solitary Paget’s lesion, characterized by osteolytic area, thicken cortex and prominent trabeculations in the right proximal femur. Further investigations revealed low level of 25-hydroxyvitamin D [25-(OH)D], elevation of calcium and parathyroid hormone [PTH] levels. A nodule in the right parathyroid gland was found. The serum calcium and PTH turned to normal after removal of the nodule, which was histologically diagnosed as parathyroid adenoma. Bisphosphonate was then given for treatment of Paget’s disease to prevent fracture. The case of Paget’s disease with concomitant parathyroid adenoma has not been previously reported in ethnic Asian groups. It is important to address that this concomitance is possible even in the countries where Paget’s disease is rare, so that appropriate management is not overlooked.Publication Metadata only Scrub typhus point-of-care testing: A systematic review and meta-analysis(2018-03-26) Kartika Saraswati; Nicholas P.J. Day; Mavuto Mukaka; Stuart D. Blacksell; Eijkman Institute for Molecular Biology; Mahidol University; Nuffield Department of Clinical Medicine© 2018 Saraswati et al. Background: Diagnosing scrub typhus clinically is difficult, hence laboratory tests play a very important role in diagnosis. As performing sophisticated laboratory tests in resource-limited settings is not feasible, accurate point-of-care testing (POCT) for scrub typhus diagnosis would be invaluable for patient diagnosis and management. Here we summarise the existing evidence on the accuracy of scrub typhus POCTs to inform clinical practitioners in resource-limited settings of their diagnostic value. Methodology/principal findings: Studies on POCTs which can be feasibly deployed in primary health care or outpatient settings were included. Thirty-one studies were identified through PubMed and manual searches of reference lists. The quality of the studies was assessed with the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). About half (n = 14/31) of the included studies were of moderate quality. Meta-analysis showed the pooled sensitivity and specificity of commercially available immunochromatographic tests (ICTs) were 66.0% (95% CI 0.37–0.86) and 92.0% (95% CI 0.83–0.97), respectively. There was a significant and high degree of heterogeneity between the studies (I2value = 97.48%, 95% CI 96.71–98.24 for sensitivity and I2value = 98.17%, 95% CI 97.67–98.67 for specificity). Significant heterogeneity was observed for total number of samples between studies (p = 0.01), study design (whether using case-control design or not, p = 0.01), blinding during index test interpretation (p = 0.02), and QUADAS-2 score (p = 0.01). Conclusions/significance: There was significant heterogeneity between the scrub typhus POCT diagnostic accuracy studies examined. Overall, the commercially available scrub typhus ICTs demonstrated better performance when ‘ruling in’ the diagnosis. There is a need for standardised methods and reporting of diagnostic accuracy to decrease between-study heterogeneity and increase comparability among study results, as well as development of an affordable and accurate antigen-based POCT to tackle the inherent weaknesses associated with serological testing.Publication Metadata only Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31-1 and the antiviral activity of scequinadoline A against dengue virus(2018-07-01) Dong Lan Wu; Hou Jin Li; Duncan R. Smith; Janejira Jaratsittisin; Xia Fu Kai Ti Xia-Ke-Er; Wen Zhe Ma; Yong Wei Guo; Jun Dong; Juan Shen; De Po Yang; Wen Jian Lan; Guangdong College of Pharmacy; Macau University of Science and Technology; Sun Yat-Sen University; Mahidol University© 2018 by the authors. In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of L-tryptophan and L-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.Publication Metadata only Effects of non-spatial pre-training on learning and memory impairment detection in the morris water maze(2018-02-01) Phanit Koomhin; Apsorn Sattayakhom; Sarawoot Palipoch; Chuchard Punsawad; Sompol Tapechum; Walailak University; Faculty of Medicine, Siriraj Hospital, Mahidol University© 2018, Walailak University. All rights reserved. One of the most popular learning and memory tests is the Morris water maze. The Morris water maze is a circular pool filled with water with a hidden platform under the water surface. The test is appropriate for rodents, especially rats and mice. The testing protocol comprises 2 parts that evaluate learning ability and memory retention. When animals are placed in the pool, they experience stress, which is the driving force for discovery of a strategy to leave the water. In the experiment, animals use environmental cues to find the location of the hidden platform in the pool. After consecutive training days, animals can more quickly locate the hidden platform. The last day of the task involves a memory test without the platform. It shows a limitation of the test in mild learning and memory deficit models such as 2-vessel occlusion. Differences between the normal and memory impairment models are expressed only in a narrow range. So, we tried to modify the original protocol for mild learning and memory impairment models. We used an albino rat strain for the experiment. A pre-training strategy of 3 days of swimming in the pool with a visible platform prior to the ordinary task was used. The results suggest that this pre-training strategy improved learning and memory in the rat model. When compared to normal rats and 2-vessel occlusion rats (a rat model for vascular dementia), those that participated in the pre-training strategy showed an increase in the percent difference of area under the curve for learning trials. In conclusion, the pre-training strategy increases ability to discriminate learning and memory impairment in the rat model, especially for the mild learning and memory deficit models.Publication Metadata only Nasalance scores in normal thai adults(2018-05-01) Sawittree Thana-Arak; Kalyanee Makarabhirom; Dechavudh Nityasuddhi; Chalermpong Chatdokmaiprai; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Huachiew Chalermprakiet University© 2018, Medical Association of Thailand. All rights reserved. Background: There is limited information exists on normative nasalance scores in normal Thai adults. Objective: To investigate the normative nasalance scores and how age and gender influence nasalance scores in normal Thai adults. Materials and Methods: After passing screening tests of communication disorders, 290 normal Thai adults were included as samples. Nasalance scores were obtained using nasometry when subjects read 3 Thai passages comprising Passage 1 which was the oral passage without nasal consonants, Passage 2 that was composed of a series of sentences containing 35% nasal consonants, and Passage 3 which was loaded the oro-nasal passage that included both oral and nasal consonants. Results: Mean nasalance scores for Passage 1, Passage 2, and Passage 3 were 16.69±5.21%, 51.64±4.98%, and 42.46±5.41%, respectively. Results did not show an explicit relationship between nasalance scores and age for all passages but revealed that females had significantly higher nasalance scores than males for all three reading passages at p<0.05. Conclusion: Present study determined that gender affected nasalance scores for Thai adults whereas age did not. Additional factors should be concerned and might be addressed through further research including dialect, hearing level, etc.Publication Metadata only Fractional ablative and nonablative radiofrequency for skin resurfacing and rejuvenation of Thai patients(2018-04-01) Wilai Thanasarnaksorn; Vorapot Siramangkhalanon; Diane Irvine Duncan; Inna Belenky; Poudre Valley Hospital; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Doctor Younger Clinic; Viora Inc.; Private Practice© 2017 Wiley Periodicals, Inc. Background: Fractional radiofrequency (RF) technology is often the preferable skin resurfacing treatment, especially among Asian patients. Second generation fractional RF technology has exclusive capability to produce separate biological responses (ablation, coagulation, or a combination of both) with 3 distinguished penetration depth programs. Aims: The aim of this study was to evaluate the efficacy and safety of a fractional RF handpiece such as this, on the Thai population. Methods: Fifty-five Thai patients were treated with a fractional RF handpiece. The clinical assessment included a pain score, satisfaction survey, physician assessment, a combined patient and physician's assessment of skin condition, and clinical photographic assessments. The wound healing response was evaluated according to 5-time points: immediately after applying a pulse, post 24 hours, post 7 days, post 1 month and post 8 weeks. Results: The obtained patient satisfaction score was “very satisfied” among 74% of the patients, post 3 sessions. Positive correlation was found between patient satisfaction and the physician's assessment. The skin condition assessment showed an increase from an average of 4.2 to 7.9. All treated symptoms improved after each treatment and the clinical outcome lasted at least up to 3–5 months. No significant adverse events were recorded. The in vivo prospective study showed a dose-related response in the deepness of the coagulation injury. In addition, there was evidence for a progressive healing process beginning shortly after exposure and completed within a week. Conclusions: This study clinically and histologically supports the efficacy of fractional RF handpiece in question with a high safety profile.Publication Metadata only Efficacy, Immunogenicity, and Safety of a 9-Valent Human Papillomavirus Vaccine: Subgroup Analysis of Participants from Asian Countries(2018-06-05) S. M. Garland; P. Pitisuttithum; H. Y.S. Ngan; C. H. Cho; C. Y. Lee; C. A. Chen; Y. C. Yang; T. Y. Chu; N. F. Twu; R. Samakoses; Y. Takeuchi; T. H. Cheung; S. C. Kim; L. M. Huang; B. G. Kim; Y. T. Kim; K. H. Kim; Y. S. Song; S. Lalwani; J. H. Kang; M. Sakamoto; H. S. Ryu; N. Bhatla; H. Yoshikawa; M. C. Ellison; S. R. Han; E. Moeller; S. Murata; M. Ritter; M. Sawata; C. Shields; A. Walia; G. Perez; A. Luxembourg; Ibaraki Prefectural Central Hospital; Bharati Vidyapeeth Medical College, Pune; National Taiwan University Hospital; Keimyung University (KU), College of Medicine; Chang Gung Memorial Hospital; Ewha Womans University School of Medicine; Mackay Memorial Hospital Taiwan; University of Melbourne; Buddhist Tzu-Chi General Hospital Taiwan; Jikei University; SungKyunKwan University, School of Medicine; Seoul National University; Veterans General Hospital-Taipei; Mahidol University; All India Institute of Medical Sciences, New Delhi; Merck & Co., Inc.; Phramongkutklao College of Medicine; The University of Hong Kong; University of Ulsan, College of Medicine; The Catholic University of Korea; Chinese University of Hong Kong; Ajou University; MSD K.K.; Fukui General Hospital© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. Background A 9-valent human papillomavirus-6/11/16/18/31/33/45/52/58 (9vHPV) vaccine extends coverage to 5 next most common oncogenic types (31/33/45/52/58) in cervical cancer versus quadrivalent HPV (qHPV) vaccine. We describe efficacy, immunogenicity, and safety in Asian participants (India, Hong Kong, South Korea, Japan, Taiwan, and Thailand) from 2 international studies: a randomized, double-blinded, qHPV vaccine-controlled efficacy study (young women aged 16-26 years; NCT00543543; Study 001); and an immunogenicity study (girls and boys aged 9-15 years; NCT00943722; Study 002). Methods Participants (N = 2519) were vaccinated at day 1 and months 2 and 6. Gynecological samples (Study 001 only) and serum were collected for HPV DNA and antibody assessments, respectively. Injection-site and systemic adverse events (AEs) were monitored. Data were analyzed by country and vaccination group. Results 9vHPV vaccine prevented HPV-31/33/45/52/58-related persistent infection with 90.4%-100% efficacy across included countries. At month 7, ≥97.9% of participants seroconverted for each HPV type. Injection-site AEs occurred in 77.7%-83.1% and 81.9%-87.5% of qHPV and 9vHPV vaccine recipients in Study 001, respectively, and 62.4%-85.7% of girls/boys in Study 002; most were mild to moderate. Conclusions The 9vHPV vaccine is efficacious, immunogenic, and well tolerated in Asian participants. Data support 9vHPV vaccination programs in Asia. Clinical Trials Registration NCT00543543; NCT00943722.Publication Metadata only Normative data of the interorbital distance in Thai population(2018-01-01) Chalermpong Chatdokmaiprai; Kidakorn Kiranantawat; Panuwat Lertsithichai; Patamintita Taeshineetanakul; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol UniversityCopyright © 2018 by Mutaz B. Habal, MD. The incidence of the patients with craniofacial anomalies was high in southeast-Asian countries, for example, fronto-ethmoidal encephalo-menigocele or craniosynostosis. These craniofacial anomalies usually involve orbits, so a surgical orbital reconstruction is always required. Various methods have been used in the past to indirectly analyze the craniofacial region. Plain skull radiography, anthropometry, and cephalometry provided the limited information of interorbital distance in terms of accuracy whereas the interorbital distance is crucial to be reconstructed, increasing or decreasing. The accurate normal interorbital distance which grows by age as other craniofacial structures is the important data in the part of interorbital and orbital reconstruction. To date, the normative data of the bony interorbital distance among Thai population have not been established. The purpose of this study is to provide normal values and the growth patterns of the bony interorbital distances and other dimensions of the orbit according to age among Thai population through the axial computed tomography. Comparisons can then be made between normal values and those for an individual patient or those for a group of patients, for example, those with front-ethmoidal meningoencephalocele, Crouzon, or Treacher–Collins syndrome, or among values for individual patients at different time intervals. A retrospective study of computed tomography (CT) scan series of 698 normal orbits from 349 skeletally normal subjects (202 men and 147 women) was enrolled. The age range of the patients was 0 to 21 years (mean, 10.2 years; SD, 5.8 years). A series of 12 measurements were obtained from the CT scans of each subject. All CT images were obtained from patients who underwent CT of the facial bone, brain, and orbits at the Department of Radiology of 3 big hospital in Bangkok–Ramathibodi, Samitivej Srinakarin, and Bangkok hospital–since 2010 to 2015. The normal measurement values in the orbital region through the CT images, as the normal periorbital growth curve, will help improving diagnostic accuracy, staging of reconstruction, precision of corrective surgery, and follow-up of the Thai patients with craniofacial abnormalities such as front-ethmoidal meningoencephalocele, hypertelorism. These data may also apply to the related population in the southeast-Asian countries.Publication Metadata only Transcutaneous oxygen tension and ankle-brachial index for predicting limb salvage outcomes in patients treated with drug-eluting stent for below-the-knee critical limb ischemia(2018-05-01) Nattawut Wongpraparut; Parichart Junpaparp; Chanean Ruangsetakit; Nongnuch Weerapakorn; Kamin Chinsakchai; Natee Sirinvaravong; Damras Tresukosol; Pramook Mutirangura; Rungtiwa Pongakasira; Albert Einstein Medical Center; Faculty of Medicine, Siriraj Hospital, Mahidol University© 2018, Medical Association of Thailand. All rights reserved. Background: Critical limb ischemia [CLI] is a serious cardiovascular condition that causes high morbidity and mortality. CLI can be identified by ankle pressure of less than 50 mmHg, toe pressure of less than 30 mmHg, or transcutaneous oxygen tension [TcPO 2 ] of less than 30 mmHg. Objective: To investigate the efficacy of TcPO 2 and ankle-brachial index [ABI] as predictors of limb salvage outcomes in patients treated with drug-eluting stent [DES] for below-the-knee CLI. Materials and Methods: This retrospective study was conducted in patients treated for CLI with below-the-knee [BTK] percutaneous transluminal angioplasty [PTA] with DES placement between January 2007 and June 2015 study period. The primary endpoints were pre-and post-procedural ABI and TcPO 2 . The secondary endpoints were limb salvage rate, time-to-major amputation, and ulcer healing. Results: Seventy-two patients (79 limbs) were included. Of those, 40 were men and 39 were women, and the mean age was 73.8±8.0 years. The median follow-up time was 349 days and the 1-year limb salvage rate was 95%. Complete wound healing at one year was observed in 76% of patients. Overall ABI was significantly improved from 0.70±0.17 to 0.89±0.26 (p<0.001). In isolated below-the-knee DES patients, ABI was significantly improved from 0.74±0.18 to 0.99±0.25 (p = 0.019), and TcPO 2 was significantly improved from 17.50±9.62 to 35.50±11.84 mmHg (p = 0.035). Conclusion: Long-term outcome of DES placement at BTK level was associated with high limb salvage rate and wound healing, as evidenced by increased ABI and TcPO 2 .Publication Metadata only Comparison of prevalence and risk factors associated with cognitive impairment between rural and urban elderly in Thailand(2018-03-01) Sariyamon Tiraphat; Wichai Aekplakorn; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University© 2018, Medical Association of Thailand. All rights reserved. Objective: To examine the prevalence and risk factors of cognitive impairment in Thai older population living in urban and rural across the country. Materials and Methods: The present study used data from the fourth Thai National Health Examination Survey [NHES IV]. The study population was 6,633 Thai elderly aged 60 years and older living in urban and rural area. Chi-square and multiple logistic regression analysis were applied to investigate prevalence and predictors of being cognitive impairment among the elderly. Results: Prevalence of cognitive impairment among older Thai was 10.2%, with 11.7% and 8.7% in rural and urban, respectively. Significant predictors of the impairment among Thai elderly in both rural and urban included living region, gender, age, education, and active leisure. In addition, perceived poor health status was a significant predictor of the impairment in urban elderly, whereas poor economic condition was a significant predictor of the impairment in rural elderly. Conclusion: The present study has confirmed that education and active leisure are protective factors against cognitive impairment among Thai elderly. However, poor economic condition and perceived poor health status are the risk factors associated with cognitive decline in rural and urban elderly, respectively.Publication Metadata only The Synergy of Endotoxin and (1→3)-β-D-Glucan, from Gut Translocation, Worsens Sepsis Severity in a Lupus Model of Fc Gamma Receptor IIb-Deficient Mice(2018-06-01) Jiraphorn Issara-Amphorn; Saowapha Surawut; Navaporn Worasilchai; Arthid Thim-Uam; Malcolm Finkelman; Ariya Chindamporn; Tanapat Palaga; Nattiya Hirankarn; Prapaporn Pisitkun; Asada Leelahavanichkul; Chulalongkorn University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Faculty of Medicine, Thammasat University; Interdisciplinary and International Program; Center of Excellence in Immunology and Immune-mediated Diseases; Associates of Cape Cod, Inc.; Faculty of Graduate Studies© 2018 S. Karger AG, Basel. We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. Spontaneous gut leakage, determined by (i) the presence of FITC-dextran, (ii) elevated serum endotoxin, and (iii) elevated serum (1→3)-β-D-glucan (BG), was demonstrated in symptomatic lupus but not in the asymptomatic group. In parallel, spontaneous gut leakage, detected by elevated serum BG without fungal infection, was demonstrated in patients with active lupus nephritis. Gut leakage induced by dextran sulfate solution (DSS) or endotoxin administration together with BG or endotoxin alone, but not BG alone, enhanced the severity of cecal ligation and puncture (CLP) sepsis more prominently in 8-week-old FcGRIIb-/- mice. Additionally, the bone marrow-derived macrophages of FcGRIIb-/- mice produced higher cytokine levels when coexposed to endotoxin and BG, when compared to wild-type mice. In summary, spontaneous gut leakage was demonstrated in symptomatic FcGRIIb-/- mice and the induction of gut permeability worsened sepsis severity. Gut translocation of endotoxin and BG had a minor effect on wild-type mice, but the synergistic effect of BG and endotoxin was prominent in FcGRIIb-/- mice. The data suggest that therapeutic strategies addressing gut leakage may be of interest in sepsis conditions in patients with lupus.