Publication: Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
Issued Date
2002-12-01
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ISSN
13835769
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2-s2.0-0036882321
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology International. Vol.51, No.4 (2002), 361-366
Suggested Citation
Kazuya Omi, Jun Ohashi, Jintana Patarapotikul, Hathairad Hananantachai, Izumi Naka, Sornchai Looareesuwan, Katsushi Tokunaga Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitology International. Vol.51, No.4 (2002), 361-366. doi:10.1016/S1383-5769(02)00040-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20179
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Title
Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
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Abstract
Human FcγRIIA and FcγRIIIB exhibit genetic polymorphisms, FcγRIIA-131H/R and FcγRIIIB-NA1/NA2, coding for different capacities for IgG binding and phagocytosis. Recently, FcγRIIA-131R was reported to be associated with protection against high-density Plasmodium falciparum infection in Kenya. Furthermore, FcγRIIIB-NA1/NA2 polymorphism was shown to influence FcγRIIA function in an allele-specific manner. In this study, we examined a possible association of FcγRIIA-131H/R and FcγRIIIB-NA1/NA2 polymorphisms with malaria severity in 107 cerebral malaria patients, 157 non-cerebral severe malaria patients, and 202 mild malaria controls living in northwest Thailand. This study reveals that, with the FcγRIIIB-NA2 allele, the FcγRIIA-131H/H genotype is associated with susceptibility to cerebral malaria (OR 1.85, 95% CI 1.14-3.01; P=0.012), although these polymorphisms are not individually involved in the disease severity. Our results suggest that FcγRIIA-131H/R and FcγRIIIB-NA1/NA2 polymorphisms have an interactive effect on host defense against malaria infection. © 2002 Elsevier Science Ireland Ltd. All rights reserved.