Publication: Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis
| dc.contributor.author | Sanya Sureram | en_US |
| dc.contributor.author | Sarath P D Senadeera | en_US |
| dc.contributor.author | Poonpilas Hongmanee | en_US |
| dc.contributor.author | Chulabhorn Mahidol | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.contributor.other | Chulabhorn Graduate Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | South Carolina Commission on Higher Education | en_US |
| dc.date.accessioned | 2018-06-11T04:37:44Z | |
| dc.date.available | 2018-06-11T04:37:44Z | |
| dc.date.issued | 2012-04-15 | en_US |
| dc.description.abstract | Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905 | en_US |
| dc.identifier.doi | 10.1016/j.bmcl.2012.02.053 | en_US |
| dc.identifier.issn | 14643405 | en_US |
| dc.identifier.issn | 0960894X | en_US |
| dc.identifier.other | 2-s2.0-84859441948 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/13759 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859441948&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859441948&origin=inward | en_US |
