Publication: Translating Knowledge About the Immune Microenvironment of Gastrointestinal Stromal Tumors into Effective Clinical Strategies
Issued Date
2021-01-01
Resource Type
ISSN
15346277
15272729
15272729
Other identifier(s)
2-s2.0-85099427181
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Treatment Options in Oncology. Vol.22, No.1 (2021)
Suggested Citation
Jomjit Chantharasamee, Jacob J. Adashek, Karlton Wong, Mark A. Eckardt, Bartosz Chmielowski, Sarah Dry, Fritz C. Eilber, Arun S. Singh Translating Knowledge About the Immune Microenvironment of Gastrointestinal Stromal Tumors into Effective Clinical Strategies. Current Treatment Options in Oncology. Vol.22, No.1 (2021). doi:10.1007/s11864-020-00806-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78853
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Title
Translating Knowledge About the Immune Microenvironment of Gastrointestinal Stromal Tumors into Effective Clinical Strategies
Abstract
The role of targeted therapy is firmly established for gastrointestinal stromal tumors (GISTs); other modalities for targeting this disease are necessary for recurrent and refractory disease. There are several lines of evidence pointing to an active role of the immune system in GIST. Preclinical and clinical studies revealed that the most common type of immune cell infiltration in GISTs is tumor-associated macrophages (TAMs). The mechanism of how TAMs sculpt the tumor microenvironment in GIST is not clear, but it seems that the presence of immunosuppressive regulatory T cells (Tregs) is correlated with the number of TAMs, thus linking macrophages to immunosuppression. CD3+ T cells and NK infiltrates are found in the GIST microenvironment and carry some prognostic value. In early clinical trials, there is evidence for an active role for immunotherapy in treating GIST patients. Moreover, preclinical evidence has indicated that combining TKIs with checkpoint blockers may be synergistic in murine GIST models. Overall, there is substantial preclinical and clinical evidence to support a role for immunoregulation in GIST and further studies will be important for the development of immunotherapies for GIST.