Publication: Antilipopolysaccharide II: An antibody protective against fatal melioidosis
Issued Date
1999-01-01
Resource Type
ISSN
10584838
DOI
Other identifier(s)
2-s2.0-0033509738
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Infectious Diseases. Vol.29, No.4 (1999), 813-818
Suggested Citation
Chadarat Charuchaimontri, Yupin Suputtamongkol, Churairat Nilakul, Wipada Chaowagul, Ploenchan Chetchotisakd, Nimit Lertpatanasuwun, Sunanta Intaranongpai, Paul J. Brett, Donald E. Woods Antilipopolysaccharide II: An antibody protective against fatal melioidosis. Clinical Infectious Diseases. Vol.29, No.4 (1999), 813-818. doi:10.1086/520441 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25766
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Title
Antilipopolysaccharide II: An antibody protective against fatal melioidosis
Abstract
This was a study of IgG antibody responses to two S-type lipopolysaccharides (LPS I and LPS II) and flagellin of Burkholderia pseudomallei in patients with melioidosis. The specificity of these antibodies was 91.7%, 90.3%, and 93.8%, respectively, when compared to responses in a population where the organism is not endemic. Only the level of antibody to LPS II (anti-LPS II) was significantly higher in patients who survived than in those who died, as well as in patients with nonsepticemic vs. septicemic melioidosis. Results of logistic regression analysis, controlled for confounding factors such as duration of illness before treatment and bacteremic status, confirmed that a high level of anti-LPS II was a significant factor protective against fatal melioidosis. Thus, LPS II of B. pseudomallei would be a potentially useful component of a vaccine developed against fatal melioidosis. Further studies are in progress to determine the level of this antibody among those with asymptomatic infection in areas where melioidosis is endemic.