Publication: Effects of handwriting exercise on functional outcome in Parkinson disease: A randomized controlled trial
Issued Date
2019-01-01
Resource Type
ISSN
15322653
09675868
09675868
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2-s2.0-85071836609
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Neuroscience. (2019)
Suggested Citation
Nisa Vorasoot, Pichet Termsarasab, Kunlawat Thadanipon, Teeratorn Pulkes Effects of handwriting exercise on functional outcome in Parkinson disease: A randomized controlled trial. Journal of Clinical Neuroscience. (2019). doi:10.1016/j.jocn.2019.08.119 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52174
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Title
Effects of handwriting exercise on functional outcome in Parkinson disease: A randomized controlled trial
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Abstract
© 2019 Elsevier Ltd Parkinson disease (PD) patients frequently experience micrographia and difficulty writing, which could potentially impact their quality of life. This study aimed to determine whether handwriting exercise could improve fine manual motor function in PD. The study was a randomized controlled trial assessing the efficacy of a 4-week handwriting exercise using a newly developed handwriting practice book. The primary endpoint was an improvement in the time used to complete the handwriting test. Secondary endpoints were accuracy of the writing performance, patient's subjective rating scale of their handwriting and a UPDRS part III motor examination. Of a total of 46 subjects, 23 were randomly assigned to the handwriting exercise group. After 4 weeks, the mean time used to complete the test was significantly lower in the exercise group, compared to the control group (143.43 ± 34.02 vs. 175 ± 48.88 s, p = 0.015). Mean time used to complete the handwriting test decreased from the baseline by 16.16% in the exercise group, but increased by 3.63% in the control group (p < 0.001). Significant improvements were also observed by assessing the subjective rating scale and the UPDRS part III scores. The 4-week handwriting exercise using the studied handwriting practice book appears to promote an improvement in writing speed and motor function of hands. The optimal duration and frequency of the exercise, the quantity and characteristic of the letters in the handwriting practice book, and the benefits of the exercise in other languages merit further studies.