Japanese Journal of Pharmacology. Vol.78, No.3 (1998), 395-398
Suggested Citation
Penchom Peungvicha, Suwan S. Thirawarapan, Hiroshi Watanabe Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root. Japanese Journal of Pharmacology. Vol.78, No.3 (1998), 395-398. doi:10.1254/jjp.78.395 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18630
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Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root
We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.
