Publication: Paliperidone palmitate-induced facial angioedema: A case report
Issued Date
2020-10-26
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ISSN
23078960
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2-s2.0-85095768571
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Mahidol University
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SCOPUS
Bibliographic Citation
World Journal of Clinical Cases. Vol.8, No.20 (2020), 4876-4882
Suggested Citation
Maytinee Srifuengfung, Thanisorn Sukakul, Chanika Liangcheep, Natee Viravan Paliperidone palmitate-induced facial angioedema: A case report. World Journal of Clinical Cases. Vol.8, No.20 (2020), 4876-4882. doi:10.12998/wjcc.v8.i20.4876 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60038
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Title
Paliperidone palmitate-induced facial angioedema: A case report
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Abstract
© 2020 Elsevier Ltd BACKGROUND: Paliperidone palmitate is a once-monthly injectable, atypical antipsychotic. To our knowledge, there has been only one report of paliperidone palmitate-induced angioedema presenting with acute laryngeal edema with subsequent respiratory arrest. Here, we present a case report of paliperidone palmitate-induced angioedema with a relatively mild clinical presentation compared with the previously reported case, and the patient's condition was not complicated by life-threatening anaphylaxis. CASE SUMMARY: A 79-year-old female, who had a major neurocognitive disorder due to Alzheimer's disease with behavioral disturbances. Paliperidone palmitate was off- label used to control her aggression, irritability, and psychosis. After induction doses (150 mg and 100 mg intramuscularly, given 1 wk apart), she developed intermittent swelling of the face, eyelids, and lips on day 17 after the initial dose, and the edema was explicitly seen on day 20. The diagnosis was paliperidone palmitate-induced angioedema. The monthly injection dose was discontinued on day 33 after the initial dose. The angioedema was subsequently alleviated, and it had completely resolved by day 40 after the initial dose. CONCLUSION: Paliperidone palmitate-induced angioedema is a rare condition and can present with a mild, intermittent facial edema, which may be overlooked in clinical practice.