Scopus 2020
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Publication Metadata only JITBot: An Explainable Just-In-Time Defect Prediction Bot(2020-09-01) Chaiyakarn Khanan; Worawit Luewichana; Krissakorn Pruktharathikoon; Jirayus Jiarpakdee; Chakkrit Tantithamthavorn; Morakot Choetkiertikul; Chaiyong Ragkhitwetsagul; Thanwadee Sunetnanta; Monash University; Mahidol University© 2020 ACM. Just-In-Time (JIT) defect prediction is a classification model that is trained using historical data to predict bug-introducing changes. However, recent studies raised concerns related to the explain-ability of the predictions of many software analytics applications (i.e., practitioners do not understand why commits are risky and how to improve them). In addition, the adoption of Just-In-Time defect prediction is still limited due to a lack of integration into CI/CD pipelines and modern software development platforms (e.g., GitHub). In this paper, we present an explainable Just-In-Time defect prediction framework to automatically generate feedback to developers by providing the riskiness of each commit, explaining why such commit is risky, and suggesting risk mitigation plans. The proposed framework is integrated into the GitHub CI/CD pipeline as a GitHub application to continuously monitor and analyse a stream of commits in many GitHub repositories. Finally, we discuss the usage scenarios and their implications to practitioners. The VDO demonstration is available at https://jitbot-tool.github.io/.Publication Metadata only Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications(2020-12-16) Saravut Satitsri; Chatchai Muanprasat; Mahidol UniversityChitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.Publication Metadata only The experiential learning unit for promoting students’ understanding of vapor pressure and related concepts(2020-01-01) Siwa Mahardthai; Supan Yodyingyong; Namkang Sriwattanarothai; Piyachat Jittam; Mahidol University© 2020, Springer Nature Singapore Pte Ltd. Vapor pressure is a difficult concept for high school students because it requires understanding at the microscopic level. To better understand the concept, students should clearly understand some prerequisite concepts, such as evaporation, condensation, and pressure. Therefore, this research aims to develop Kolb’s experiential learning activities for providing experience before extending to learn the vapor pressure concept through online resources. The learning unit consists of two main activities that are 1) observing scientific phenomena aims at helping students to gain experience of the concepts, and 2) color manipulatives designing to help students to understand the concepts at the microscopic level. The learning unit had been implemented with grade ten students. The conceptual test and interview had been used to assess student understanding. Results show that some students still have learning difficulties related to vapor pressure and related concepts. They had difficulty in explaining the concepts at the molecular explanation and confused some technical terms. The online resources have been discussed for suggesting a suitable pathway to each group of students.Publication Metadata only Circular economy approach for wastewater treatment farming in Bangpakong River basin(2020-12-09) N. Surinkul; S. Threedeach; W. Chiemchaisri; C. Chiemchaisri; Kasetsart University; Mahidol University; Suan Dusit University© 2020 Published under licence by IOP Publishing Ltd. Bangpakong River is one of river basins that faced the pollution problem in Thailand. This river is located in the downstream of central pain of Thailand and flows into the sea at the gulf of Thailand. Water quality problems in the last decade of this river basin are appeared from the low water quality index with evidences such as dead of fish, black color of water, low Dissolved Oxygen (DO) concentrations, high organics and nutrients concentrations, high contaminated of coliform bacteria. All wastewater is controlled by the environmental law. Only wastewater from agriculture part is not yet properly managed. The objective of this study was to quantify the mass and material flows in agricultural farms such as pig, fish and prawn farms. Circular economy concept as reuse of wastewater in agricultural farms was approached in scenario. Surveys, questionnaires and water samplings were taken for farms. Information and mass flows within the farms were analyzed. This study found that the main source of pollution from these farms mostly resulted from the effluent of wastewater in term of Biological Oxygen Demand (BOD) and Total Nitrogen (TN) loads, were discharged into the environment. The hot spot areas were canals which flow to the river. Mass flows in pig farm revealed that BOD and TN loads to the environment were 90, and 120 tons/year. In which, calculated thresholds were 30 and 60 tons/year for BOD and TN. Similar results also found from aquaculture farms which contributes BOD and TN loads of 187 and 77 tons/year for fish farms and 156 and 84 tons for prawn farms. In this study, calculated reuse as circular economy approach about 50% of farm wastewater to agricultural field could provide the key role of BOD and TN reduction to the environment, and meeting the threshold level.Publication Metadata only Sustainable development: Gender equality as corporate social responsibility by mining companies(2020-01-01) Nattavud Pimpa; Mahidol UniversityCopyright © 2020 Inderscience Enterprises Ltd. The gendered impacts of mining industry on women is critical for mining companies. A key challenge for the management of sustainable development programs for gender equality is the need to develop sophisticated approaches that work at the local and international levels. In this paper, the researcher investigates the impact of CSR programs on women through the perceptions and life experiences of female workers and various members of the mining community in La PDRs. The results show that CSR programs on women employment, social roles of women in the organisation, health promotion, and vocational training can influence the likelihood of sustainable development by mining companies. However, the extent to which mining companies can be considered focus and accountable development agents remains limited due to the instrumental nature of development-oriented CSR programs.Publication Metadata only Expression of anthocyanin biosynthetic genes in ornamental bananas(2020-12-08) P. Kongsawadworakul; P. Vattanatam; W. Inta; U. Viboonjun; S. C. Swangpol; Mahidol University© 2020 International Society for Horticultural Science. All rights reserved. One of the attractive tropical plants is ornamental bananas with colorful male inflorescence bracts. Anthocyanin components and combination within these bracts relate to the color variations that occur in the banana family, Musaceae. Anthocyanin biosynthesis of several pigments and genes has already been studied. However, the underlining genetic background which causes color differences has not been explained. In our study, to investigate the molecular genetic background of the color variations in bracts of the bananas, anthocyanin biosynthetic pathways in uncommon yellow and pale purple bract taxa were compared to that of other species with orange and red-purple bracts. Anthocyanin content and expression analysis of dihydroflavonol 4-reductase (DFR) and leucoanthocyanidin dioxygenase (LDOX) genes were analyzed. The results showed that the expression level of DFR and LDOX genes was almost absent in the orange-and-red-purple colored-deficient taxa, i.e., the yellow bract Musa rubra var. siamensis and the green bract Ensete glaucum. Thus, the results suggested these two genes positively are factors related to anthocyanin accumulation in the banana bracts.Publication Metadata only Illegal logging listeners using IoT networks(2020-11-16) Ananta Srisuphab; Nopparat Kaakkurivaara; Piyanuch Silapachote; Kitipong Tangkit; Ponthep Meunpong; Thanwadee Sunetnanta; Kasetsart University; Mahidol University© 2020 IEEE. Protecting and increasing worldwide green space have been an international effort. Individuals and organizations are encouraged to plant urban trees and to get involved in many reforestation and restoration projects. Offsetting these much needed plans to save the forests is illegal logging. Trees that have grown for many years, some are protected resources inside restricted areas, are felled and the wood is smuggled. Watching for these illegal activities is very difficult and also very dangerous. It is quite impossible for rangers to patrol every entry and exit point of forests that cover thousands of squared kilometers. Applying Internet of Things technology to ecological forestry, we are proposing integrating sound acquisition networks and acoustic signal analyzers to enhance the robustness of an already successful camera-based surveillance solution that is also equipped with a global positioning system tracker. Our listener devices record sounds of the forest and periodically send it to a cloud storage over cellular networks. The device is affordable, the system is small and portable, and the network is flexibly extensible. From the data, acoustic features are extracted and visualized. The Mel-frequency cepstral coefficients of the signals have exhibited promising distinctiveness for detection of illegal chainsaw activities in the wild.Publication Metadata only Carbon monoxide-releasing molecules inhibit the cystic fibrosis transmembrane conductance regulator Cl-channel(2020-12-18) Mayuree Rodrat; Walailak Jantarajit; Demi R.S. Ng; Bartholomew S.J. Harvey; Jia Liu; William J. Wilkinson; Narattaphol Charoenphandhu; David N. Sheppard; College of Biomedical and Life Sciences; University of Bristol; Mahidol University; Academy of Science© 2020 the American Physiological Society. The gasotransmitter carbon monoxide (CO) regulates fluid and electrolyte movements across epithelial tissues. However, its action on anion channels is incompletely understood. Here, we investigate the direct action of CO on the cystic fibrosis transmembrane conductance regulator (CFTR) by applying COreleasing molecules (CO-RMs) to the intracellular side of excised inside-out membrane patches from cells heterologously expressing wild-type human CFTR. Addition of increasing concentrations of tricarbonyldichlororuthenium(II) dimer (CORM-2) (1-300 μM) inhibited CFTR channel activity, whereas the control RuCl3 (100 μM) was without effect. CORM-2 predominantly inhibited CFTR by decreasing the frequency of channel openings and, hence, open probability (Po). But, it also reduced current flow through open channels with very fast kinetics, particularly at elevated concentrations. By contrast, the chemically distinct CO-releasing molecule CORM-3 inhibited CFTR by decreasing Po without altering current flow through open channels. Neither depolarizing the membrane voltage nor raising the ATP concentration on the intracellular side of the membrane affected CFTR inhibition by CORM-2. Interestingly, CFTR inhibition by CORM-2, but not by CFTRinh-172, was prevented by prior enhancement of channel activity by the clinically approved CFTR potentiator ivacaftor. Similarly, when added after CORM-2, ivacaftor completely relieved CFTR inhibition. In conclusion, CORM-2 has complex effects on wild-type human CFTR consistent with allosteric inhibition and openchannel blockade. Inhibition of CFTR by CO-releasing molecules suggests that CO regulates CFTR activity and that the gasotransmitter has tissue-specific effects on epithelial ion transport. The action of ivacaftor on CFTR Cl - channels inhibited by CO potentially expands the drug's clinical utility.Publication Metadata only The Efficacy of Two Different Concentrations of Local Anaesthetic on Pain in Mandibular Third Molar Surgery(2020-01-01) Thippayarat Piernon; Basel Mahardawi; Kumar KC; Chakorn Vorakulpipat; Bishwa Prakash Bhattarai; Natthamet Wongsirichat; Walailak University; Mahidol Universityhttp://aos.usm.my/ © Penerbit Universiti Sains Malaysia. 2020 Mepivacaine is a common local anaesthetic used with claims of a high safety profile. There are two commercial types, 2% mepivacaine with vasoconstrictor and 3% without vasoconstrictor. There are many suggestions regarding the usage of plain 3% without vasoconstrictor for systemic medical problems, however, there have not been any previous studies to confirm this necessity in impacted lower third molar surgery (ILTMS). This study aims to evaluate the anaesthetic efficiency and the effect on the patient of 2% and 3% mepivacaine, adding vasoconstrictor to the 3% mepivacaine. This crossover study comprised of 24 patients with bilateral, symmetrically positioned, impacted lower third molars. Patients received either 2% or 3% mepivacaine for the inferior alveolar nerve block (IANB). Onset and duration of anaesthesia, and haemodynamic considerations were analysed as primary outcomes. Furthermore, pain, duration of postoperative anaesthesia and pulp vitality were analysed as secondary outcomes. Different concentrations of mepivacaine showed similar anaesthetic onset time (p > 0.05). There was no statistically significant difference regarding the duration of anaesthesia, as well as the postoperative analgesia (p > 0.05). The two concentrations did not lead to any haemodynamic changes or complications during ILTMS. Thus, adding the vasoconstrictor to mepivacaine 3% did not cause any adverse effects on the patients intra or postoperatively. Therefore, it is possible for dentists to use only 2% mepivacaine with vasoconstrictor for IANB effectively and safely when the case necessitates the need for a vasoconstrictor, or in other words, longer duration of haemostasis.Publication Metadata only The efficacy of dental sealant used with bonding agent on occlusal caries (ICDAS 2-4): A 24-month randomized clinical trial(2020-01-01) Pornpailin Kasemkhun; Siriruk Nakornchai; Araya Phonghanyudh; Natchalee Srimaneekarn; Mahidol University© 2020 BSPD, IAPD and John Wiley & Sons Ltd Background: Bonding before sealant application enhances retention on saliva-contaminated sound teeth; however, there are few studies of bonding's efficacy on sealant retention on occlusal caries. Aim: To evaluate a bonding agent's efficacy on sealant retention on occlusal caries and caries transition. Design: One hundred twenty pairs of first permanent molars with occlusal caries (ICDAS 2-4) from 98 children aged 7.3-9.9 years were included. One molar was randomly selected to use bonding (Adper™ Single Bond 2, 3M ESPE) applied before sealant application (Helioseal®clear, Ivoclar Vivadent). Bonding was not used on the contralateral tooth. Retention was determined using Simonsen's criteria; caries transition was evaluated using ICDAS scores, DIAGNOdent values, and bitewings at baseline, 6, 12, and 24 months. Data were analyzed with McNemar's and Fisher's exact tests. Results: Bonding agent use significantly increased sealant retention rates (P <.001). Bonded (B) sealants had a higher retention rate (83.3%) than non-bonded (NB) sealants (53.7%). The difference in the caries-transition rate was not significant between the groups (P >.05). Three teeth (1.4%; NB:B = 2:1) were restored due to radiographic dentin-caries progression. Conclusions: Using a bonding agent before applying sealant on permanent molar occlusal caries (ICDAS 2-4) significantly enhanced sealant retention. Caries progression was rarely detected at the 24-month follow-up.Publication Metadata only Whole-genome sequence analysis and comparisons between drug-resistance mutations and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB(2020-12-01) Ditthawat Nonghanphithak; Orawee Kaewprasert; Pratchakan Chaiyachat; Wipa Reechaipichitkul; Angkana Chaiprasert; Kiatichai Faksri; Khon Kaen University; Faculty of Medicine, Siriraj Hospital, Mahidol University© 2020 Nonghanphithak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Drug resistance (DR) remains a major challenge for tuberculosis (TB) control. Whole-genome sequencing (WGS) provides the highest genetic resolution for genotypic drug-susceptibility tests (DST). We compared DST profiles of 60 Mycobacterium tuberculosis isolates which were drug resistant according to agar proportion tests (one poly DR-TB, 34 multidrug-resistant TB and 25 extensively drug-resistant TB). We additionally performed minimum inhibitory concentration (MIC) tests using Sensititre MYCOTBI plates (MYCOTB) and a WGS-based DST. Agreement between WGS-based DST and MYCOTB was high for all drugs except ethambutol (65%) and ethionamide (62%). Isolates harboring the -15 c/t inhA promoter mutation had a significantly lower MIC for isoniazid than did isolates with the katG Ser315Thr mutation (p < 0.001). Similar patterns were seen for ethambutol (embB Gly406Asp vs. embB Met306Ile), streptomycin (gid Gly73Ala vs. rpsL Lys43Arg), moxifloxacin (gyrA Ala90Val vs. gyrA Asp94Gly) and rifabutin (rpoB Asp435Phe/Tyr/Val vs. rpoB Ser450Leu). For genotypic heteroresistance, isolates with lower proportion of mapped read tended to has lower MIC of anti-TB drugs than those with higher proportion. These results emphasize the high applicability of WGS for determination of DR-TB and the association of particular mutations with MIC levels.Publication Metadata only Techno-economic assessment of a biomass torrefaction plant for pelletized agro-residues with flue gas as a main heat source(2020-12-01) Thossaporn Onsree; Chawannat Jaroenkhasemmeesuk; Nakorn Tippayawong; Mahidol University; Chiang Mai University© 2020 The Authors Torrefaction combined with densification for upgrading biomass to torrefied biomass pellets is increasingly of great interest since torrefied biomass pellets are considered as a major renewable energy source. Especially in the application of co-firing with coal, torrefaction may be easily integrated into an existing co-firing power plant, whose flue gases from the power plant could be used to torrefy biomass pellets. This could also help to improve the overall carbon efficiency of the power plant and reduce emissions of greenhouse gases. In the present work, a torrefaction plant for corn residue pellets to produce torrefied solid fuels using flue gases as a main heat source was simulated in Aspen Plus® software. Torrefaction module was successfully modelled by an RYield reactor, which was programmed with the two-steps-in-series kinetic for the decomposition of biomass pellets as well as the volatile formation for by-products. The model can, therefore, provide the distribution and yield of both torrefied biomass pellets and volatile by-products. From the validation, the simulation results appeared to show good agreement with available experimental data in the literature. At the suggested conditions of 260 °C wet flue gas and 20 min residence time, thermal energy of 460 J/g and 380 J/g were required for the drying and the torrefaction modules, respectively. At these conditions, the performance of the whole process was found to be almost 95%. This plant produced 75% w/w torrefied biomass pellets yield with HHV of 21.9 MJ/kg. The by-products mainly included 10.7% w/w water, 7.4% w/w CO2, and 1.7% w/w CO. Our findings provide a feasible outlook for integrating a torrefaction process of biomass pellets into a co-firing power plant, utilizing a realistic heat of waste flue gases for the process.Publication Metadata only Mobile learning technology in STEM education: A systematic review from 2010 to 2019(2020-11-23) Wacharaporn Khaokhajorn; Prapawan Thongsri; Patcharin Panjaburee; Niwat Srisawasdi; Sakon Nakhon Rajabhat University; Khon Kaen University; Mahidol UniversityCopyright © 2020 Asia-Pacific Society for Computers in Education. Mobile technology could support students' learning in anytime and anywhere. It led to mobile learning principle, which has been recognized as pedagogy to support the learning of Science, Technology, Engineering, and Mathematics (STEM). Recently, there is less systematic analysis to reveal trend of mobile learning in STEM education. This paper conducted a metareview of the studies published in academic journals, indexed by Scopus, from 2010 to 2019 to analyze years, nationalities, and subject areas emphasizing the pedagogy and technology of mobile learning in STEM education. The results revealed that the application of mobile learning technology in STEM disciplines have been increased in the past decade. In addition, the review articles reported subject areas in social science has the highest number of using mobile technology in STEM learning. The findings of this study encourage more educational research in the area of mobile learning technology in STEM education.Publication Metadata only Exploring of paritaprevir and glecaprevir resistance due to A156T mutation of HCV NS3/4A protease: molecular dynamics simulation study(2020-01-01) Thitiya Boonma; Bodee Nutho; Nitchakan Darai; Thanyada Rungrotmongkol; Nadtanet Nunthaboot; Chulalongkorn University; Mahidol University; Mahasarakham University© 2021 Informa UK Limited, trading as Taylor & Francis Group. Hepatitis C virus (HCV) NS3/4A serine protease is a promising drug target for the discovery of anti-HCV drugs. However, its amino acid mutations, particularly A156T, commonly lead to rapid emergence of drug resistance. Paritaprevir and glecaprevir, the newly FDA-approved HCV drugs, exhibit distinct resistance profiles against the A156T mutation of HCV NS3/4A serine protease. To illustrate their different molecular resistance mechanisms, molecular dynamics simulations and binding free energy calculations were carried out on the two compounds complexed with both wild-type (WT) and A156T variants of HCV NS3/4A protease. QM/MM-GBSA-based binding free energy calculations revealed that the binding affinities of paritaprevir and glecaprevir towards A156T NS3/4A were significantly reduced by ∼4 kcal/mol with respect to their WT complexes, which were in line with the experimental resistance folds. Moreover, the relatively weak intermolecular interactions with amino acids such as H57, R155, and T156 of NS3 protein, the steric effect and the destabilized protein binding surface, which is caused by the loss of salt bridge between R123 and D168, are the main contributions for the higher fold-loss in potency of glecaprevir due to A156T mutation. An insight into the difference of molecular mechanism of drug resistance against the A156T substitution among the two classes of serine protease inhibitors could be useful for further optimization of new generation HCV NS3/4A inhibitors with enhanced inhibitory potency. Communicated by Ramaswamy H. Sarma.Publication Metadata only Novel SOX10 Mutations in Waardenburg Syndrome: Functional Characterization and Genotype-Phenotype Analysis(2020-12-09) Supranee Thongpradit; Natini Jinawath; Asif Javed; Laran T. Jensen; Issarapa Chunsuwan; Kitiwan Rojnueangnit; Thipwimol Tim-Aroon; Krisna Lertsukprasert; Meng Shin Shiao; Nongnuch Sirachainan; Duangrurdee Wattanasirichaigoon; A-Star, Genome Institute of Singapore; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University; Thammasat University; The University of Hong Kong© Copyright © 2020 Thongpradit, Jinawath, Javed, Jensen, Chunsuwan, Rojnueangnit, Tim-Aroon, Lertsukprasert, Shiao, Sirachainan and Wattanasirichaigoon. Waardenburg syndrome (WS) is a prevalent hearing loss syndrome, concomitant with focal skin pigmentation abnormalities, blue iris, and other abnormalities of neural crest-derived cells, including Hirschsprung’s disease. WS is clinically and genetically heterogeneous and it is classified into four major types WS type I, II, III, and IV (WS1, WS2, WS3, and WS4). WS1 and WS3 have the presence of dystopia canthorum, while WS3 also has upper limb anomalies. WS2 and WS4 do not have the dystopia canthorum, but the presence of Hirschsprung’s disease indicates WS4. There is a more severe subtype of WS4 with peripheral nerve and/or central nervous system involvement, namely peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, WS, and Hirschsprung’s disease or PCW/PCWH. We characterized the genetic defects underlying WS2, WS4, and the WS4-PCW/PCWH) using Sanger and whole-exome sequencing and cytogenomic microarray in seven patients from six unrelated families, including two with WS2 and five with WS4. We also performed multiple functional studies and analyzed genotype–phenotype correlations. The cohort included a relatively high frequency (80%) of individuals with neurological variants of WS4. Six novel SOX10 mutations were identified, including c.89C > A (p.Ser30∗), c.207_8 delCG (p.Cys71Hisfs∗62), c.479T > C (p.Leu160Pro), c.1379 delA (p.Tyr460Leufs∗42), c.425G > C (p.Trp142Ser), and a 20-nucleotide insertion, c.1155_1174dupGCCCCACTATGGCTCAGCCT (p.Phe392Cysfs∗117). All pathogenic variants were de novo. The results of reporter assays, western blotting, immunofluorescence, and molecular modeling supported the deleterious effects of the identified mutations and their correlations with phenotypic severity. The prediction of genotype–phenotype correlation and functional pathology, and dominant negative effect vs. haploinsufficiency in SOX10-related WS were influenced not only by site (first two vs. last coding exons) and type of mutation (missense vs. truncation/frameshift), but also by the protein expression level, molecular weight, and amino acid content of the altered protein. This in vitro analysis of SOX10 mutations thus provides a deeper understanding of the mechanisms resulting in specific WS subtypes and allows better prediction of the phenotypic manifestations, though it may not be always applicable to in vivo findings without further investigations.Publication Metadata only A preliminary result of lamtakong embankment dam safety assessment using integrated subsurface electrical resistivity and shear wave velocity model(2020-01-01) P. Amatyakul; K. Phueak-Im; P. Morhrasi; T. Suklim; Mahidol University; Royal Irrigation Department; Science© EAGE 2020. Clustering model using integrated subsurface electrical resistivity and shear wave velocity model provides conspicuously subsurface structure of the Lamtakong embankment dam as show in Fig 1. Furthermore, the Anomaly is found in manual method located around elevation at 250 meters, and distance at 250 meters. The resistivity and velocity of the anomaly are low, so that can be interpreted as a possible leakage and internal erosion zone of the Lamtakong embankment dam. The anomaly is located at the foundation of the dam. Incidentally, the automatic method developed by fuzzy c-means clustering algorithm and selected center method is incomplete. In future study, considering other factors may develop the data grouping of automatic method such as engineer factor.Publication Metadata only Megakaryocytic Expansion in Gilteritinib-Treated Acute Myeloid Leukemia Patients Is Associated With AXL Inhibition(2020-12-09) Kran Suknuntha; Yoon Jung Choi; Ho Sun Jung; Aditi Majumder; Sujal Shah; Igor Slukvin; Erik A. Ranheim; University of Wisconsin-Madison; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Wisconsin National Primate Research Center© Copyright © 2020 Suknuntha, Choi, Jung, Majumder, Shah, Slukvin and Ranheim. Numerous recurrent genetic mutations are known to occur in acute myeloid leukemia (AML). Among these common mutations, Fms-like tyrosine kinase 3 remains as one of the most frequently mutated genes in AML. We observed apparent marrow expansion of megakaryocytes in three out of six patients with Flt3-mutated AML following treatment with a recently FDA-approved Flt3 inhibitor, gilteritinib which possesses activity against internal tandem duplication and tyrosine kinase domain Flt3 mutations and also inhibits tyrosine kinase AXL. To assess whether biopsy findings can be attributed to promotion of megakaryocytic (Mk) differentiation with gilteritinib, we devised a cellular assay by overexpressing double mutated Flt3-ITDY591F/Y919F in chronic myeloid leukemia cell line K562 to study Mk differentiation in the presence of Flt3 and AXL inhibitors with non-mutually exclusive mechanisms. These experiments demonstrated the lack of direct effect Flt3 inhibitors gilteritinib and quizartinib on megakaryocytic differentiation at either transcriptional or phenotypic levels, and highlighted antileukemic effects of AXL receptor tyrosine kinase inhibitor and its potential role in megakaryocytic development.Publication Metadata only Water Level Detection from CCTV Cameras using a Deep Learning Approach(2020-11-16) Punyanuch Borwarnginn; Jason H. Haga; Worapan Kusakunniran; National Institute of Advanced Industrial Science and Technology; Mahidol University© 2020 IEEE. Natural disasters are a global problem that causes widespread losses and damage. A system to provide timely information is required in order to help reduce losses. Flooding is one of the major natural disasters that requires a monitoring and detection system. The traditional flood detection systems use remote sensors such as river water levels and rainfall to provide information to both disaster management professionals and the general public. There is an attempt to use visual information such as CCTV cameras to detect extreme flooding events; however, it requires human experts and consistent attention to monitor any changes. In this paper, we introduce an approach to the automatic river water level detection using deep learning to determine the water level from surveillance cameras. The model achieves 93% accuracy using a single camera location and 83% accuracy using multiple camera locations.Publication Metadata only A hybrid electronic nose system for discrimination of pathogenic bacterial volatile compounds(2020-12-21) Thara Seesaard; Chadinee Thippakorn; Teerakiat Kerdcharoen; Sumana Kladsomboon; Kanchanaburi Rajabhat University; Mahidol University© The Royal Society of Chemistry. A hybrid electronic nose comprising an array of three organic-inorganic nanocomposite gas sensors [zinc tetra tert-butyl phthalocyanine (ZnTTBPc), zinc tetra-phenyl porphyrin (ZnTPP), and cobalt tetraphenyl-porphyrin (CoTPP)] coupled with three commercial metal-oxide semiconductor gas sensors (TGS 2444, TGS 2603 and TGS 2620) was developed to discriminate bacterial volatile compounds. Each type of gas sensor had its own strengths and weaknesses in terms of its capability to detect complex odors from the five different bacterial species tested. Bacterial samples were controlled at a fixed initial bacterial concentration by measuring the optical density at 600 nm of the culture suspensions. A comparative evaluation of the volatile compound fingerprints from five bacterial species grown in Luria-Bertani medium was conducted to identify the optimal incubation time for detection of volatile biomarkers to discriminate among bacteria. The results suggest that the hybrid electronic nose was indeed able to discriminate among the bacterial species and culture media, with a variance based on contributions of 92.4% from PC1 and 7.2% from PC2, at an incubation time of 6 hours. Furthermore, the results of hierarchical cluster analysis showed that bacterial odor data formed two major bacterial groups, with the maximum cluster distance close to 25. Intra-group similarity was demonstrated as the two bacterial species (E. cloacae and P. aeruginosa) from among the Gram-negative bacteria had a greater similarity with a cluster distance close to 4. Finally, the minimum distance between E. cloacae and S. Typhi was approximately 1, at an equal distance from E. coli and S. aureus.Publication Metadata only An IDS rule redundancy verification(2020-11-04) Piyawat Noiprasong; Assadarat Khurat; Mahidol UniversityCopyright © JCSSE 2020 - 17th International Joint Conf. on Computer Science and Software Engineering. Intrusion Detection System (IDS) is a network security software and hardware widely used to detect anomaly network traffics by comparing the traffics against rules specified beforehand. Snort is one of the most famous open-source IDS system. To write a rule, Snort specifies structure and values in Snort manual. This specification is expressive enough to write in different way with the same meaning. If there are rule redundancy, it could distract performance. We, thus, propose a proof of semantical issues for Snort rule and found four pairs of Snort rule combinations that can cause redundancy. In addition, we create a tool to verify such redundancy between two rules on the public rulesets from Snort community and Emerging threat. As a result of our test, we found several redundancy issues in public rulesets if the user enables commented rules.