Publication: Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications
Issued Date
2020-12-16
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ISSN
14203049
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2-s2.0-85098743725
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules (Basel, Switzerland). Vol.25, No.24 (2020)
Suggested Citation
Saravut Satitsri, Chatchai Muanprasat Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications. Molecules (Basel, Switzerland). Vol.25, No.24 (2020). doi:10.3390/molecules25245961 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60868
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Title
Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications
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Abstract
Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.