Publication: Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)
| dc.contributor.author | Juthamas Yosudjai | en_US |
| dc.contributor.author | Sopit Wongkham | en_US |
| dc.contributor.author | Siwanon Jirawatnotai | en_US |
| dc.contributor.author | Worasak Kaewkong | en_US |
| dc.contributor.other | Faculty of Medicine, Khon Kaen University | en_US |
| dc.contributor.other | Naresuan University | en_US |
| dc.contributor.other | Faculty of Medicine, Siriraj Hospital, Mahidol University | en_US |
| dc.date.accessioned | 2020-01-27T07:58:42Z | |
| dc.date.available | 2020-01-27T07:58:42Z | |
| dc.date.issued | 2019-01-01 | en_US |
| dc.description.abstract | © 2019, Spandidos Publications. All rights reserved. Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post‑transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed. | en_US |
| dc.identifier.citation | Biomedical Reports. Vol.10, No.3 (2019), 147-155 | en_US |
| dc.identifier.doi | 10.3892/br.2019.1188 | en_US |
| dc.identifier.issn | 20499442 | en_US |
| dc.identifier.issn | 20499434 | en_US |
| dc.identifier.other | 2-s2.0-85062662624 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/50396 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062662624&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review) | en_US |
| dc.type | Review | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062662624&origin=inward | en_US |