Publication: Drug repurposing of minocycline against dengue virus infection
Issued Date
2016-09-09
Resource Type
ISSN
10902104
0006291X
0006291X
Other identifier(s)
2-s2.0-84980344069
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biochemical and Biophysical Research Communications. Vol.478, No.1 (2016), 410-416
Suggested Citation
Shilpa Lekshmi Leela, Chatchawan Srisawat, Gopinathan Pillai Sreekanth, Sansanee Noisakran, Pa thai Yenchitsomanus, Thawornchai Limjindaporn Drug repurposing of minocycline against dengue virus infection. Biochemical and Biophysical Research Communications. Vol.478, No.1 (2016), 410-416. doi:10.1016/j.bbrc.2016.07.029 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42896
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Drug repurposing of minocycline against dengue virus infection
Other Contributor(s)
Abstract
© 2016 Elsevier Inc. Dengue virus infection is one of the most common arthropod-borne viral diseases. A complex interplay between host and viral factors contributes to the severity of infection. The antiviral effects of three antibiotics, lomefloxacin, netilmicin, and minocycline, were examined in this study, and minocycline was found to be a promising drug. This antiviral effect was confirmed in all four serotypes of the virus. The effects of minocycline at various stages of the viral life cycle, such as during viral RNA synthesis, intracellular envelope protein expression, and the production of infectious virions, were examined and found to be significantly reduced by minocycline treatment. Minocycline also modulated host factors, including the phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2). The transcription of antiviral genes, including 2′-5′-oligoadenylate synthetase 1 (OAS1), 2′-5′-oligoadenylate synthetase 3 (OAS3), and interferon α (IFNA), was upregulated by minocycline treatment. Therefore, the antiviral activity of minocycline may have a potential clinical use against Dengue virus infection.