Publication: Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E
Issued Date
1991-09-01
Resource Type
ISSN
15728773
09335854
09335854
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2-s2.0-0025935816
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Mahidol University
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SCOPUS
Bibliographic Citation
Biology of Metals. Vol.4, No.3 (1991), 162-165
Suggested Citation
Tim G. St. Pierre, Kim C. Tran, John Webb, David J. Macey, Brigid R. Heywood, Nicholas H. Sparks, Vanessa J. Wade, Stephen Manna, Pensri Pootrakul Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E. Biology of Metals. Vol.4, No.3 (1991), 162-165. doi:10.1007/BF01141308 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21967
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Title
Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E
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Abstract
The cores of ferritins isolated from different organs of human subjects with β-thalassemia/hemoglobin E (β-thal/HbE) disease have different size distributions and crystallinities depending on the source organ. These patients have not been treated by hypertransfusion regimen or iron chelation therapy. β-Thal/HbE spleens and livers yield ferritin cores which are less crystalline than those isolated from normal spleens and livers, reflecting the more rapid deposition of iron in the diseased state. Ferritins isolated from the hearts and pancreases of β-thal/HbE subjects were found to have larger, more crystalline cores than those from the β-thal/HbE livers and spleens, possibly as a consequence of the role of the heart and pancreas as long-term iron deposition sites in this iron overload pathology. © 1991 Springer-Verlag.