Publication:
Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa

Issued Date

2012-11-01

Resource Type

Article

ISSN

15461718
10614036

DOI

10.1038/ng.2423

Other identifier(s)

2-s2.0-84868201561

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Genetics. Vol.44, No.11 (2012), 1215-1221

Suggested Citation

Chinyere K. Okoro, Robert A. Kingsley, Thomas R. Connor, Simon R. Harris, Christopher M. Parry, Manar N. Al-Mashhadani, Samuel Kariuki, Chisomo L. Msefula, Melita A. Gordon, Elizabeth De Pinna, John Wain, Robert S. Heyderman, Stephen Obaro, Pedro L. Alonso, Inacio Mandomando, Calman A. MacLennan, Milagritos D. Tapia, Myron M. Levine, Sharon M. Tennant, Julian Parkhill, Gordon Dougan Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nature Genetics. Vol.44, No.11 (2012), 1215-1221. doi:10.1038/ng.2423 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13585

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Title

Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa

Author(s)

Chinyere K. Okoro
 Robert A. Kingsley
 Thomas R. Connor
 Simon R. Harris
 Christopher M. Parry
 Manar N. Al-Mashhadani
 Samuel Kariuki
 Chisomo L. Msefula
 Melita A. Gordon
 Elizabeth De Pinna
 John Wain
 Robert S. Heyderman
 Stephen Obaro
 Pedro L. Alonso
 Inacio Mandomando
 Calman A. MacLennan
 Milagritos D. Tapia
 Myron M. Levine
 Sharon M. Tennant
 Julian Parkhill
 Gordon Dougan

Other Contributor(s)

Wellcome Trust Sanger Institute
 Mahidol University
 University of Liverpool
 Kenya Medical Research Institute
 University of Malawi College of Medicine
 University of Malawi
 Health Protection Agency
 University of East Anglia
 University of Bristol
 Michigan State University
 National Hospital, Abuja
 Universitat de Barcelona
 Centro de Investigação em Saúde de Manhiça (CISM)
 Instituto Nacional de Saude Maputo
 Novartis Vaccines Institute for Global Health
 University of Birmingham
 University of Maryland, Baltimore

Abstract

A highly invasive form of non-typhoidal Salmonella (iNTS) disease has recently been documented in many countries in sub-Saharan Africa. The most common Salmonella enterica serovar causing this disease is Typhimurium (Salmonella Typhimurium). We applied whole-genome sequence-based phylogenetic methods to define the population structure of sub-Saharan African invasive Salmonella Typhimurium isolates and compared these to global Salmonella Typhimurium populations. Notably, the vast majority of sub-Saharan invasive Salmonella Typhimurium isolates fell within two closely related, highly clustered phylogenetic lineages that we estimate emerged independently ∼52 and ∼35 years ago in close temporal association with the current HIV pandemic. Clonal replacement of isolates from lineage I by those from lineage II was potentially influenced by the use of chloramphenicol for the treatment of iNTS disease. Our analysis suggests that iNTS disease is in part an epidemic in sub-Saharan Africa caused by highly related Salmonella Typhimurium lineages that may have occupied new niches associated with a compromised human population and antibiotic treatment. © 2012 Nature America, Inc. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/13585

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Scopus 2011-2015