Publication: Pneumococcal disease in Thailand
Issued Date
2021-01-01
Resource Type
ISSN
18783511
12019712
12019712
Other identifier(s)
2-s2.0-85097448912
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases. Vol.102, (2021), 429-436
Suggested Citation
Amgad Gamil, Kulkanya Chokephaibulkit, Wanatpreeya Phongsamart, Chonnamet Techasaensiri, Barameht Piralam, Ruangwit Thamaree Pneumococcal disease in Thailand. International Journal of Infectious Diseases. Vol.102, (2021), 429-436. doi:10.1016/j.ijid.2020.10.048 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78875
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Title
Pneumococcal disease in Thailand
Abstract
This review examines the epidemiology of pneumococcal disease, serotype prevalence, antibiotic resistance, and national vaccination recommendations in Thailand. The incidence of invasive pneumococcal disease (IPD) and annualized hospitalization rates for pneumococcal bacteremia in Thailand were highest in children aged <5 years and the elderly. The most prevalent serotype is serotype 6B, which is included in both the 10- and 13-valent pneumococcal conjugate vaccines (PCV10 [also known as PHiD-CV] and PCV13, respectively) registered in Thailand. Other common serotypes are 14, 18C, 19F, and 23F (included in both PCVs) and 6A and 19A (only included in PCV13). PCV10/PHiD-CV and PCV13 should cover 48.8%–74% and 73.2%–92% of isolates among children aged ≤5 years, respectively, and 40.0%–47.9% and 58.3%–60.9% of isolates among adults aged ≥65 years. Only PCV13 is licensed for adults in Thailand. Pneumococcal isolates were most commonly resistant to erythromycin, cefuroxime, and penicillin. Despite their demonstrated cost effectiveness and efficacy in reducing nasopharyngeal carriage and IPD, PCVs are not included in the Thai national immunization program. The serotype-specific IPD incidence in Thailand suggests that PCVs will reduce the disease burden in all age groups, but particularly in children and older adults.