Publication: Drug-resistant tuberculosis in children in Thailand
Issued Date
2013-10-01
Resource Type
ISSN
10273719
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2-s2.0-84884640386
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Tuberculosis and Lung Disease. Vol.17, No.10 (2013), 1279-1284
Suggested Citation
K. Lapphra, C. Sutthipong, S. Foongladda, N. Vanprapar, W. Phongsamart, O. Wittawatmongkol, R. Saksawad, Kulkanya Chokephaibulkit Drug-resistant tuberculosis in children in Thailand. International Journal of Tuberculosis and Lung Disease. Vol.17, No.10 (2013), 1279-1284. doi:10.5588/ijtld.13.0858 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32133
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Title
Drug-resistant tuberculosis in children in Thailand
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Abstract
SETTING: Few data on drug-resistant (DR) tuberculosis (TB) in children are available in Thailand. OBJECTIVES: To evaluate the rate, clinical features and risk of DR-TB in children. DESIGN: Observational prospective study conducted in children diagnosed with TB at a tertiary care centre in Bangkok. RESULTS: Of 230 children diagnosed with TB, the median age was 6.5 years; 63% had identified adult source cases, and only 7% had received prior isoniazid treatment for latent tuberculous infection. Of the 195 (85%) specimens submitted, 57 (25%) were positive using culture or polymerase chain reaction. Of the 53 positive specimens available for drug susceptibility testing (DST), 18 (34%) had any resistance, 13 (24.5%) were monoresistant, 2 (3.8%) polyresistant and 3 (5.7%) were multidrug-resistant. In multivariate analysis, prior TB treatment (P < 0.001), presence of atelectasis (P = 0.039) or lobar consolidation (P = 0.012) on chest X-ray were associated with DR-TB. DR-TB required longer treatment but there were no differences in rate of cure, treatment completion or death. CONCLUSIONS: The high rate of DR-TB underscores the importance of routine DST. History of treatment and drug susceptibility in source cases was useful in guiding initial treatment in children. © 2013 The Union.