Publication: Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand
Accepted Date
2008-06-02
Issued Date
2008-06-02
Copyright Date
2008
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Phimpraphi W, Paul RE, Yimsamran S, Puangsa-art S, Thanyavanich N, Maneeboonyang W. Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand. Malar J. 2008 Jun 2;7:99.
Suggested Citation
Waraphon Phimpraphi, วราพร พิมพ์ประไพ, Paul, Richard E., Surapon Yimsamran, สุรพล ยิ้มสำราญ, Supalarp Puangsa-art, สุภลาภ พวงสะอาด, Nipon Thanyavanich, นิพนธ์ ธัญญวานิช, Wanchai Maneeboonyang, วรรณไชย มณีบุญยัง, Sutthiporn Prommongkol, Samarn Sornklom, Wutthichai Chaimungkun, วุฒิชัย ชัยมุงคุณ, Chavez, Irwin F., Blanc, Herve, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Anavaj Sakuntabhai, Pratap Singhasivanon, ประตาป สิงหศิวานนท์ Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand. Phimpraphi W, Paul RE, Yimsamran S, Puangsa-art S, Thanyavanich N, Maneeboonyang W. Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand. Malar J. 2008 Jun 2;7:99.. doi:10.1186/1475-2875-7-99 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/715
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Title
Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand
Author(s)
Waraphon Phimpraphi
วราพร พิมพ์ประไพ
Paul, Richard E.
Surapon Yimsamran
สุรพล ยิ้มสำราญ
Supalarp Puangsa-art
สุภลาภ พวงสะอาด
Nipon Thanyavanich
นิพนธ์ ธัญญวานิช
Wanchai Maneeboonyang
วรรณไชย มณีบุญยัง
Sutthiporn Prommongkol
Samarn Sornklom
Wutthichai Chaimungkun
วุฒิชัย ชัยมุงคุณ
Chavez, Irwin F.
Blanc, Herve
Sornchai Looareesuwan
ศรชัย หลูอารีย์สุวรรณ
Anavaj Sakuntabhai
Pratap Singhasivanon
ประตาป สิงหศิวานนท์
วราพร พิมพ์ประไพ
Paul, Richard E.
Surapon Yimsamran
สุรพล ยิ้มสำราญ
Supalarp Puangsa-art
สุภลาภ พวงสะอาด
Nipon Thanyavanich
นิพนธ์ ธัญญวานิช
Wanchai Maneeboonyang
วรรณไชย มณีบุญยัง
Sutthiporn Prommongkol
Samarn Sornklom
Wutthichai Chaimungkun
วุฒิชัย ชัยมุงคุณ
Chavez, Irwin F.
Blanc, Herve
Sornchai Looareesuwan
ศรชัย หลูอารีย์สุวรรณ
Anavaj Sakuntabhai
Pratap Singhasivanon
ประตาป สิงหศิวานนท์
Corresponding Author(s)
Other Contributor(s)
Abstract
BACKGROUND: Clinical case treatment of malaria infections where Plasmodium
falciparum and Plasmodium vivax are sympatric has achieved effective reductions
in P. falciparum prevalence and incidence rates, but has been less successful for
P. vivax. The high transmissibility of P. vivax and its capacity to relapse have
been suggested to make it a harder parasite species to control.
METHODS: A clinical malaria case treatment programme was carried out over a
decade in a Karen community composed of seven hamlets on the Thai-Myanmar border.
RESULTS: From 1994 to 2004, prevalence rates of both P. falciparum and P. vivax
decreased by 70-90% in six of the seven study hamlets, but were unchanged in one
hamlet. Overall, incidence rates decreased by 72% and 76% for P. falciparum and
P. vivax respectively over the period 1999-2004. The age-incidence and prevalence
curves suggested that P. vivax was more transmissible than P. falciparum despite
a greater overall burden of infection with P. falciparum. Male gender was
associated with increased risk of clinical presentation with either parasite
species. Children (< 15 years old) had an increased risk of presenting with P.
vivax but not P. falciparum.
CONCLUSION: There was a considerable reduction in incidence rates of both P.
vivax and P. falciparum over a decade following implementation of a case
treatment programme. The concern that intervention methods would inadvertently
favour one species over another, or even lead to an increase in one parasite
species, does not appear to be fulfilled in this case.