Publication: Modulation of stress and virulence in Listeria monocytogenes
Issued Date
2008-08-01
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ISSN
0966842X
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2-s2.0-48149114272
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Microbiology. Vol.16, No.8 (2008), 388-396
Suggested Citation
Soraya Chaturongakul, Sarita Raengpradub, Martin Wiedmann, Kathryn J. Boor Modulation of stress and virulence in Listeria monocytogenes. Trends in Microbiology. Vol.16, No.8 (2008), 388-396. doi:10.1016/j.tim.2008.05.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19307
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Title
Modulation of stress and virulence in Listeria monocytogenes
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Abstract
Listeria monocytogenes can respond rapidly to changing environmental conditions, as illustrated by its ability to transition from a saprophyte to an orally transmitted facultative intracellular pathogen. Differential associations between various alternative σ factors and a core RNA polymerase provide a transcriptional mechanism for regulating bacterial gene expression that is crucial for survival in rapidly changing conditions. Alternative σ factors are key components of complex L. monocytogenes regulatory networks that include multiple transcriptional regulators of stress-response and virulence genes, regulation of genes encoding other regulators, and regulation of small RNAs. In this article, the contributions of various σ factors to L. monocytogenes stress response and virulence are described. © 2008 Elsevier Ltd. All rights reserved.