Publication: The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais
Issued Date
2009-01-01
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09120009
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2-s2.0-60849115832
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Biochemistry and Nutrition. Vol.44, No.1 (2009), 104-110
Suggested Citation
Kanjana Suriyaprom, Benjaluck Phonrat, Pisit Namjuntra, Siriporn Chanchay, Rungsunn Tungtrongchitr The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais. Journal of Clinical Biochemistry and Nutrition. Vol.44, No.1 (2009), 104-110. doi:10.3164/jcbn.08-224 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27338
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Title
The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais
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Abstract
The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes. We performed a case-control study in representative sample of 200 Thai volunteers, 105 controls and 95 type 2 diabetes subjects. The purposes of the present study were to investigate the association between two SNPs (single nucleotide polymorphisms) in the resistin gene, at positions +299(G>A) and -420(C>G), and biochemical parameters; to determine whether these polymorphisms are linked to increased risk of type 2 diabetes. At position +299(G>A) of the resistin gene, the resistin concentration among type 2 diabetes subjects was significantly higher in GA/AA genotypes (3.40 ng/ml) than the GG genotype (1.99 ng/ml). Resistin gene polymorphism at position +299(G>A) in type 2 diabetes patients was significantly more frequent than in the control group (p = 0.004). Polymorphism at position -420(C>G) showed no significant relationship with type 2 diabetes (p = 0.095). Logistic regression analysis was shown that +299(G>A) gene polymorphism was increased risk factors for type 2 diabetes (p = 0.013). In conclusion, these finding suggest that resistin gene polymorphism at position +299(G>A) has impact on the increased resistin concentrations and may influence susceptibility to type 2 diabetes in Thais.