Publication: Structural definition of the A(*)74 group: Implications for matching in bone marrow transplantation with alternative donors
Issued Date
1996-01-01
Resource Type
ISSN
00012815
Other identifier(s)
2-s2.0-0029658835
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Mahidol University
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SCOPUS
Bibliographic Citation
Tissue Antigens. Vol.48, No.3 (1996), 205-209
Suggested Citation
R. Blasczyk, J. Wehling, D. Önaldi-Mohr, V. Rebmann, D. Chandanayingyong, H. Grosse-Wilde Structural definition of the A(*)74 group: Implications for matching in bone marrow transplantation with alternative donors. Tissue Antigens. Vol.48, No.3 (1996), 205-209. doi:10.1111/j.1399-0039.1996.tb02630.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17571
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Title
Structural definition of the A(*)74 group: Implications for matching in bone marrow transplantation with alternative donors
Abstract
We have identified two new A(*)74 alleles (A(*)7402 and 7403) in two unrelated individuals. A(*)7402 differs from A(*)7401 by a single amino acid substitution in the signal peptide and may be the result of a gene conversion event at the 3' end of exon 1. A(*)7403 differs from A(*)7401 by a single amino acid exchange in the α1 domain and is most likely due to a point mutation in exon 2, since no HLA class I donor allele has been found. Since A(*)7402 appears to be the ancestor of the other two A(*)74 alleles, it is possible that A(*)7401 and 7403 have been created by successive point mutations. The sequences of the expressed proteins of A(*)7401 and 7402 are identical. The heavy chain sequence of A(*)7403 differs from these alleles at the crucial residue 79 which is located in the sequence stretch of the α1 α-Helix where the Bw4/Bw6 determinants have been identified and which probably affects TCR interaction. This variation can therefore be expected to stimulate alloreactive T cells, graft rejection and graft versus host disease emphasizing the relevance for matching in bone marrow transplantation with alternative donors.