Publication: Motor blockade associated with continuous epidural infusion after abdominal hysterectomy: A randomized controlled trial comparing 0.1% ropivacaine-plus- fentanyl versus 0.2% ropivacaine-alone
Issued Date
2004-06-01
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ISSN
13660071
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2-s2.0-2342591379
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Mahidol University
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SCOPUS
Bibliographic Citation
Acute Pain. Vol.6, No.1 (2004), 15-21
Suggested Citation
Somboon Thienthong, Wimonrat Krisanaprakornkit, Duenpen Horatanaruang, Panaratana Yimyam, Bandit Thinkhamrop, Jariya Lertakyamanee Motor blockade associated with continuous epidural infusion after abdominal hysterectomy: A randomized controlled trial comparing 0.1% ropivacaine-plus- fentanyl versus 0.2% ropivacaine-alone. Acute Pain. Vol.6, No.1 (2004), 15-21. doi:10.1016/j.acpain.2004.02.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21637
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Title
Motor blockade associated with continuous epidural infusion after abdominal hysterectomy: A randomized controlled trial comparing 0.1% ropivacaine-plus- fentanyl versus 0.2% ropivacaine-alone
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Abstract
We compared rates of motor blockade, analgesia, adverse effects and patient satisfaction of 0.1% ropivacaine+fentanyl versus 0.2% ropivacaine-alone in a randomized, controlled trial. Fifty-four women who had undergone abdominal hysterectomy were randomly allocated into two groups to receive an epidural block at L1-2or L2-3: group R received 0.2% ropivacaine-alone and group RF received 0.1% ropivacaine plus 2 μg fentanyl/ml, both at 8 ml/h. Rescue analgesia was provided via a morphine-loaded PCA device. Motor blockade (using a modified Bromage scale), pain intensity (visual analogue scale (VAS)), morphine consumption, level of sensory blockade and adverse effects, were measured at 4, 8 and 21 h after infusion. Patient satisfaction with pain management was assessed at the end of the study. The rates of motor blockade were not different at 8 h after infusion but at 21 h, group RF had significantly less motor blockade than group R. There were no differences in VAS, level of sensory blockade, adverse effects and patient satisfaction. Morphine consumption at each measurement was comparable but the total amount used by group RF was less than group R (12 mg versus 20 mg, P=0.049). Therefore, 0.1% ropivacaine with fentanyl 2 μg/ml appears to offer advantages over 0.2% ropivacaine-alone. © 2004 Elsevier B.V. All rights reserved.