Publication: Safety and efficacy of fermented olive tree leaf extract for treatment of paronychia and neoscytalidium dimidiatum onychomycosis: A pilot study
Issued Date
2018-09-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-85054732719
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), 1269-73
Suggested Citation
Sumanas Bunyaratavej, Charussri Leeyaphan, Pattriya Chanyachailert, Chuda Rujitharanawong, Waritch Kobwanthanakun, Sutasinee Phaitoonwattanakij, Lalita Matthapan, Kamonpan Lertrujiwanit Safety and efficacy of fermented olive tree leaf extract for treatment of paronychia and neoscytalidium dimidiatum onychomycosis: A pilot study. Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), 1269-73. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46366
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Safety and efficacy of fermented olive tree leaf extract for treatment of paronychia and neoscytalidium dimidiatum onychomycosis: A pilot study
Other Contributor(s)
Abstract
© 2018, Medical Association of Thailand. All rights reserved. Objective: To evaluate the efficacy and safety of Olea europaea leaf extract for treatment of chronic paronychia and Neoscytalidium dimidiatum onychomycosis. Materials and Methods: The present prospective pilot study was conducted. O. europaea leaf extract was applied twice a day. Assessment parameters were evaluated at baseline, 2-, 4-, and 6-months. Results: A total of 9 chronic paronychia patients and 9 N. dimidiatum onychomycosis patients were included. Concerning chronic paronychia, thumb nail was common affecting site. Candida albicans revealed in 6 (66.7%). Comparing with baseline, severity of chronic paronychia was significantly reduced within 6 months after treatment (p = 0.021). For N. dimidiatum onychomycosis, all affected on big toenails. Mean normal nail length at baseline was 7.1 mm, which significantly improved after 6 months treatment to 8.9 mm (p = 0.016). Nail thickness significantly reduced after 6 months treatment (p = 0.001). No adverse events were observed in the present study. Conclusion: O. europaea leaf extract has been shown to be an effective and safe alternative topical treatment for chronic paronychia from Candida spp. infection and N. dimidiatum onychomycosis. No side effect was found in the present study. ClinicalTrials.gov identifier: NCT02464826.