Publication: In vivo and in vitro responses to quinine and quinidine of Plasmodium falciparum
Issued Date
1988-01-01
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ISSN
00439686
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2-s2.0-0023715921
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Mahidol University
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SCOPUS
Bibliographic Citation
Bulletin of the World Health Organization. Vol.66, No.3 (1988), 347-352
Suggested Citation
A. Sabchareon, T. Chongsuphajaisiddhi, V. Sinhasivanon, P. Chanthavanich, P. Attanath In vivo and in vitro responses to quinine and quinidine of Plasmodium falciparum. Bulletin of the World Health Organization. Vol.66, No.3 (1988), 347-352. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15646
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Title
In vivo and in vitro responses to quinine and quinidine of Plasmodium falciparum
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Abstract
A total of 66 Thai children with uncomplicated falciparum malaria were treated orally with regimens of either quinine or quinidine. Radical cures were observed in 85% (28 of 33) of the children who received quinine and in 88% (29 out of 33) of those who received quinidine. Treatment failures in both groups were RI responses. The mean trough level of quinidine (10 μmol/l) was about 2.5-times less than that of quinine (25 μmol/l). The electrocardiograms of the two treatment groups differed significantly in that there was an acute prolongation of the QT(c) interval in 56% of those who received quinidine compared with 21.0% of those given quinine. In vitro assays of the pre-treatment drug susceptibilities of the isolates of Plasmodium falciparum indicated that the mean minimum inhibitory concentration (MIC) for quinidine (1.44 μmol/l) was about half that for quinine (3.02 μmol/l). Although both drugs are equally effective, quinine is recommended for treatment of multidrug-resistant malaria in paediatric patients, primarily because of the cardiac effects produced by quinidine.