Publication: Venous thromboembolism prophylaxis in critically ill patients
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Issued Date
2015-03-01
Resource Type
ISSN
10989064
00946176
00946176
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2-s2.0-84928473250
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Mahidol University
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SCOPUS
Bibliographic Citation
Seminars in Thrombosis and Hemostasis. Vol.41, No.1 (2015), 68-74
Suggested Citation
Kochawan Boonyawat, Mark A. Crowther Venous thromboembolism prophylaxis in critically ill patients. Seminars in Thrombosis and Hemostasis. Vol.41, No.1 (2015), 68-74. doi:10.1055/s-0034-1398386 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36500
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Title
Venous thromboembolism prophylaxis in critically ill patients
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Abstract
© 2015 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York. Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is recognized as a common complication in critically ill patients. Risk factors including critical illness, mechanical ventilation, sedative medications, and central venous catheter insertion are major contributing factors to the high risk of VTE. Because of their impaired cardiopulmonary reserve, PE arising from thrombosis in the deep veins of the calf that propagates proximally is poorly tolerated by critically ill patients. Pharmacologic prophylaxis with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) has been shown to decrease the incidence of VTE in medical, surgical, and critically ill patients. As a result, over the past decades, VTE prophylaxis had become a standard of preventive measure in the intensive care unit (ICU). In clinical practice, the rate of VTE prophylaxis varies and may be inadequate in some centers. A perception of a high bleeding risk in critically ill patients is a major concern for most physicians that may lead to inadequate prophylaxis.