Publication: The immunogenicity of intradermal influenza vaccination in COPD patients
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Issued Date
2010-05-28
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ISSN
0264410X
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2-s2.0-77952674091
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.28, No.24 (2010), 4045-4051
Suggested Citation
Benjamas Chuaychoo, Phunsup Wongsurakiat, Arth Nana, Uraiwan Kositanont, Khun Nanta Maranetra The immunogenicity of intradermal influenza vaccination in COPD patients. Vaccine. Vol.28, No.24 (2010), 4045-4051. doi:10.1016/j.vaccine.2010.04.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28705
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Title
The immunogenicity of intradermal influenza vaccination in COPD patients
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Abstract
We evaluated the immunogenicity of a reduced-dose intradermal trivalent, inactivated, split-virion seasonal influenza vaccine compared to that of a conventional intramuscular vaccination in chronic obstructive pulmonary disease (COPD) patients. One hundred and fifty-six COPD patients randomly received either 0.2 ml (6 μg hemagglutinin (HA) per strain) split into two-site intradermal (ID) injections or a single 0.5 ml (15 μg HA per strain) intramuscular (IM) injection. Geometric mean titers, seroconversion factors, seroconversion rates and seroprotection rates at 4 weeks post-vaccination in the ID group were less than those in the IM group. Only the seroconversion factor to influenza B in the ID group was statistically less than in the IM group (18.8 in the ID group, n = 81 versus 37.3 in the IM group, n = 75, p = 0.045). Nevertheless, each strain of the ID vaccination met all the Committee for Proprietary Medicinal Products (CPMP) criteria. Seroprotection rates were above 60% throughout the year in influenza A (H3N2), for at least 6 months in influenza A (H1N1) and at least 4 weeks in influenza B in both ID and IM groups. The reduced-dose intradermal vaccination may be considered for use in COPD patients in a vaccine shortage situation. © 2010 Elsevier Ltd. All rights reserved.