Publication: Association of fatty acid consumption with frailty and mortality among middle-aged and older adults
Issued Date
2020-02-01
Resource Type
ISSN
18731244
08999007
08999007
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2-s2.0-85074967473
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Mahidol University
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SCOPUS
Bibliographic Citation
Nutrition. Vol.70, (2020)
Suggested Citation
Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Kenneth Rockwood Association of fatty acid consumption with frailty and mortality among middle-aged and older adults. Nutrition. Vol.70, (2020). doi:10.1016/j.nut.2019.110610 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49633
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Title
Association of fatty acid consumption with frailty and mortality among middle-aged and older adults
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Abstract
© 2019 Elsevier Inc. Objectives: Despite their role in health and disease, the relationship between fatty acids (FAs) and frailty and mortality remains unclear. The aim of this study was to explore how FA intake is associated with frailty and mortality. Methods: This observational study included 4062 participants ≥50 y of age from the 2003–2006 cohorts of the National Health and Nutrition Examination Survey. A 36-item frailty index (FI) and a 14-item nutrition index (NI) were constructed. We analyzed 29 dietary FA variables. Results: After adjustment for potential covariates and the NI, higher total FAs, saturated FAs (SFAs), and butanoic acid intake were associated with a higher degree of frailty. After an additional adjustment for the FI, higher SFA intake (total, hexanoic acid, octanoic acid, decanoic acid, tetradecanoic acid, hexadecanoic acid, and octadecanoic acid) was associated with higher mortality risk, whereas higher polyunsaturated FAs (total and octadecadienoic acid), ω-3 FAs (total, octadecatrienoic acid, and docosapentaenoic acid), and eicosenoic acid intake was associated with lower mortality risk. Conclusions: Only a higher percentage of SFA intake was associated with both higher frailty and mortality even after considering the degree of nutritional deficits. The effect of SFAs on mortality was evident across levels of frailty. FAs were associated with long-term mortality more often than they with degree of frailty.