Publication: Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men
Issued Date
2016-10-01
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ISSN
10806059
10806040
10806040
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2-s2.0-84988490261
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Mahidol University
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SCOPUS
Bibliographic Citation
Emerging Infectious Diseases. Vol.22, No.10 (2016), 1778-1784
Suggested Citation
Charussri Leeyaphan, Jason J. Ong, Eric P.F. Chow, Fabian Y.S. Kong, Jane S. Hocking, Melanie Bissessor, Christopher K. Fairley, Marcus Chen Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men. Emerging Infectious Diseases. Vol.22, No.10 (2016), 1778-1784. doi:10.3201/eid2210.160986 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41107
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Title
Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men
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Abstract
© 2016, Centers for Disease Control and Prevention (CDC). All rights reserved. Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2= 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.
