Publication: Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases
Issued Date
2001-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0035379335
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.2 (2001), 255-261
Suggested Citation
Srivicha Krudsood, Pratap Singhasivanon, Udomsak Silachamroon, Sombat Treeprasertsuk, Wongphan Kaivipakbanyai, Kobsiri Chalermrut, Nuntaporn Phophak, John Horton, Dennis Kyle, Sornchai Looareesuwan Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.2 (2001), 255-261. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26779
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Title
Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases
Abstract
The spread of falciparum malaria resistant to chloroquine all over Southeast Asian continent has led to increasing use of alternative antimalarial drugs. Halofantrine has been shown to be effective against multidrug resistant Plasmodium falciparum. One hundred and twenty falciparum malaria cases were randomly assigned to one of three different halofantrine regimes. Group I (HA1) received 500 mg three times daily for 3 days (total dose: 4,500 mg), group II (HA2) received 500 mg three times daily for the first and the third day (total dose: 3,000 mg) and group III (HA3) received 500 mg three times for one day followed by 500 mg once daily for 7 days (total dose: 4,500 mg). No significant difference in the cure rate was observed among the three regimes (cure rate: 89%, 73%, 97% respectively). However, the cure rate was significantly higher in the HA3 group when compared to the HA2 group. There were no overt cardiac problems seen in this study. Thus, halofantrine has high efficacy in the recommended treatment dose of 500 mg three times after meals on the first day followed by 500 mg once a day after a meal for 7 days (total dose: 4,500 mg).