Publication: Fabrication and characterization of triple-responsive composite hydrogel for targeted and controlled drug delivery system
Issued Date
2018-04-15
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ISSN
01677322
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2-s2.0-85042023276
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Molecular Liquids. Vol.256, (2018), 90-99
Suggested Citation
C. Siangsanoh, S. Ummartyotin, K. Sathirakul, P. Rojanapanthu, W. Treesuppharat Fabrication and characterization of triple-responsive composite hydrogel for targeted and controlled drug delivery system. Journal of Molecular Liquids. Vol.256, (2018), 90-99. doi:10.1016/j.molliq.2018.02.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45499
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Title
Fabrication and characterization of triple-responsive composite hydrogel for targeted and controlled drug delivery system
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Abstract
© 2018 Elsevier B.V. In this study, to prepare a new magnetic composite hydrogel (Mag-H) based on gelatin/bacterial cellulose (BC), we synthesized gelatin-coated magnetic nanoparticles and then incorporated into the gelatin/BC matrices, followed by chemical crosslinking with glutaraldehyde. The physicochemical properties of Mag-H were evaluated by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), texture analyzer, swelling test, and in vitro drug release behavior using methylene blue (MB) as a model drug. The FTIR spectra showed that glutaraldehyde crosslinked with gelatin. To improve the thermal and mechanical properties of gelatin hydrogel (Gel-H), the BC and magnetic nanoparticles were incorporated into the gelatin network. Due to the superparamagnetism of magnetic nanoparticles, Mag-H possessed a powerful magnetic property for achieving a magnetic targeting. Mag-H had a maximum swelling ratio of 1085 ± 12% in phosphate buffer saline (pH 1.2) at 37 °C, meanwhile its maximum drug release of 80.77 ± 0.33% was observed at the same condition with an external magnetic field application. Interestingly, Mag-H showed temperature-, pH-, and magnetic field-responsive properties, which would be a promising candidate for targeted and controlled drug delivery system.