Publication: Effect of steroids on cerebrospinal fluid penetration of antituberculous drugs in tuberculous meningitis
Issued Date
1991-01-01
Resource Type
ISSN
15326535
00099236
00099236
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2-s2.0-0026099458
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Pharmacology and Therapeutics. Vol.49, No.1 (1991), 6-12
Suggested Citation
Sming Kaojarern, Kingfah Supmonchai, Prida Phuapradit, Chintana Mokkhavesa, sarinee Krittiyanunt Effect of steroids on cerebrospinal fluid penetration of antituberculous drugs in tuberculous meningitis. Clinical Pharmacology and Therapeutics. Vol.49, No.1 (1991), 6-12. doi:10.1038/clpt.1991.2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22223
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Title
Effect of steroids on cerebrospinal fluid penetration of antituberculous drugs in tuberculous meningitis
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Abstract
Sixteen patients treated with oral isoniazid, pyrazinamide, rifampin, and intramuscular streptomycin for tuberculous meningitis were studied. The concentrations of isoniazid, pyrazinamide, rifampin, and streptomycin in cerebrospinal fluid (CSF) obtained 3 hours after administration were 2.40, 34.78, 0.29, and 3.78 μg/ml, respectively. The CSF concentrations of isoniazid and pyrazinamide were well above the minimum inhibitory concentration for Mycobacterium tuberculosis. Concentrations of rifampin and streptomycin were above the minimal inhibitory concentration initially but declined below the minimal inhibitory concentration at later times. The CSF penetration of isoniazid, pyrazinamide, rifampin, and streptomycin was about 89%, 91%, 5%, and 20%, respectively. In eight patients who received antituberculous drugs in combination with steroids, the mean CSF and serum concentrations, as well as CSF/serum ratios at various intervals of treatment, were not statistically different (p > 0.05) from those of the eight patients who did not receive steroids. © 1991.