Publication: The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity
Issued Date
2015-01-01
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ISSN
18811361
02874547
02874547
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2-s2.0-84922182856
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Mahidol University
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SCOPUS
Bibliographic Citation
Dental Materials Journal. Vol.34, No.1 (2015), 31-40
Suggested Citation
Yossakit Lochaiwatana, Suchit Poolthong, Isao Hirata, Masayuki Okazaki, Somporn Swasdison, Noppakun Vongsavan The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity. Dental Materials Journal. Vol.34, No.1 (2015), 31-40. doi:10.4012/dmj.2014-102 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35877
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Title
The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity
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Abstract
© 2015, Japanese Society for Dental Materials and Devices. All rights reserved. Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization. In this study we formulated a novel varnish containing potassium chloride and fluoridated hydroxyapatite and evaluated its physical properties and cytotoxicity. Potassium ion release from the varnish was measured. Dentin permeability was evaluated by measuring the hydraulic conductance of etched dentin discs treated with the varnish. The direct contact test and MTT assay were performed to evaluate the varnish’s cytotoxicity. We found that the varnish released potassium ions over 6 h, and demonstrated a statistically higher reduction in dentin permeability compared to commercial fluoride varnish or control. Dentin disc scanning electron microscopy images demonstrated occluded dentinal tubules in the novel varnish group after brushing. The cytotoxicity tests indicated the varnish was biocompatible with gingival and pulpal fibroblasts. We propose the novel varnish is a potential material for use in hypersensitivity management.