Publication: Alterations of striatal cholinergic receptors after lesioning of the substantia nigra
6
Issued Date
1998-08-01
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ISSN
01970186
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2-s2.0-0032142784
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Mahidol University
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SCOPUS
Bibliographic Citation
Neurochemistry International. Vol.33, No.2 (1998), 187-193
Suggested Citation
Yupin Sanvarinda, Laddawan Phivthongngam, Piyarat Govitrapong Alterations of striatal cholinergic receptors after lesioning of the substantia nigra. Neurochemistry International. Vol.33, No.2 (1998), 187-193. doi:10.1016/S0197-0186(98)00005-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18295
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Title
Alterations of striatal cholinergic receptors after lesioning of the substantia nigra
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Abstract
Dopamine deficiency syndrome is known to cause cholinergic hyperactivity. Therefore, it was hypothesized that the said phenomenon may be due to enhanced cholinergic receptor functions. In the present study we examined the changes in striatal dopaminergic and cholinergic receptors in unilateral substantia nigra lesioned rats that showed vigorous ipsilateral rotation (total turns > 300) in response to apomorphine (1 mg kg-1ip). [3H] Spiperone ([3H]-SP) and [3H]-quinuclidinyl benzilate ([3H]-QNB) bindings were performed in the striata of the lesioned animals. There was no significant difference in the dissociation equilibrium constant values (K(d)) between the lesioned and non-lesioned sides. However, a significant difference in the maximum receptor density (B(max) of both [3H]-SP and [3H]-QNB bindings was observed between the lesioned and non-lesioned sides. The B(max) of [3H]-SP binding was significantly decreased on the lesioned side, whereas the B(max) of the [3H]-QNB binding was significantly increased. These results support the hypothesis that deficiencies of the dopaminergic system cause overactivity of the cholinergic system in the striatum.