Publication: Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata
Issued Date
2013-01-01
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ISSN
15559475
1934578X
1934578X
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2-s2.0-84886815888
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.8, No.9 (2013), 1205-1208
Suggested Citation
Kanidta Kaewkroek, Chatchai Wattanapiromsakul, Palangpon Kongsaeree, Supinya Tewtrakul Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata. Natural Product Communications. Vol.8, No.9 (2013), 1205-1208. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31112
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Title
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata
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Abstract
The ethanol extract of the rhizomes of Kaempferia marginata showed a potent inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) release in RAW264.7 cells. Moreover, the partition with various organic solvents also inhibited NO production. One new pimarane-type diterpene, 1α- acetoxysandaracopimaradien-2α-ol (5), along with four known diterpenes (1-4), were isolated from the n-hexane and chloroform layers, respectively. Among these metabolites, compounds 1 and 4 were isolated for the first time from K. marginata. Compounds 1-5 showed significant inhibitory effects on NO production, with IC50 values ranging from 38.6 to 51.9 μM. Furthermore, compound 2 also exhibited significant activity against TNF-α release (1C50 = 48.3 μM). These findings may support the use of K. marginata by traditional doctors for treatment of inflammatory-related diseases.