Publication: Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal
Issued Date
2013-03-01
Resource Type
ISSN
16784391
14138670
14138670
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2-s2.0-84876712887
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Mahidol University
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SCOPUS
Bibliographic Citation
Brazilian Journal of Infectious Diseases. Vol.17, No.2 (2013), 256-259
Suggested Citation
Pankaj Baral, Sanjiv Neupane, Basudha Shrestha, Kashi Ram Ghimire, Bishnu Prasad Marasini, Binod Lekhak Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal. Brazilian Journal of Infectious Diseases. Vol.17, No.2 (2013), 256-259. doi:10.1016/j.bjid.2012.09.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32457
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Title
Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal
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Abstract
Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p<. 0.001) and being inpatients (OR, 4.587; CI, 2.132-9.9; p<. 0.001) were associated with ABL positivity. Regular antimicrobial resistance surveillance for ABL-producing Enterobacteriaceae is warranted for proper antimicrobial treatment strategy and policy making due to ABL-positive infections. © 2013 Elsevier Editora Ltda.