Publication: Serum bactericidal and inhibitory titres in the management of melioidosis
Issued Date
2000-02-02
Resource Type
ISSN
03057453
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2-s2.0-0033957616
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Antimicrobial Chemotherapy. Vol.45, No.1 (2000), 123-127
Suggested Citation
Andrew J.H. Simpson, David A.B. Dance, Vanaporn Wuthiekanun, Nicholas J. White Serum bactericidal and inhibitory titres in the management of melioidosis. Journal of Antimicrobial Chemotherapy. Vol.45, No.1 (2000), 123-127. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26281
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Title
Serum bactericidal and inhibitory titres in the management of melioidosis
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Abstract
A retrospective evaluation of the relationship between serum bactericidal and inhibitory titres and treatment outcome in 195 adult Thai patients with severe melioidosis was conducted. Drug regimens included ceftazidime (52% of patients), co-amoxiclav (24%), imipenem (11%) or the conventional four-drug combination (11%). Pre- and 1 h post-dose serum samples were collected after 48-72 h of therapy, and serum inhibitory and bactericidal titrations determined. Median post-dose titres were: bactericidal 1:8 (range 0-1:128) and inhibitory 1:16 (range 0-1:128). Overall mortality was 26% and outcome was not influenced by either inhibitory or bactericidal titres. Pre-dose titres correlated with renal function; renal function was the most important predictor of mortality. Determination of serum inhibitory or bactericidal titres is unhelpful in the management of severe melioidosis.