Publication: Cardiac involvement in beta-thalassemia/hemoglobin E disease: clinical and hemodynamic findings.
Issued Date
1990-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0025441923
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.21, No.2 (1990), 269-273
Suggested Citation
P. Jootar, S. Fucharoen Cardiac involvement in beta-thalassemia/hemoglobin E disease: clinical and hemodynamic findings.. The Southeast Asian journal of tropical medicine and public health. Vol.21, No.2 (1990), 269-273. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16041
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Title
Cardiac involvement in beta-thalassemia/hemoglobin E disease: clinical and hemodynamic findings.
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Abstract
Clinical and hemodynamic studies were conducted in 6 women and 2 men with beta-thalassemia/hemoglobin E disease. All except one had splenectomy. The patients were hospitalized in the state of congestive heart failure. The systemic blood pressure was low or normal. The electrocardiograms revealed normal sinus rhythm in all, right axis deviation in some, right atrial enlargement in the majority and repolarization abnormalities in some. The echocardiograms were sensitive to detect the right heart abnormalities and pericardial effusion. Cardiac catheterization disclosed moderate to marked hypoxemia. All patients except one had pulmonary hypertension. Some had left ventricular dysfunction. From this study. It is concluded that right heart involvement secondary to diffuse pulmonary thromboembolic disease is a major complication of beta-thalassemia/hemoglobin E disease.