Publication: Duration of shedding of respiratory syncytial virus in a community study of Kenyan children
Accepted Date
2010-01-22
Issued Date
2010-01-22
Copyright Date
2010
Resource Type
Language
eng
ISSN
1471-2334 (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Okiro EA, White LJ, Ngama M, Cane PA, Medley GF, Nokes DJ. Duration of shedding of respiratory syncytial virus in a community study of Kenyan children. BMC Infect Dis. 2010 Jan 22;10:15.
Suggested Citation
Okiro, Emelda A., White, Lisa J., Ngama, Mwanajuma, Cane, Patricia A., Medley, Graham F., Nokes, D James Duration of shedding of respiratory syncytial virus in a community study of Kenyan children. Okiro EA, White LJ, Ngama M, Cane PA, Medley GF, Nokes DJ. Duration of shedding of respiratory syncytial virus in a community study of Kenyan children. BMC Infect Dis. 2010 Jan 22;10:15.. doi:10.1186/1471-2334-10-15 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/739
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Title
Duration of shedding of respiratory syncytial virus in a community study of Kenyan children
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Abstract
BACKGROUND: Our understanding of the transmission dynamics of respiratory
syncytial virus (RSV) infection will be better informed with improved data on the
patterns of shedding in cases not limited only to hospital admissions.
METHODS: In a household study, children testing RSV positive by direct
immunofluorescent antibody test (DFA) were enrolled. Nasal washings were
scheduled right away, then every three days until day 14, every 7 days until day
28 and every 2 weeks until a maximum of 16 weeks, or until the first DFA negative
RSV specimen. The relationship between host factors, illness severity and viral
shedding was investigated using Cox regression methods.
RESULTS: From 151 families a total of 193 children were enrolled with a median
age of 21 months (range 1-164 months), 10% infants and 46% male. The rate of
recovery from infection was 0.22/person/day (95% CI 0.19-0.25) equivalent to a
mean duration of shedding of 4.5 days (95%CI 4.0-5.3), with a median duration of
shedding of 4 days (IQR 2-6, range 1-14). Children with a history of RSV
infection had a 40% increased rate of recovery i.e. shorter duration of viral
shedding (hazard ratio 1.4, 95% CI 1.01-1.86). The rate of cessation of shedding
did not differ significantly between males and females, by severity of infection
or by age.
CONCLUSION: We provide evidence of a relationship between the duration of
shedding and history of infection, which may have a bearing on the relative role
of primary versus re-infections in RSV transmission in the community.