Publication: A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and Iodine status of primary school children in north east Thailand: a randomized controlled trial of efficacy
2
Issued Date
2006
Resource Type
Language
eng
ISSN
0022-3166 (print)
1541-6100 (electronic)
1541-6100 (electronic)
Rights Holder(s)
American Society for Nutrition
Bibliographic Citation
The Journal of Nutrition. Vol. 136, No. 6 (2006), 1617-1623
Suggested Citation
Pattanee Winichagoon, McKenzie, Joanne E., Visith Chavasit, Tippawan Pongcharoen, Sueppong Gowachirapant, Atitada Boonpraderm, Mari S. Manger, Bailey, Karl B., Emorn Wasantwisut, Rosalind S. Gibson A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and Iodine status of primary school children in north east Thailand: a randomized controlled trial of efficacy. The Journal of Nutrition. Vol. 136, No. 6 (2006), 1617-1623. doi:https://doi.org/10.1093/jn/136.6.1617 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30074
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and Iodine status of primary school children in north east Thailand: a randomized controlled trial of efficacy
Abstract
Anemia and co-existing deficiencies of zinc, iron, iodine, and vitamin A occur among children in many
developing countries including NE Thailand, probably contributing to impairments in growth, immune competence,
and cognition. Sustainable strategies are urgently required to combat these deficiencies. We assessed the efficacy of
a micronutrient-fortified seasoning powder served with a school lunch on reducing anemia and improving the
micronutrient status of rural NE Thai children. Children (n ¼ 569) aged 5.5–13.4y from 10 schools were randomly
assigned to receive a seasoning powder either unfortified or fortified with zinc (5 mg), iron (5 mg), vitamin A (270 mg),
and iodine (50 mg) (per serving) and incorporated into a school lunch prepared centrally and delivered 5 d/wk for 31
wk. Teachers monitored school lunch consumption. Baseline and final micronutrient status, hemoglobinopathies, and
infection or inflammation were assessed from blood and urine samples. For the primary outcome, anemia (based on
hemoglobin), no intervention effect was apparent (odds ratio: 1.02 95% CI: 0.69, 1.51) after adjustment for design
strata. The odds of zinc (based on serum zinc) and urinary iodine deficiency in the fortified group were 0.63 (0.42,
0.94) and 0.52 (0.38, 0.71) times those in the unfortified group, respectively. Fortification had no effect on serum
retinol (0.61: 0.25,1.51), ferritin (1.12: 0.43, 2.96), or mean red cell volume (1.16: 0.82, 1.64). Therefore, a
micronutrient-fortified seasoning powder is a promising vehicle for improving zinc, iodine, and hemoglobin status, and
its potential for incorporation into lunch programs in day care centers and schools in NE Thailand warrants