Publication: Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE
Issued Date
2021-05-01
Resource Type
ISSN
18792472
00493848
00493848
Other identifier(s)
2-s2.0-85101654263
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Mahidol University
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SCOPUS
Bibliographic Citation
Thrombosis Research. Vol.201, (2021), 63-72
Suggested Citation
Pantep Angchaisuksiri, Shinya Goto, Alfredo E. Farjat, Henrik Fryk, Soo Mee Bang, Chern En Chiang, Zhi Cheng Jing, Katsuhiro Kondo, Jameela Sathar, Eric Tse, Sithakom Phusanti, Gloria Kayani, Jeffrey I. Weitz, Walter Ageno, Samuel Z. Goldhaber, Ajay K. Kakkar Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE. Thrombosis Research. Vol.201, (2021), 63-72. doi:10.1016/j.thromres.2021.02.024 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78265
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Title
Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE
Other Contributor(s)
Ramathibodi Hospital
Thrombosis & Atherosclerosis Research Institute
Seoul National University Bundang Hospital
Tokai University School of Medicine
University College London
Brigham and Women's Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thrombosis Research Institute
Veterans General Hospital-Taipei
Peking Union Medical College Hospital
The University of Hong Kong
Università degli Studi dell'Insubria
Kokura Kinen Hospital
Hospital Ampang
Thrombosis & Atherosclerosis Research Institute
Seoul National University Bundang Hospital
Tokai University School of Medicine
University College London
Brigham and Women's Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thrombosis Research Institute
Veterans General Hospital-Taipei
Peking Union Medical College Hospital
The University of Hong Kong
Università degli Studi dell'Insubria
Kokura Kinen Hospital
Hospital Ampang
Abstract
Background: Although epidemiological studies report a lower risk of venous thromboembolism (VTE) than in the Western world, VTE rates in Asia may be underestimated. Furthermore, it is uncertain whether VTE outcomes differ in Asia and the rest of the world (ROW). Methods: GARFIELD-VTE is a global, prospective, non-interventional study of real-world treatment practices. In this study, we compared baseline characteristics, treatment patterns, and 12-month outcomes in Asia and ROW. Results: Of the 10,684 enrolled patients, 1822 (17.1%) were Asian (China n = 420, Hong Kong n = 98, Japan n = 148, Malaysia n = 244, South Korea n = 343, Taiwan n = 232, Thailand n = 337). Compared with ROW patients, those from Asia were more often female (57.4% vs. 48.0%), non-smokers (74.0% vs. 58.9%) and had a lower BMI (24.8 kg/m2 vs. 29.1 kg/m2). Asian patients were more likely to be managed in the hospital (86.9% vs. 70.4%) and to have active cancer (19.8% vs. 8.1%) or a history of cancer (19.1% vs. 12.0%). Asian patients received no anticoagulation more frequently than ROW patients (6.5% vs. 2.1%). Over 12-months follow-up, the rate of all-cause mortality (per 100 person-years [95% confidence interval]) was higher in Asians (15.2 [13.4–17.3] vs. 5.9 [5.4–6.5]). Adjusted hazard ratios indicated a higher risk of all-cause mortality in Asian patients than the ROW (1.32 [1.08–1.62]). The frequencies of major bleeding and recurrent VTE were similar. Conclusion: Asian patients have different risk profiles, treatment patterns and a higher risk of mortality compared with the ROW.