Publication: Influence of hemoglobin E trait on the antimalarial effect of artemisinin derivatives
Issued Date
2000-05-22
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0034022749
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.181, No.4 (2000), 1513-1516
Suggested Citation
Robert Hutagalung, Polrat Wilairatana, Sornchai Looareesuwan, Gary M. Brittenham, Victor R. Gordeuk Influence of hemoglobin E trait on the antimalarial effect of artemisinin derivatives. Journal of Infectious Diseases. Vol.181, No.4 (2000), 1513-1516. doi:10.1086/315373 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26242
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Influence of hemoglobin E trait on the antimalarial effect of artemisinin derivatives
Abstract
To determine whether hemoglobin E trait influences the antimalarial effect of artemisinin derivatives, we retrospectively compared 32 case patients with hemoglobin E trait to 32 control patients who did not have hemoglobin E, β-thalassemia, glucose-6-phosphate dehydrogenase deficiency, or α-thalassemia trait on the basis of a mean corpuscular volume ≥78 femtoliters. All patients were admitted to the Hospital for Tropical Diseases in Bangkok, Thailand, with acute falciparum malaria. Control patients were matched to case patients with hemoglobin E trait by treatment with artemisinin derivatives versus other antimalarial drugs, by ethnic group, and by parasite count. Among 38 patients treated with artemisinin derivatives, the presence of hemoglobin E trait was associated with significantly faster parasite clearance (2.9-fold; 95% confidence interval [CI], 1.4-6.3; P = .006). Among 26 patients treated only with other antimalarial drugs, hemoglobin E trait did not significantly enhance parasite clearance (hazards ratio, 1.1; 95% CI, 0.5-2.5; P = .8). Hemoglobin E trait may potentiate the antimalarial effect of artemisinin derivatives.